144881-51-6

Basic information

• Product Name: 1-[4-(propan-2-yloxy)phenyl]piperazine
• CAS NO: 144881-51-6
• Molecular Formula: C₁₃H₂₀N₂O
• Molecular Weight: 220.3107
• Mol File: 144881-51-6.mol

Chemical Properties

• Boiling Point: 363.3°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.024g/cm³
• Vapor Pressure: 1.82E-05mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 1-[4-(propan-2-yloxy)phenyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(propan-2-yloxy)phenyl]piperazine(144881-51-6)
• EPA Substance Registry System: 1-[4-(propan-2-yloxy)phenyl]piperazine(144881-51-6)

Safety Data

• Hazardous Substances Data: 144881-51-6(Hazardous Substances Data)

Usage

Synonyms

PAPP

Class

Piperazine derivative

Appearance

White solid at room temperature

Solubility

Soluble in organic solvents such as dichloromethane and methanol

Pharmaceutical use

Often used as a pharmaceutical drug or intermediate in the synthesis of pharmaceuticals

Therapeutic applications

Studied for potential use as an antipsychotic agent

Cognitive dysfunction

Investigated for potential role in treating cognitive dysfunction

Neurotransmitter interactions

Interactions with various neurotransmitter systems in the brain have been studied

Research and development

Holds promise for further research and development in the field of medication development

Upstream product

• 7664-66-6 4-(isopropoxy)aniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 222637-85-6 4-isopropoxybenzenamine hydrochloride 

Downstream Products

• 1364525-21-2 C₁₅H₁₉F₃N₂O₂ 
• 1609122-95-3 N-(5-(4-benzylpiperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609122-96-4 N-(5-(4-(4-nitrobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609122-97-5 N-(5-(4-(3-nitrobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609122-98-6 N-(5-(4-(2-nitrobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609122-99-7 N-(5-(4-(3,5-dinitrobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-00-3 N-(5-(4-(4-chlorobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-01-4 N-(5-(4-(4-cyanobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-02-5 N-(5-(4-(4-fluorobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-03-6 N-(5-(4-(4-bromobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-04-7 methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazin-1-yl)methyl)benzoate 
• 1609123-06-9 methyl 4-((4-(4-isopropoxy-3-(pyrazine-2-carboxamido)phenyl)piperazine-1-yl)methyl)benzenesulfonate 
• 1609123-08-1 N-(5-(4-(4-methylbenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 
• 1609123-09-2 N-(5-(4-(4-aminobenzyl)piperazin-1-yl)-2-isopropoxyphenyl)pyrazine-2-carboxamide 

Relevant articles and documents

Design, syntheses, and characterization of piperazine based chemokine receptor CCR5 antagonists as anti prostate cancer agents

Chemokine receptor CCR5 plays an important role in the pro-inflammatory environment that aids in the proliferation of prostate cancer cells. Previously, a series of CCR5 antagonists containing a piperidine ring core skeleton were designed based upon the proposed CCR5 antagonist pharmacophore from molecular modeling studies. The developed CCR5 antagonists were able to antagonize CCR5 at a micromolar level and inhibit the proliferation of metastatic prostate cancer cell lines. In order to further explore the structure-activity-relationship of the pharmacophore identified, the molecular scaffold was expanded to contain a piperazine ring as the core. A number of compounds that were synthesized showed promising anti prostate cancer activity and reasonable cytotoxicity profiles based on the biological characterization.

Heterocyclic compounds for the treatment of CNS and cardiovascular disorders

Novel aromatic bicyclic amines of formula (I) STR1 are useful in treating central nervous system disorders and cardiac arrhythmias and cardiac fibrillation.