- Synthesis of a tetrasubstituted tetrahydronaphthalene scaffold for α-helix mimicry via a MgBr2-catalyzed Friedel-Crafts epoxide cycloalkylation
-
α-Helices are ubiquitous protein recognition elements that bind diverse biomolecular targets. The synthesis of a small molecule scaffold to present the side chains of an α-helix is described. The 1,3,5,7-tetrasubstituted 1,2,3,4-tetrahydronaphthalene scaf
- Naduthambi, Devan,Bhor, Santosh,Elbaum, Michael B.,Zondlo, Neal J.
-
supporting information
p. 4892 - 4895
(2013/10/08)
-