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3-Fluoro-4-methylbenzyl bromide, with the molecular formula C8H8BrF, is a colorless liquid chemical compound characterized by a molecular weight of 207.05 g/mol. It serves as a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals, playing a crucial role in the development of various organic compounds.

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  • 145075-44-1 Structure
  • Basic information

    1. Product Name: 3-FLUORO-4-METHYLBENZYL BROMIDE
    2. Synonyms: 3-FLUORO-4-METHYLBENZYL BROMIDE;4-(broMoMethyl)-2-fluoro-1-Methylbenzene;4-(Bromomethyl)-2-fluoro-1-methylbenzene, alpha-Bromo-3-fluoro-p-xylene
    3. CAS NO:145075-44-1
    4. Molecular Formula: C8H8BrF
    5. Molecular Weight: 203.05
    6. EINECS: N/A
    7. Product Categories: Benzene series
    8. Mol File: 145075-44-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 77°C/3mm
    3. Flash Point: 77°C/3mm
    4. Appearance: UN 1760
    5. Density: 1.456 g/cm3
    6. Vapor Pressure: 0.292mmHg at 25°C
    7. Refractive Index: 1.5460
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. Sensitive: Lachrymatory
    11. CAS DataBase Reference: 3-FLUORO-4-METHYLBENZYL BROMIDE(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-FLUORO-4-METHYLBENZYL BROMIDE(145075-44-1)
    13. EPA Substance Registry System: 3-FLUORO-4-METHYLBENZYL BROMIDE(145075-44-1)
  • Safety Data

    1. Hazard Codes: C
    2. Statements: 34-36/37/38
    3. Safety Statements: 26-36/37/39
    4. RIDADR: 1760
    5. WGK Germany:
    6. RTECS:
    7. HazardClass: 8
    8. PackingGroup: III
    9. Hazardous Substances Data: 145075-44-1(Hazardous Substances Data)

145075-44-1 Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-4-methylbenzyl bromide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties. Its unique structure allows for the creation of molecules with potential medicinal applications.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Fluoro-4-methylbenzyl bromide is utilized as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness in controlling pests and weeds, thereby improving crop yields and quality.
Used in Organic Synthesis:
3-Fluoro-4-methylbenzyl bromide is employed as a reagent in organic synthesis, where it can be used to form new chemical bonds and create a variety of organic compounds. Its reactivity and stability make it a valuable component in the synthesis of complex organic molecules.
Used in Specialty Chemicals Production:
3-FLUORO-4-METHYLBENZYL BROMIDE is also used in the production of specialty chemicals, which are high-value chemicals used in specific applications such as fragrances, dyes, and coatings. The unique properties of 3-Fluoro-4-methylbenzyl bromide contribute to the development of these specialty chemicals, enhancing their performance and functionality.
Safety Precautions:

Check Digit Verification of cas no

The CAS Registry Mumber 145075-44-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,0,7 and 5 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 145075-44:
(8*1)+(7*4)+(6*5)+(5*0)+(4*7)+(3*5)+(2*4)+(1*4)=121
121 % 10 = 1
So 145075-44-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H8BrF/c1-6-2-3-7(5-9)4-8(6)10/h2-4H,5H2,1H3

145075-44-1 Well-known Company Product Price

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  • Alfa Aesar

  • (H26349)  3-Fluoro-4-methylbenzyl bromide, 97%   

  • 145075-44-1

  • 1g

  • 1636.0CNY

  • Detail
  • Alfa Aesar

  • (H26349)  3-Fluoro-4-methylbenzyl bromide, 97%   

  • 145075-44-1

  • 5g

  • 5032.0CNY

  • Detail

145075-44-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(bromomethyl)-2-fluoro-1-methylbenzene

1.2 Other means of identification

Product number -
Other names 4-(Bromomethyl)-2-fluoro-1-methylbenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:145075-44-1 SDS

145075-44-1Relevant articles and documents

PYRROLE AND PYRAZOLE COMPOUNDS AND METHODS OF USE THEREOF

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, (2020/06/19)

The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation. The present disclosure provides compounds having hormone receptor antagonis

Synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters from arylmethyl azides via a domino process

Tummatorn, Jumreang,Thongsornkleeb, Charnsak,Ruchirawat, Somsak,Gettongsong, Tanita

supporting information, p. 1463 - 1467 (2013/05/08)

A convenient synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters via a domino process is described. The synthesis employs arylmethyl azides as the precursor which undergoes an acid-promoted rearrangement to give an N-aryl iminium ion. Following the addition with ethyl 3-ethoxyacrylate, intramolecular electrophilic aromatic substitution, elimination and subsequent oxidation, the quinoline products were obtained in moderate to excellent yields.

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