DNA Strand Scissions by Hydroxamic Acids-Copper(II) Ion under Aerobic Conditions
Carbazolyloxyacetohydroxamic acid (1), 9.9'-decamethylene-bis-carbazolyloxyacetohydroxamic acid (2), benzohydroxamic acid (3) and acetohydroxamic acid (4) without reducing agent under aerobic conditions induced Col E1 DNA strand scissions with increasing of the activities in the order 4 > 3 > 2 > 1.Inhibition experiments indicated that hydrogen peroxide and superoxide participated in the reactions, but hydroxyl radical or singlet oxygen did not.