144501-27-9

Basic information

• Product Name: (3S,5R,6E)-7-[4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid
• Synonyms: GR 92549
• CAS NO: 144501-27-9
• Molecular Formula: C₂₅H₂₆F₂N₂O₄
• Molecular Weight: 456.4817
• Mol File: 144501-27-9.mol

Chemical Properties

• Boiling Point: 699.3°C at 760 mmHg
• Flash Point: 376.7°C
• Density: 1.27g/cm³
• Vapor Pressure: 1.59E-20mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: (3S,5R,6E)-7-[4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5R,6E)-7-[4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid(144501-27-9)
• EPA Substance Registry System: (3S,5R,6E)-7-[4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid(144501-27-9)

Safety Data

• Hazardous Substances Data: 144501-27-9(Hazardous Substances Data)

Upstream product

• 152770-16-6 (E,3S,5R)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 129360-72-1 (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenal 
• 152770-17-7 (E,3R,5R)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 152770-18-8 (E,3S,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 129360-77-6 (E,3S)-5-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3-hydroxy-4-pentenoic acid (S)-1,1,2-triphenylethyl ester 
• 129360-78-7 (E,3S)-5-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3-hydroxy-4-pentenoic acid, methyl ester 
• 152770-14-4 (E,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 129360-98-1 (E,3R,5S)-7-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-3,5-dihydroxy-6-heptenoic acid 1,1-dimethyleth-1-yl ester 
• 144-55-8 sodium hydrogencarbonate 
• 129359-41-7 (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenoic acid, methyl ester 
• 129360-69-6 (E)-3-<4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazol-1-yl>-2-propenol 
• 129360-64-1 4,5-bis(4-fluorophenyl)-2-(1-methylethyl)-1H-imidazole 

Relevant articles and documents

Inhibitors of cholesterol biosynthesis. 1. 3,5-dihydroxy-7-(N-imidazolyl)- 6-heptenoates and -heptanoates, a novel series of HMG-CoA reductase inhibitors

3,5-Dihydroxy-7-(N-imidazolyl)heptanoates 4 and the corresponding heptenoates 5 were synthesized as novel classes of potent HMG-CoA reductase (HMGR) inhibitors in which members of the latter series possess enzyme inhibitory activity greater than that of l

Imidazole derivatives and their use as hypercholesterolemia and hyperlipoproteinemia agents

Compounds of formula STR1 wherein R1 or R2 represents a C1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl or pyridyl ring or N-oxide thereof optionally substituted by o