Inhibitors of the advanced glycosylation of proteins and methods of use therefor
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of an early glycosylation product of such target proteins resulting from their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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(2008/06/13)
Inhibitors of the advanced glycosylation of proteins and methods of use therefor
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylatin. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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(2008/06/13)
Synthesis of carbon-13 labelled uracil, 6,7-dimethyllumazine, and lumichrome, via a common intermediate: cyanoacetylurea
Compounds of the formula EQU1 where R is CH3 OCH2 -- or CH3 O(CH2)3 -- and R1 is alkyl of 1 or 2 carbon atoms are effective plant disease control agents.
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(2008/06/13)
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