- Recyclable copper catalyzed nitrogenation of biphenyl halides: A direct approach to carbazoles
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A novel A21-CuI catalyzed direct nitrogenation of biphenyl halides for the direct synthesis of carbazoles via a direct C-H amination process has been developed. A recyclable and inexpensive Cu-catalyst was successfully employed in N-heterocyclic compound synthesis via tandem azidation and C-H amination, which makes this protocol very practical and easy to handle.
- Ou, Yang,Jiao, Ning
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supporting information
p. 3473 - 3475
(2013/05/22)
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- Dioxomolybdenum(VI)-catalyzed reductive cyclization of nitroaromatics. Synthesis of carbazoles and indoles
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Reductive cyclization of nitrobiphenyls and nitrostyrenes to carbazoles and indoles, respectively, is carried out by triphenylphosphine under mild conditions catalyzed by a dichlorodioxomolybdenum(VI) complex. A one-pot procedure for the synthesis of regioselectively functionalized indoles has been developed from commercially available onitrobenzaldehydes and phosphoranes.
- Sanz, Roberto,Escribano, Jaime,Pedrosa, Maria R.,Aguado, Rafael,Arnaiz, Francisco J.
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p. 713 - 718
(2008/02/09)
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- Photo-Fries rearrangement of carbazol-2-yl sulfonates: Efficient tool for the introduction of sulfonyl groups into polycyclic aromatic compounds
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Systematic studies on the photo-Fries rearrangement of different 9H-carbazol-2-yl sulfonates 2 have shown that this type of conversion can be readily used for the preparative-scale introduction of alkyl- or arylsulfonyl groups into polycyclic aromatic compounds under very mild conditions. A series of new 1-sulfonyl- (3) or 3-sulfonyl-9H-carbazoles (4) were prepared in medium-to-good yields, and characterized by UV/VIS, 1H-NMR, and 13C-NMR spectroscopy, as well as by elemental analysis. Effects of irradiation wavelength, solvent polarity, presence or absence of O2, and photosensitizers were studied in detail.
- Crevatin, Laura K.,Bonesi, Sergio M.,Erra-Balsells, Rosa
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p. 1147 - 1157
(2007/10/03)
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- Use of ion channel modulating agents
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The present invention relates to the use of a particular class of chemical compounds as modulators of SKCa, IKCa and BKCa channels, and to pharmaceutical compositions comprising the SK/IK/BK channel modulating agents.
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- Diels-Alder reactions of 2- and 3-nitroindoles. A simple hydroxycarbazole synthesis
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A Diels-Alder reaction of 3- and 2-nitroindoles with Danishefsky's diene gives the expected 2- and 3-hydroxycarbazoles in very good to excellent yields (73-91%) and with apparent complete regioselectivity.
- Kishbaugh, Tara L.S,Gribble, Gordon W
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p. 4783 - 4785
(2007/10/03)
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- Flash Vacuum Pyrolysis of 5-(Indol-2- and -3-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-diones
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Flash vacuum pyrolysis of 5-(indol-2- and -3-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-diones results in the initial formation of indolylmethyleneketenes, which generally either lose carbon monoxide to produce ethynylindoles or undergo -sigmatropic shifts, followed by electrocyclic rearrangements, to yield carbazolols or benzindol-5(1H)-one. 5-(Indol-2-ylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione and the 3-methylindol-2-yl derivative both yield 3H-pyrroloindol-3-ones via a -sigmatropic rearrangement of the initially formed ketene.
- Benzies, David W. M.,Fresneda, Pilar Martinez,Jones, R. Alan,McNab, Hamish
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p. 1651 - 1654
(2007/10/02)
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- MUKONAL, A PROBABLE BIOGENETIC INTERMEDIATE OF PYRANOCARBAZOLE ALKALOIDS FROM MURRAYA KOENIGII
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Mukonal, a carbazole alkaloid has been isolated from Murraya koenigii.The structure of the compound has been established as 2-hydroxy-3-formyl carbazole based on physical (UV, IR, 1H NMR, 13C NMR and mass spectrometry) and chemical transformations. - Keywords: Murraya koenigii; Rutaceae; mukonal; carbazole alkaloid.
- Bhattacharyya, P.,Chakraborty, A.
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p. 471 - 472
(2007/10/02)
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