145451-95-2

Basic information

• Product Name: (3R,4S,5S,6S)-1-Aza-5-(t-butyldimethylsilyloxymethyl)-4-hydroxy-6-isopropyl-3-methyl-7-oxabicyclo[3.3.0]-octan-2-one
• Synonyms: (3R,4S,5S,6S)-1-Aza-5-(t-butyldimethylsilyloxymethyl)-4-hydroxy-6-isopropyl-3-methyl-7-oxabicyclo[3.3.0]-octan-2-one;[1S-(1α,6α,7α,7aα)]-7a-[[[(1,1-DiMethylethyl)diMethylsilyl]oxy]Methyl]tetrahydro-7-hydroxy-6-Methyl-1-(1-Methylethyl)-3H,5H-pyrrolo[1,2-c]
• CAS NO: 145451-95-2
• Molecular Formula: C17H33NO4Si
• Molecular Weight: 328.46686
• Product Categories: Chiral Reagents;Intermediates;Heterocycles
• Mol File: 145451-95-2.mol

Chemical Properties

• Melting Point: 98-99°C
• Boiling Point: 438.025 °C at 760 mmHg
• Flash Point: 218.71 °C
• Appearance: /
• Density: 1.064 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.496
• CAS DataBase Reference: (3R,4S,5S,6S)-1-Aza-5-(t-butyldimethylsilyloxymethyl)-4-hydroxy-6-isopropyl-3-methyl-7-oxabicyclo[3.3.0]-octan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S,5S,6S)-1-Aza-5-(t-butyldimethylsilyloxymethyl)-4-hydroxy-6-isopropyl-3-methyl-7-oxabicyclo[3.3.0]-octan-2-one(145451-95-2)
• EPA Substance Registry System: (3R,4S,5S,6S)-1-Aza-5-(t-butyldimethylsilyloxymethyl)-4-hydroxy-6-isopropyl-3-methyl-7-oxabicyclo[3.3.0]-octan-2-one(145451-95-2)

Safety Data

• Hazardous Substances Data: 145451-95-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C17H33NO4Si/c1-11(2)14-17(9-22-23(7,8)16(4,5)6)13(19)12(3)15(20)18(17)10-21-14/h11-14,19H,9-10H2,1-8H3/t12-,13+,14+,17+/m1/s1

Upstream product

• 203934-88-7 (2R,3S)-3-[(4S,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-3-hydroxy-2-methyl-propionic acid methyl ester 
• 145451-93-0 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carboxylic acid methyl ester 
• 145451-90-7 (2R,4R)-3-Benzyl-2-tert-butyl-4-((S)-1-hydroxy-2-methyl-propyl)-oxazolidine-4-carboxylic acid methyl ester 
• 145451-91-8 (2R,3S)-2-Benzylamino-3-hydroxy-2-hydroxymethyl-4-methyl-pentanoic acid methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 145484-22-6 (4R,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidine-4-carbaldehyde 
• 154226-59-2 (2R,3S)-3-[(4S,5S)-3-Benzyl-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-isopropyl-oxazolidin-4-yl]-3-hydroxy-2-methyl-propionic acid (R)-1,2,2-triphenyl-2-trimethylsilanyloxy-ethyl ester 

Downstream Products

• 145451-96-3 (1S,6R,7S,7aS)-7-Hydroxy-1-isopropyl-6-methyl-5-oxo-dihydro-pyrrolo[1,2-c]oxazole-7a-carboxylic acid 
• 154226-60-5 omuralide 
• 133343-34-7 Lactacystin 
• 145452-03-5 (1S,6R,7S,7aS)-7-Hydroxy-1-isopropyl-6-methyl-5-oxo-dihydro-pyrrolo[1,2-c]oxazole-7a-carbaldehyde 
• 145451-97-4 (3R,4S,5R,1'S)-4-hydroxy-5-(1'-hydroxy-2'-methylpropyl)-3-methylpyrrolidin-2-one-5-carboxylic acid 
• 145452-02-4 (1S,6R,7S,7aS)-7-Hydroxy-7a-hydroxymethyl-1-isopropyl-6-methyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one 

Relevant articles and documents

A new magnesium-catalyzed doubly diastereoselective anti-aldol reaction leads to a highly efficient process for the total synthesis of lactacystin in quantity

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STUDIES ON THE TOTAL SYNTHESIS OF LACTACYCLIN. AN IMPROVED ALDOL COUPLING REACTION AND A β-LACTONE INTERMEDIATE IN THIOL ESTER FORMATION

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