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3-(3-(4-chloro-5-fluoropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazol-5-yl)isoxazole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1446358-48-0

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1446358-48-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1446358-48-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,4,6,3,5 and 8 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1446358-48:
(9*1)+(8*4)+(7*4)+(6*6)+(5*3)+(4*5)+(3*8)+(2*4)+(1*8)=180
180 % 10 = 0
So 1446358-48-0 is a valid CAS Registry Number.

1446358-48-0Relevant articles and documents

Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator

Rennie, Glen R.,Barden, Timothy C.,Bernier, Sylvie G.,Carvalho, Andrew,Deming, Renee,Germano, Peter,Hudson, Colleen,Im, G-Yoon J.,Iyengar, Rajesh R.,Jia, Lei,Jung, Joon,Kim, Elise,Lee, Thomas W.-H.,Mermerian, Ara,Moore, Joel,Nakai, Takashi,Perl, Nicholas R.,Tobin, Jenny,Zimmer, Daniel P.,Renhowe, Paul A.

, (2021/03/22)

Soluble guanylate cyclase (sGC) is a clinically validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction pathw

NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS

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, (2019/08/20)

The present disclosure relates to novel processes for the preparation of compounds of Formula I. Some of these compounds are useful as stimulators of soluble guanylate cyclase (sGC). Others are useful intermediates towards the preparation of said stimulat

SOLID DISPERSIONS COMPRISING A SGC STIMULATOR

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, (2017/06/27)

The present invention relates to solid dispersions of amorphous 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4-yl)amino)methyl)propan-2-ol (Compound I) or a pharmaceutically acceptable salt thereof. It also relates to pharmaceutical compositions and pharmaceutical oral dosage unit forms comprising them, and their uses thereof.

PYRAZOLE DERIVATIVES AS SGC STIMULATORS

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, (2016/04/09)

There are described imidazole and pyrazole derivatives which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

Nakai, Takashi,Perl, Nicholas R.,Barden, Timothy C.,Carvalho, Andrew,Fretzen, Angelika,Germano, Peter,Im, G-Yoon J.,Jin, Hong,Kim, Charles,Lee, Thomas W.-H.,Long, Kimberly,Moore, Joel,Rohde, Jason M.,Sarno, Renee,Segal, Chrissie,Solberg, Erik O.,Tobin, Jenny,Zimmer, Daniel P.,Currie, Mark G.

supporting information, p. 465 - 469 (2016/06/01)

In recent years, soluble guanylate cyclase (sGC, EC 4.6.1.2) has emerged as an attractive therapeutic target for treating cardiovascular diseases and diseases associated with fibrosis and end-organ failure. Herein, we describe our design and synthesis of

SGC STIMULATORS

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Paragraph 00295, (2016/04/20)

The present patent application discloses at least the compounds according to Formula I' shown below, or pharmaceutically acceptable salts thereof, Formula (I) wherein ring D, ring A, ring E, JB, n, JD, J, X, Z, Z1, RC

sGC STIMULATORS

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Paragraph 00314, (2016/04/09)

The present patent application discloses at least the compounds according to Formula (Ia) and Formula (Ib) shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, JB, n, J, RC1, RC2, Z1, Z2, W, X, Y1, Y2, JF and R9 are as defined herein.

SGC STIMULATORS

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Paragraph 00274, (2014/09/29)

Compounds of Formulae (I') and (I) are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS

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Page/Page column 105, (2013/07/19)

2-Benzyl, 3 - (pyrimidin- 2 -YL) substituted pyrazoles are described. They are useful as stimulators of sGC, particularly NO - independent, heme - dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.

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