14538-56-8

Basic information

• Product Name: Piperazine phosphate
• Synonyms: PIPERAZINE PHOSPHATE;piperazinium dihydrogen phosphate;Einecs 238-572-0;Piperazine, phosphate (1:1);Piperazine Phosphate (200 mg);Piperazine Phosphate
• CAS NO: 14538-56-8
• Molecular Formula: C₄H₁₀N₂*2H₃O₄P
• Molecular Weight: 184.13
• EINECS: 238-572-0
• Product Categories: Piperidines, Piperidones, Piperazines
• Mol File: 14538-56-8.mol

Chemical Properties

• Melting Point: 224-226 C
• Boiling Point: 468.9 °C at 760 mmHg
• Flash Point: 237.4 °C
• Appearance: Gray power
• Vapor Pressure: 4.36E-10mmHg at 25°C
• CAS DataBase Reference: Piperazine phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine phosphate(14538-56-8)
• EPA Substance Registry System: Piperazine phosphate(14538-56-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 14538-56-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Piperazine phosphate is used as an anthelmintic agent for the treatment of parasitic worm infections. It is particularly effective against various types of helminths, including roundworms, pinworms, and hookworms. The compound works by disrupting the energy metabolism of the parasites, leading to their paralysis and subsequent elimination from the host's body.
Used in Anthelmintic Applications:
Piperazine phosphate is used as an anthelmintic agent for the treatment of parasitic worm infections in both humans and animals. It is effective against a wide range of helminths, making it a versatile and widely used compound in the treatment of such infections.
Used in Veterinary Medicine:
In veterinary medicine, piperazine phosphate is used as an anthelmintic agent to treat parasitic worm infections in livestock and pets. It is commonly used in the treatment of gastrointestinal parasites, which can cause significant health issues in animals if left untreated.
Brand Names:
Some of the brand names under which piperazine phosphate is marketed include Pincets (Marion Merrell Dow) and Pinsirup (Marion Merrell Dow). These products are specifically formulated for the treatment of parasitic worm infections in humans and animals, respectively.
In addition to its use as an anthelmintic agent, piperazine and its derivatives have been found to possess high antiserotonin potency, antimicrobial activity, and potential anticancer activity in humans. This suggests that further research and development could lead to the discovery of new applications for piperazine phosphate in various industries, including pharmaceuticals and healthcare.

InChI:InChI=1/C4H10N2.H3O4P/c1-2-6-4-3-5-1;1-5(2,3)4/h5-6H,1-4H2;(H3,1,2,3,4)/p-2

Upstream product

• 110-85-0 piperazine 
• 86119-84-8 phosphoric acid 

Downstream Products

• 66034-17-1 piperazine pyrophosphate 
• 94159-17-8 melamine pyrophosphate 

Relevant articles and documents

Growth, nonlinear optical, thermal, dielectric and laser damage threshold studies of semiorganic crystal: Monohydrate piperazine hydrogen phosphate

Monohydrate piperazine hydrogen phosphate (MPHP), a semi organic nonlinear optical material has been synthesized and single crystals were grown from aqueous solution by slow evaporation technique. Single crystal X-ray diffraction study on grown crystal reveals that they belong to monoclinic crystal system with space group P21/c; (a = 6.39 A; b = 12.22 A; c = 11.16 A; β = 97.14°; V = 864 A3). The structural perfection of the grown crystal was analyzed by high-resolution X-ray diffraction (HRXRD) rocking curve measurements. FTIR spectrum confirms the presence of the functional groups in synthesized material. UV-Vis spectrum indicates that the crystal is transparent in the entire visible region with a lower cut off wavelength of 387 nm. The variation of dielectric properties of the grown crystal with respect to frequency has been investigated at different temperatures. Thermal analysis carried out on the MPHP crystal shows that the crystal is stable up to 135°C. Relative powder second harmonic generation efficiency tested by Kurtz-Perry powder technique, which was about 0.638 times that of Potassium dihydrogen phosphate.

Microwave-assisted synthetic method of pyrophosphate piperazine

The invention relates to a microwave-assisted synthetic method of pyrophosphate piperazine. The specific method comprises the steps of diphosphate piperazine synthesis by phosphoric acid and piperazine in the water, and then the diphosphate piperazine is placed under microwave-assisted heating for dehydration in the vacuum state, to achieve pyrophosphate piperazine synthesis. The invention directly uses microwave to heat from the internal diphosphate piperazine molecule by adopting microwave-assisted heating method, simultaneous heating and warming from internal and external of the materials could be achieved no need of any heat conduction process, the heating speed is fast and even, conducive to implementation of dehydraton reaction and to get pyrophosphate piperazine; compared to the traditional heating method, its energy consumption only requires a fraction or several tenths of the traditional heating method to achieve the heating purpose of the same effect, which greatly reduces the costs and improves economic benefit. In addition, weight loss temperature for the products acquired is significantly improved, and the product heat stability is greatly improved compared to the products under the current technology. This method is featured with less pollution, low energy consumption and good product heat stability.

Preparation method of pyrophosphate piperazine

The invention discloses a preparation method of pyrophosphate piperazine. The preparation method comprises the following steps: mixing ammonium dihydrogen phosphate and piperazine in an aqueous solution according to a mole ratio of 2:1, heating to remove ammonia, and dewatering for condensation to obtain the pyrophosphate piperazine. According to the preparation method, the shortcomings that conventional liquid phosphoric acid serving as a phosphorous source is difficult to transport and store are overcome; a reaction system is a weak-alkaline environment, so that erosion of the phosphoric acid serving as the phosphorous source to equipment is avoided; ammonia released during reaction can be used as protection atmosphere of the reaction system, and the whiteness value of a product meets the market requirement. Compared with a phosphoric acid-piperazine method, the preparation method has the advantage of saving the raw material cost by 10 to 15 percent.

High purity pyrophosphorate piperazinecarboxylic and flame retardant synthetic resin composition

PROBLEM TO BE SOLVED: To provide high purity piperazine pyrophosphate giving a flame-retardant composition exhibiting excellent flame retardance, and to provide a method for economically producing the piperazine pyrophosphate. SOLUTION: There are provided piperazine pyrophosphate represented by chemical formula (I) and having a sodium content of 10 ppm or less and a production method for piperazine pyrophosphate, obtaining the piperazine pyrophosphate by dehydration condensation of piperazine diphosphate. COPYRIGHT: (C)2011,JPOandINPIT