144619-46-5 Usage
Uses
Used in Medicinal Chemistry:
(3R)-3-chloro-6-fluoro-3-phenylquinoline-2,4(1H,3H)-dione is used as a compound with potential pharmacological and biological activities for the development of new drugs and therapies. Its unique structure and properties may contribute to the discovery of novel treatments for various diseases and conditions.
Used in Drug Development:
(3R)-3-chloro-6-fluoro-3-phenylquinoline-2,4(1H,3H)-dione is used as a starting point for the design and synthesis of new drug candidates. Its potential biological activities and interactions with biological targets make it a valuable component in the development of innovative pharmaceuticals.
Further research and study are needed to fully understand the properties and potential uses of (3R)-3-chloro-6-fluoro-3-phenylquinoline-2,4(1H,3H)-dione, as its applications in medicinal chemistry and drug development are still being explored.
Check Digit Verification of cas no
The CAS Registry Mumber 144619-46-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,6,1 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 144619-46:
(8*1)+(7*4)+(6*4)+(5*6)+(4*1)+(3*9)+(2*4)+(1*6)=135
135 % 10 = 5
So 144619-46-5 is a valid CAS Registry Number.
144619-46-5Relevant articles and documents
Halogenation Reactions in Position 3 of Quinoline-2,4-dione Systems by Electrophilic Substitution and Halogen Exchange
Stadlbauer, Wolfgang,Laschober, Rita,Lutschounig, Herbert,Schindler, Gerda,Kappe, Thomas
, p. 617 - 636 (2007/10/02)
3-Substituted 4-hydroxy-2(1H)-quinolones 3, 5, 7 are halogenated with bromine or sulfuryl chloride to yield the quinolinediones 9 or 10.Reactions of 3, 5, 7 with chloroform gives the dichloromethyl quinolinediones 11.Halogen exchange leads from the chloro quinolinediones 10 to fluoro quinolinedones 12 and to azido quinolinediones 13.Similarly the dichloro quinolinediones 10an reacts to the difluoro quinolinedione 14, which is reduced to the 3-fluoro-4-hydroxyquinolone 16 and reacts again with sulfuryl chloride to give the mixed 3-chloro-3-fluoroquinolinedione 15.Keywords.Fluorination; 4-Hydroxy-2(1H)-quinolones, 3-alkyl/3-aryl/3-fluoro; 1-Hydroxy-benzoquinolizine-3-ones, 2-alkyl/3-aryl; Quinoline-2,4(1H,3H)-diones, 3-azido-3-alkyl/3-aryl, 3-bromo-3-alkyl/3-aryl, 3-chloro-3-alkyl/3-aryl, 3-fluoro-3-alkyl/3-aryl, 3-dichloromethyl-3-alkyl/3-aryl, 3-chloro-3-fluoro.
