145372-32-3

Basic information

• Product Name: (1R,1'S)-Octahydro-1-(2'-iodo-1'-Methylethyl)-7a-Methyl-inden-4-one
• Synonyms: (1R,1'S)-Octahydro-1-(2'-iodo-1'-Methylethyl)-7a-Methyl-inden-4-one;[1R-[1α(S*),3aβ,7aα]]-Octahydro-1-(2-iodo-1-Methylethyl)-7a-Methyl-H-inden-4-one
• CAS NO: 145372-32-3
• Molecular Formula: C₁₃H₂₁IO
• Molecular Weight: 320.20971
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 145372-32-3.mol

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Ethyl Acetate, Methanol
• CAS DataBase Reference: (1R,1'S)-Octahydro-1-(2'-iodo-1'-Methylethyl)-7a-Methyl-inden-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,1'S)-Octahydro-1-(2'-iodo-1'-Methylethyl)-7a-Methyl-inden-4-one(145372-32-3)
• EPA Substance Registry System: (1R,1'S)-Octahydro-1-(2'-iodo-1'-Methylethyl)-7a-Methyl-inden-4-one(145372-32-3)

Safety Data

• Hazardous Substances Data: 145372-32-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1R,1'S)-Octahydro-1-(2'-iodo-1'-Methylethyl)-7a-Methyl-inden-4-one is used as an intermediate for the synthesis of Dihydroxyvitamin D3 and its metabolites, which are essential for various biological functions, including calcium and phosphorus homeostasis, bone metabolism, and immune system regulation. Its role in the pharmaceutical industry is crucial for the development of treatments for conditions related to vitamin D deficiency and bone disorders.
Used in Chemical Research:
As a complex organic compound, (1R,1'S)-Octahydro-1-(2'-iodo-1'-Methylethyl)-7a-Methyl-inden-4-one may also be used in chemical research for understanding its properties, reactivity, and potential applications in the synthesis of other compounds. Its unique structure could provide insights into new chemical reactions and pathways, contributing to the advancement of organic chemistry.

Upstream product

• 64190-52-9 (8S,20S)-de-A,B-20-(hydroxymethyl)pregnan-8-ol 
• 116535-65-0 (1R,3aR,4S,7aR)-octahydro-1-[(S)-1-iodopropan-2-yl]-7a-methyl-1H-inden-4-ol 

Downstream Products

• 1263286-76-5 (1R,3R,7E,22E,24E)-24a-homo-19-nor-9,10-secoergosta-5,7,22,24-tetraen-1,3,25-triol 
• 1263286-75-4 (1R,3R,7E,22E,24E)-24a-homo-19-nor-9,10-secoergosta-5,7,22,24-tetraen-1,3,25-triol 
• 132015-95-3 (1R,3R,7E,22E,24R)-24-methyl-19-nor-9,10-secocholesta-5,7,22-triene-1,3,25-triol 
• 1263286-72-1 (7E)-(1R,3R)-24-phenylsulfonyl-1,3-bis(tert-butyldimethylsililoxy)-9,10-seco-19,22,23-trinorchola-5,7-dien 
• 1263286-73-2 (7E)-(1R,3R)-24-phenylsulfonyl-9,10-seco-19,22,23-trinorchola-5,7-dien-1,3-diol 
• 131918-61-1 paricalcitol 
• 1263286-71-0 (7aR)-7a-methyl-1-((S)-1'-(phenylsulfonyl)propane-2'-yl)hexahydro-1H-inden-4(2H)-on 
• 145372-43-6 1α-[(tert-butyldimethylsilyl)oxy]-24-(methoxycarbonyl)-25,26,27-trisnorvitamin D3 tert-butyldimethylsilyl ether 
• 145372-41-4 1α-<(tert-butyldimethylsilyl)-oxy>-6,7-didehydro-24-(methoxycarbonyl)-25,26,27-trisnorprevitamin D₃ tert-butyldimethylsilyl ether 
• 145372-34-5 methyl-des-A,B-8-<(trifluoromethanesulfonyl)oxy>chol-8-ene-24-carboxylate 

Relevant articles and documents

NEW SYNTHONES FOR PREPARATION OF 19-NOR VITAMIN D DERIVATIVES

The present invention discloses the synthone of Formula (I), wherein R1 and R2 are the same or different and represent independently hydrogen atom or hydroxyl protecting group, and its use for preparation of 19-nor vitamin D derivatives of general Formula (IV), wherein represents single or double bond, p represents an integer 0 to 3, R1 and R2 represent independently hydrogen atom or hydroxyl protecting group, R3 represents hydrogen atom, CH3 or hydroxyl group, R4, R5 and R6 represent independently hydrogen atom, C1-C3-alkyl or hydroxyl group or two of R4, R5 and R6 substituents altogether form cyclopropyl group, in particular for preparation of paricalcitol.

Ultrasonically Induced Conjugate Addition of Iodides to Electron-Deficient Olefins and Its Application to the Synthesis of Side-Chain Analogs of the Hormone 1α,25-Dihydroxyvitamin D3

A versatile method for the rapid construction of fragments related to the upper part of vitamin D3 from the Lythgoe-Inhoffen diol is described.The key feature of the strategy is a new zinc-copper-induced conjugate addition of iodo triflate 10a to electron-deficient olefins under sonochemical aqueous conditions.These fragments are rapidly and efficiently transformed via the dienyne convergent approach to several derivatives of the hormone 1α,25-(OH)2-D3 modified at C-25.