145231-35-2 Usage
Uses
1. Used in Pharmaceutical Industry:
N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA is used as a potent histamine H3 antagonist for its ability to block histamine H3 receptors, which play a role in various physiological processes, including the regulation of wakefulness, appetite, and cognitive functions.
2. Used in Research Applications:
In the field of research, N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA serves as a valuable tool for studying the role of histamine H3 receptors in various biological processes and for the development of new drugs targeting these receptors.
3. Used in Drug Development:
N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA and its analogues can be used in the development of new drugs for the treatment of various conditions, such as sleep disorders, cognitive impairment, and obesity, by modulating histamine H3 receptor activity.
4. Used in Chemical Synthesis:
N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA can also be used as a starting material or intermediate in the synthesis of other related compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 145231-35-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,2,3 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 145231-35:
(8*1)+(7*4)+(6*5)+(5*2)+(4*3)+(3*1)+(2*3)+(1*5)=102
102 % 10 = 2
So 145231-35-2 is a valid CAS Registry Number.
145231-35-2Relevant articles and documents
Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H3-receptor
Van der Goot,Schepers,Sterk,Timmerman
, p. 511 - 517 (2007/10/02)
The synthesis and H3-activity of a series of isothiourea analogues of histamine have been described. It has been shown that S-[2-(4(5)-imidazolyl)ethylisothiourea (VUF 8325) is a potent H3-agonist measured as the electrically evoked contraction of the guinea-pig ileum. Upon methylation of the imidazole system or the isothiourea moiety a decrease in affinity was observed leading to either weak agonists or weak antagonists. Introduction of N-(phenylalkyl) substituents at the isothiourea part gives rise to highly potent H3-antagonists. Particularly the 4-chlorobenzyl group appeared to be favourable in the series described resulting in a histamine H3-antagonist with a pA2-value of 9.9.
