1354044-23-7

Upstream product

• 88511-37-9 1-(isoxazol-3-yl)ethan-1-one 
• 1354044-05-5 1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazole-3-carboximidamide hydrochloride 
• 1446353-66-7 C₁₄H₉FN₄O 
• 1446353-53-2 C₁₄H₁₀FN₃O₃ 

Downstream Products

• 1354041-84-1 C₁₇H₁₃FN₆O₂ 
• 1354041-90-9 2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4-ol 
• 1354043-85-8 C₁₈H₁₄FN₅O₂ 
• 1446358-76-4 3-(5-fluoro-6-oxo-1,6-dihydropyrimidin-2-yl)-1-(2-fluorobenzyl)-1H-pyrazole-5-carbonitrile 
• 1446358-78-6 C₁₇H₁₃FN₆O₂ 
• 1446358-79-7 C₂₂H₁₉FN₆O₃ 
• 1446358-80-0 C₁₇H₁₀BrClFN₅O 
• 1446359-92-7 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-81-1 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-82-2 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-83-3 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-84-4 4-chloro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidine-5-sulfonyl chloride 
• 1446358-85-5 C₂₄H₁₇BrFN₅O₂ 
• 1446358-86-6 C₂₅H₁₉BrFN₅O₃ 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVES AS SGC STIMULATORS

There are described imidazole and pyrazole derivatives which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

sGC STIMULATORS

The present patent application discloses at least the compounds according to Formula (Ia) and Formula (Ib) shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, JB, n, J, RC1, RC2, Z1, Z2, W, X, Y1, Y2, JF and R9 are as defined herein.

Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans

In recent years, soluble guanylate cyclase (sGC, EC 4.6.1.2) has emerged as an attractive therapeutic target for treating cardiovascular diseases and diseases associated with fibrosis and end-organ failure. Herein, we describe our design and synthesis of

2 - BENZYL, 3 - (PYRIMIDIN- 2 -YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS

2-Benzyl, 3 - (pyrimidin- 2 -YL) substituted pyrazoles are described. They are useful as stimulators of sGC, particularly NO - independent, heme - dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.