1450723-65-5

Upstream product

• 623-00-7 4-bromobenzenecarbonitrile 
• 1233509-85-7 sodium 3,5-difluorobenzenesulfinate 
• 99389-26-1 3,5-difluorobenzenethiol 
• 1450723-64-4 4-(3,5-difluorophenylsulfanyl)benzonitrile 
• 1194-02-1 4-fluorobenzonitrile 

Downstream Products

• 1450723-26-8 1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxylic acid 4-(3,5-difluorobenzenesulfonyl)benzylamide 
• 1448536-61-5 (4-((3,5-difluorophenyl)sulfonyl)phenyl)methanamine 
• 1450724-09-0 C₂₀H₁₄F₂N₂O₆S 
• 1454284-64-0 3-aminoimidazo[1,2-a]pyridine-6-carboxylic acid 4-(3,5-difluorobenzenesulfonyl)benzylamide 
• 1454285-16-5 N-([4-[(3,5-difluorobenzene)sulfonyl]phenyl]methyl)pyrazolo[1,5-b]pyridazine-5-carboxamide 
• 1454285-12-1 6-amino-N-[[4-(3,5-difluorophenyl)sulfonylphenyl]methyl]-1H-pyrrolo[3.2-c]pyridine-2-carboxamide 
• 1454285-45-0 6-amino-4-chloro-N-([4-[(3,5-difluorobenzene)sulfonyl]phenyl]methyl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide 
• 1454285-44-9 6-[bis[(4-methoxyphenyl)methyl]amino]-4-chloro-N-([4-[(3,5-difluorobenzene)sulfonyl]phenyl]methyl)-1H-pyrrolo[3.2-c]pyridine-2-carboxamide 
• 1454284-67-3 imidazo[1.2-b]pyridazine-6-carboxylic acid 4-(3,5-difluorobenzenesulfonyl)benzylamide 
• 1454285-27-8 3-tert-butylamino imidazo[1,2-a]pyridine-6-carboxylic acid 4-(3,5-difluorobenzenesulfonyl)benzylamide 

Relevant academic research and scientific papers

Hantzsch Ester as a Visible-Light Photoredox Catalyst for Transition-Metal-Free Coupling of Arylhalides and Arylsulfinates

Diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (HEH) has been utilized as a visible-light photoredox catalyst for the cross coupling of arylhalides and arylsulfinates without transition metal, sacrificial agent, and mediator. This method is compatible with various functional groups and provides diaryl sulfones in good to high yields. Mechanistic studies indicate that this reaction undergoes the stepwise light irradiation of HE?, single electron transfer (SET) in donor–acceptor complex (DAC) from *HE? to arylhalide, trapping of aryl radical with sulfinate, and SET oxidation of sulfone radical anion by HE. to sulfone by the DAC method.

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determined using a high-throughput solubility assessment, relative to previously disclosed urea and amide-containing NAMPT inhibitors. An optimized 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived compound exhibited potent anti-NAMPT activity (18; BC NAMPT IC50 = 11 nM; PC-3 antiproliferative IC50 = 36 nM), satisfactory mouse PK properties, and was efficacious in a PC-3 mouse xenograft model. The crystal structure of another optimized compound (29; NAMPT IC50 = 10 nM; A2780 antiproliferative IC50 = 7 nM) in complex with the NAMPT protein was also determined.

AMIDO-BENZYL SULFONE AND SULFONAMIDE DERIVATIVES

Disclosed are certain amido-benzyl sulfone and sulfonamide compounds, pharmaceutical compositions comprising such compounds, land methods of treatment using such compounds.