- Design, Synthesis and Self-Assembly of Functional Amphiphilic Metallodendrimers
-
A new family of alkynylated, amphiphilic dendrimers consisting of amidoamine linkers connected to 5,5′-functionalized 2,2′-bipyridine cores has been developed and evaluated in the formation of metallodendrimers of different generations and in self-assembly protocols. A convergent synthetic strategy was applied to provide dumbbell-shaped amphiphilic dendrimers, where the 2,2′-bipyridine cores could be coordinated to FeII centers to afford corresponding metallodendrimers. The ability of the metallic- and non-metallic dendritic structures to self-assemble into functional supramolecular aggregates were furthermore evaluated in aqueous solution. Spherical aggregates with sizes of a few hundred nanometers were generally produced, where controlled disassembly of the metallodendrimers through decomplexation could be achieved.
- Alberch, Laura,Neranon, Kitjanit,Ramstr?m, Olof
-
-
Read Online
- Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry
-
Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%. The Royal Society of Chemistry 2005.
- Rijkers, Dirk T. S.,Van Esse, G. Wilma,Merkx, Remco,Brouwer, Arwin J.,Jacobs, Hans J. F.,Pieters, Roland J.,Liskamp, Rob M. J.
-
-
Read Online
- Polyhydroxybenzoic acid derivatives as potential new antimalarial agents
-
With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malaria since 2015 (from 211 million in 2015 to 229 million in 2019). This trend could partially be due to the development of resistance to all the current drugs. Therefore, there is an urgent need for new alternatives. We have, thus, selected common natural scaffolds, polyhydroxybenzoic acids, and synthesized a library of derivatives to better understand the structure–activity relationships explaining their antiplasmodial effect. Only gallic acid derivatives showed a noticeable potential for further developments. Indeed, they showed a selective inhibitory effect on Plasmodium (IC50 ~20 μM, SI > 5) often associated with interesting water solubility. Moreover, this has confirmed the critical importance of free phenolic functions (pyrogallol moiety) for the antimalarial effect. Methyl 4-benzoxy-3,5-dihydroxybenzoate (39) has, for the first time, been recognized as a potential lead for future research because of its marked inhibitory activity against Plasmodium falciparum and its significant hydrosolubility (3.72 mM).
- Degotte, Gilles,Francotte, Pierre,Pirotte, Bernard,Frédérich, Michel
-
-
- One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
-
Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mechanical properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the "PEG dilemma", and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodology and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technology often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5 °C and demonstrated higher transfection efficiency than positive control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.
- Atochina-Vasserman, Elena N.,Billingsley, Margaret M.,Huang, Ning,Kim, Kyunghee,Liu, Matthew,Maurya, Devendra S.,Mitchell, Michael J.,Ni, Houping,Ona, Nathan,Percec, Virgil,Pochan, Darrin J.,Shahnawaz, Hamna,Weissman, Drew,Xiao, Qi,Zhang, Dapeng
-
supporting information
p. 12315 - 12327
(2021/08/20)
-
- α-D-Mannoside ligands with a valency ranging from one to three: Synthesis and hemagglutination inhibitory properties
-
Six mono-, di-, and trivalent α-D-mannopyranosyl conjugates built on aromatic scaffolds were synthesized in excellent yields by Cu(I) catalyzed azide-alkyne cycloaddition reaction (CuAAC). These conjugates were designed to have unique, flexible tails that combine a mid-tail triazole ring, to interact with the tyrosine gate, with a terminal phenyl group armed with benzylic hydroxyl groups to avoid solubility problems as well as to provide options to connect to other supports. Biological evaluation of the prepared conjugates in hemagglutination inhibition (HAI) assay revealed that potency increases with valency and the trivalent ligand 6d (HAI = 0.005 mM) is approximately sevenfold better than the best meta-oriented monovalent analogues 2d and 4d (HAI ≈ 0.033 mM) and so may serve as a good starting point to find new lead ligands.
- Al-Mughaid, Hussein,Khazaaleh, Maha
-
-
- Scalable Total Synthesis of Piceatannol-3′-O-β-d-glucopyranoside and the 4′-Methoxy Congener Thereof: An Early Stage Glycosylation Strategy
-
Scalable syntheses of piceatannol-3'-O-β-D-glucopyranoside and the 4'-methoxy congener thereof were achieved. This route features an early implemented Fischer-like glycosylation reaction, a regioselective iodination of phenolic glycoside under strongly acidic conditions, a highly telescoped route to access the styrene derivative, and a key Mizoroki.Heck reaction to render the desired coupled products in high overall yield.
- Chen, Lei,Li, Jianfeng,Wang, Xiaoting,Zhang, Rong-Ping
-
-
- Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
-
Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step of genetic nanomedicine. The four-component lipid nanoparticle synthetic delivery systems consisting of ionizable lipids, phospholipids, cholesterol, and a PEG-conjugated lipid, assembled by microfluidic or T-tube technology, have been extraordinarily successful for delivery of mRNA to provide Covid-19 vaccines. Recently, we reported a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) synthetic delivery system for mRNA relying on amphiphilic Janus dendrimers and glycodendrimers developed in our laboratory. Amphiphilic Janus dendrimers consist of functional hydrophilic dendrons conjugated to hydrophobic dendrons. Co-assembly of IAJDs with mRNA into dendrimersome nanoparticles (DNPs) occurs by simple injection in acetate buffer, rather than by microfluidic devices, and provides a very efficient system for delivery of mRNA to lung. Here we report the replacement of most of the hydrophilic fragment of the dendron from IAJDs, maintaining only its ionizable amine, while changing its interconnecting group to the hydrophobic dendron from amide to ester. The resulting IAJDs demonstrated that protonated ionizable amines play dual roles of hydrophilic fragment and binding ligand for mRNA, changing delivery from lung to spleen and/or liver. Replacing the interconnecting ester with the amide switched the delivery back to lung. Delivery predominantly to liver is favored by pairs of odd and even alkyl groups in the hydrophobic dendron. This simple structural change transformed the targeted delivery of mRNA mediated with IAJDs, from lung to liver and spleen, and expands the utility of DNPs from therapeutics to vaccines.
- Zhang, Dapeng,Atochina-Vasserman, Elena N.,Maurya, Devendra S.,Liu, Matthew,Xiao, Qi,Lu, Juncheng,Lauri, George,Ona, Nathan,Reagan, Erin K.,Ni, Houping,Weissman, Drew,Percec, Virgil
-
supporting information
p. 17975 - 17982
(2021/11/10)
-
- Total Synthesis of Isohericenone J via a Stille Coupling Reaction
-
The first total synthesis of isohericenone J is reported. Key features of this synthetic strategy are a Friedel-Crafts reaction to construct the isobenzofuranone unit and a Pd-catalyzed Stille coupling reaction for the formation of the C5-C1′ bond, generating the natural product, as well as one of its isomers, in 6.0% overall yield in eight steps. This strategy provides a foundation for the synthesis of challenging isobenzofuranone and isoindolinone-type derivatives.
- Cao, Wei,Chen, Ping,Tang, Yu
-
p. 1701 - 1705
(2020/06/08)
-
- An expeditious click approach towards the synthesis of galactose coated novel glyco-dendrimers and dentromers utilizing a double stage convergent method
-
The primary motive behind this article is to bring to the forefront a unique kind of dendrimer which has remained a dark horse since its discovery, namely dentromer. We herein report the synthesis of glycodendrimers and glycodentromers crowned with galactose units by harnessing an expeditious synthesis of dendrimer core 18 and dentromer core 19, divergently with branching directionality (1 → 2) and (1 → 3), respectively. A competent, double stage convergent synthetic path was chosen to facilitate ease of refining and spectroscopic elucidations. By exploiting a Cu(i)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction strategy, we successfully developed a new series of galactosylated dendrimers 20, 21, 22, and 24 containing 6, 12, 18, and 18 peripheral galactose units, respectively. We are first to report the practical synthesis of 9-peripheral galactose coated glycodentromer 23 (0th generation) and 27-peripheral galactose coated glycodentromer 25 (1st generation). These synthesized scaffolds were characterized by spectral studies such as 1H, 13C NMR, FT-IR, MALDI-TOF MS, HRMS and SEC analysis. Additionally, gel permeation chromatography depicted the regular progression in size from 6 to 27-peripheral galactose coated glycodendrimers along with glycodentromers, with their high monodispersity. Also, the glyco-dendrimers and dentromers synthesized from two different hypercore units i.e. dendrimers core (18) and dentromer core (19), have been supported by their UV-visible absorbance and emission spectroscopy. This journal is
- Agrahari, Anand K.,Mukherjee, Rishav,Singh., Anoop S.,Tiwari, Vinod K.
-
p. 31553 - 31562
(2020/09/21)
-
- Synthesis of Benzo[ b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis
-
One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogues, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.
- Henry, Martyn C.,Sutherland, Andrew
-
supporting information
p. 2766 - 2770
(2020/03/30)
-
- Synthesis of flutamide-conjugates
-
In this paper, we designed and extended modification basing on the flutamide structure. A series of flutamide-conjugates were obtained with methyl bromoacetate and ethylenediamine. Through the synthesis of two conjugates with 3,5-bis(dodecyloxy)benzoate derivatives, these flutamide conjugates were tested for anticancer activity. Among the compounds tested, the flutamide-conjugates showed good inhibition activity against cancer cell lines U-251, PC-3 and K-562. The conjugates showed a better inhibitory effect than free flutamide and did not show activity against normal COS-7 monkey kidney fibroblast cells. It was also observed that the flutamide conjugates had an inhibitory effect against human colorectal adenocarcinoma HCT-15.
- Castillo-Rodríguez, Irving Osiel,Hernández-Ortega, Simón,Martínez-García, Marcos,Martínez-Klimova, Elena,Medina-Rojas, Julio César,Ramírez-ápan, Teresa
-
supporting information
(2020/09/09)
-
- Design, synthesis, in vitro and in silico studies of 2, 3-diaryl benzofuran derivatives as antitubercular agents
-
As a part of our drug discovery program for anti-tubercular agents, a total of seventeen 2, 3-diaryl benzofuran hybrids were designed, synthesized and screened for their anti-tubercular potential against Mycobacterium tuberculosis H37Ra avirulent strain. Out of seventeen, four derivatives showed significant activity against M. tuberculosis H37Ra avirulent strain (ATCC 25177) with MIC value ranging from 12.5 to 50 μg/mL but out of four, one derivative (9E) was significantly active (MIC 12.5 μg/mL), which was further supported by the molecular docking energy (?8.4 kcal/mol) with respect to the first line anti-tubercular drug, isoniazid (?6.2 kcal/mol) on the target Polyketide Synthase-13. All the derivatives were also evaluated for their cytotoxicity against the normal lung cell line L-132 by the MTT assay and no toxicity was observed up to 27.4 μg/mL concentration. This report on the antitubercular potential of benzofuran derivatives may be of great help in anti-tubercular drug development.
- Bhukya, Balakishan,Shukla, Aparna,Chaturvedi, Vinita,Trivedi, Priyanka,Kumar, Shailesh,Khan, Feroz,Negi, Arvind S.,Srivastava, Santosh Kumar
-
-
- Dendritic architectures by orthogonal thiol-maleimide "click" and furan-maleimide dynamic covalent chemistries
-
A set of dendrons and dendrimers is synthesized divergently using an orthogonal combination of kinetically-driven thiol-maleimide "click" chemistry and thermodynamically reversible furan-maleimide cycloaddition/retrocycloaddition reactions. Growth is controlled by taking advantage of the selective thiol-ene addition of thiols to the electron withdrawn alkene of maleimide in the presence of electron rich alkene of oxanorbornene. Subsequent activation of growing dendrons/dendrimers requires only heat to induce the dynamic covalent liberation of peripheral furan protecting groups. The methodology introduced provides a new route to multifunctional dendrimers that could, in principle, be synthesized by introducing different branched monomers at any stage of dendrimer growth, allowing dendrimer architectures and properties to be better tailored to their intended applications.
- Frayne, Stephen H.,Stolz, Robert M.,Northrop, Brian H.
-
supporting information
p. 7878 - 7883
(2019/09/06)
-
- Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates
-
It is urgently necessary to develop more effective anti-influenza agents due to the continuous emergence of drug-resistant strains of influenza virus. Our earlier studies have identified that certain pentacyclic triterpene derivatives are effective inhibitors of influenza virus infection. In the present study, a series of C-28 modified pentacyclic triterpene derivatives via conjugation with a series of polyphenols were synthesized, and their antiviral activities against influenza A/WSN/33 (H1N1) virus in MDCK (Madin-Darby canine kidney) cells were evaluated. Four compounds 23m, 23o, 23q and 23s displayed robust anti-influenza potency with averaged IC50 values at the low-micromole level, surpassing the potency of oseltamivir. In addition, the in vitro cytotoxic activity of the four conjugates against MDCK cells showed no toxicity at 100 μM. Further mechanism studies of compound 23s, one of the best representative conjugates with IC50 value of 5.80 μM and a selective index (SI) value of over 17.2, by hemagglutination inhibition (HI), surface plasmon resonance and molecular modeling indicated that this conjugate bound tightly to the viral envelope hemagglutinin (KD = 15.6 μM), thus blocking the invasion of influenza viruses into host cells.
- Li, Haiwei,Li, Man,Xu, Renyang,Wang, Shouxin,Zhang, Yongmin,Zhang, Lihe,Zhou, Demin,Xiao, Sulong
-
p. 560 - 568
(2019/01/03)
-
- DIARYL TREHALOSE COMPOUNDS AND USES THEREOF
-
Disclosed herein are diaryl trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
- -
-
Paragraph 00262
(2019/09/12)
-
- Bioinspired Amphiphilic Peptide Dendrimers as Specific and Effective Compounds against Drug Resistant Clinical Isolates of E. coli
-
Evolution-derived natural compounds have been inspirational for design of numerous pharmaceuticals, e.g., penicillins and tetracyclines. Herein, we present a bioinspired strategy to design peptide dendrimers for the effective therapy of E. coli infections where the selection of appropriate amino acids and the mode of their assembly are based on the information gained from research on membranolytic natural antimicrobial peptides (AMP's). On the molecular level two opposite effects were explored: the effect of multiple positive charges necessary for membrane disintegration was equilibrated by the anchoring role of tryptophanes. Indeed, a series of Trp-terminated dendrimers exhibited high potency against clinical isolates of antibiotic resistant ESBL E. coli strains, stability in human plasma along with very low hemo- and genotoxicity. Investigation of the underlying antimicrobial mechanism indicated that the dendrimers studied at minimal inhibitory concentration showed weak permeability toward membranes. Solid-state 2D NMR studies revealed their presence on and inside the model membranes. Therefore, their biological properties might be explained by targeting of extra- or intracellular receptors. Our results point to a new approach to design novel branched antimicrobials with high therapeutic index.
- Sowińska, Marta,Laskowska, Anna,Gu?piel, Adam,Solecka, Jolanta,Bochynska-Czyz, Marta,Lipkowski, Andrzej W.,Trzeciak, Katarzyna,Urbanczyk-Lipkowska, Zofia
-
p. 3571 - 3585
(2018/10/24)
-
- PROTEIN AGGREGATION INHIBITOR AND PROTEIN AGGREGATION INHIBITING METHOD
-
PROBLEM TO BE SOLVED: To provide a protein aggregation inhibitor capable of inhibiting protein aggregation and preparing a protein solution with a low viscosity. SOLUTION: The protein aggregation inhibitor contains a compound represented by the general formula (1) in the figure. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
- -
-
Paragraph 0252; 0254; 0263
(2018/02/27)
-
- Cancerous Cell Growth Inhibiting Compounds
-
The present invention provides a compound of Formula I, II or III or a salt or prodrug or derivative thereof that is useful for skin-whitening by inhibiting melanin formation and removing existing melanin and the inhibition of melanoma growth and/or the removal of existing melanoma cells.
- -
-
Paragraph 0176
(2018/01/03)
-
- Synthesis and antioxidant activity of 1,3,4-oxadiazoles and their diacylhydrazine precursors derived from phenolic acids
-
Eight 1,3,4-oxadiazole derivatives containing phenolic acid moieties (7a-h) and eight of their diacylhydrazine precursors (6a-h) were synthesized, characterized using spectroscopic methods and examined by scavenging of stable DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals. The most potent phenolic 1,3,4-oxadiazoles showed better DPPH scavenging activity in comparison with their corresponding diacylhydrazine precursors as a result of participation of both aromatic rings and a 1,3,4-oxadiazole moiety in resonance stabilization of the formed phenoxyl radical. Four diacylhydrazines (6d, 6e, 6g, and 6h) and four 1,3,4-oxadiazoles (7d, 7e, 7g and 7h) with the best DPPH scavenging activity, were chosen for further evaluation of their antioxidant potential through various assays. The investigated compounds exerted pronounced ABTS radical scavenging capacity, moderate to good H2O2 scavenging properties and strong ferric ion reducing capacity. Further in vitro evaluation of the antioxidant properties of the most active compounds demonstrated their protective effects in normal lung fibroblasts MRC-5 against hydrogen peroxide induced oxidative stress. Diacylhydrazine 6h increased two times the activity of glutathione peroxidase in treated cells in comparison with a control sample and did not affect the superoxide dismutase activity.
- Mihailovi?, Nevena,Markovi?, Violeta,Mati?, Ivana Z.,Stanisavljevi?, Nemanja S.,Jovanovi?, ?ivko S.,Trifunovi?, Sne?ana,Joksovi?, Ljubinka
-
p. 8550 - 8560
(2017/02/10)
-
- Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties
-
DNA-encoded chemical libraries are increasingly used to identify leads for drug discovery or chemical biology. Despite the resurging interest in covalent inhibitors, libraries are typically designed with synthon filtered out for reactive functionalities that can engage a target through covalent interactions. Herein, we report the synthesis of two libraries containing Michael acceptors to identify cysteine reactive ligands. We developed a simple procedure to discriminate between covalent and high affinity non-covalent inhibitors using DNA display of the library in a microarray format. The methodology was validated with known covalent and high affinity non-covalent kinase inhibitors. Screening of the library revealed novel covalent inhibitors for MEK2 and ERBB2.
- Zambaldo,Daguer,Saarbach,Barluenga,Winssinger
-
p. 1340 - 1351
(2016/07/21)
-
- A facile and practical total synthetic route for ampelopsin F and permethylated ?-viniferin
-
Stilbene dimers (±)-ampelospin F and permethylated (±)-?-viniferin were synthesized by a practical synthetic route with overall yields of 10% and 27%. This route involves triethylsilane-mediated reduction of the 2,3-diarylbenzofuran, and BBr3-mediated one-pot demethylation and cascade intramolecular cyclization reaction.
- Zhang, Jifa,Zhang, Jianqiao,Kang, Yulong,Shi, Jiangong,Yao, Chunsuo
-
supporting information
p. 1587 - 1591
(2016/06/14)
-
- Formation of a Polythreaded, Metal–Organic Framework Utilizing an Interlocked Hexadentate, Carboxylate Linker
-
A unique hexacarboxylate linker was prepared on the basis of an interlocked [2]rotaxane motif. The linker contains four carboxylate groups attached to a rigid, H-shaped axle and two carboxylate units appended to a crown ether wheel. The resulting ZnII-based metal–organic framework material has a unique lattice, in which three independent 3-periodic frameworks (threefold interpenetration) are interconnected only by virtue of the threading of their individual components in the rotaxane linker.
- Gholami, Ghazale,Zhu, Kelong,Ward, Jas S.,Kruger, Paul E.,Loeb, Stephen J.
-
supporting information
p. 4524 - 4529
(2016/10/04)
-
- Ruthenium-Catalyzed Hydroarylation and One-Pot Twofold Unsymmetrical C?H Functionalization of Arenes
-
A methyl phenyl sulfoximine (MPS) is used as a directing group in the ruthenium-catalyzed intramolecular hydroarylation of alkene-tethered benzoic acid derivatives to afford dihydrobenzofurans and indolines in good to excellent yields. A one-pot, unsymmetrical, twofold C?H functionalization involving intramolecular C?C and intermolecular C?C/C?N bond formations is successfully demonstrated by using a single set of catalytic reaction conditions, which is unprecedented thus far. A novel isoquinolone-bearing dihydrobenzofuran is constructed through an unsymmetrical twofold C?H functionalization.
- Ghosh, Koushik,Ramesh, E.,Rit, Raja K.,Sahoo, Akhila K.
-
supporting information
p. 7821 - 7825
(2016/07/07)
-
- Synthesis of Curvulone B Using the 2-Chlorobenzyl Protecting Group
-
A total synthesis of curvulone B has been completed using a Friedel-Crafts reaction and a highly cis-selective intramolecular oxa-Michael addition. The 2-chlorobenzyl protecting group was employed and found to have much greater Lewis acid stability compared to the simple benzyl group.
- Bates, Roderick W.,Wang, Kongchen,Zhou, Guanying,Kang, Dave Zhihong
-
p. 751 - 754
(2015/03/30)
-
- Regioselective bromination: An approach to the D-ring of the gilvocarcins
-
A method for the regioselective ortho-bromination of unsymmetrically protected 3,5-dihydroxybenzoic acid esters has been developed. The route involves protecting group optimization studies to attain high regioselectivity for the ortho-bromination. Pd-catalyzed stannation and boration were performed to construct the D-ring coupling partners for the synthesis of gilvocarcin analogs.
- Sharif, Ehesan U.,O'Doherty, George A.
-
p. 1275 - 1285
(2016/11/11)
-
- OPTICAL IMAGING PROBES
-
The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
- -
-
Paragraph 0087; 0090; 0091
(2014/05/20)
-
- Effect of the bulkiness of the end functional amide groups on the optical, gelation, and morphological properties of oligo(p-phenylenevinylene) π-gelators
-
Herein, we describe the role of end functional groups in the self-assembly of amide-functionalized oligo(p-phenylenevinylene) (OPV) gelators with different end-groups. The interplay between hydrogen-bonding and π-stacking interactions was controlled by the bulkiness of the end functional groups, thereby resulting in aggregates of different types, which led to the gelation of a wide range of solvents. The variable-temperature UV/Vis absorption and fluorescence spectroscopic features of gelators with small end-groups revealed the formation of 1D H-type aggregates in CHCl3. However, under fast cooling in toluene, 1D H-type aggregates were formed, whereas slow cooling resulted in 2D H-type aggregates. OPV amide with bulky dendritic end-group formed hydrogen-bonded random aggregates in toluene and a morphology transition from vesicles into fibrous aggregates was observed in THF. Interestingly, the presence of bulky end-group enhanced fluorescence in the xerogel state and aggregation in polar solvents. The difference between the aggregation properties of OPV amides with small and bulky end-groups allowed the preparation of self-assembled structures with distinct morphological and optical features. Buying in bulk: OPV amides with small end-groups self-assemble into 2D/1D aggregates in toluene and 1D aggregates in CHCl3. Bulky end-groups impede fluorescence quenching in the self-assembled state by blocking π-stacking and facilitate morphological transition in THF.
- Babu, Sukumaran Santhosh,Praveen, Vakayil K.,Kartha, Kalathil K.,Mahesh, Sankarapillai,Ajayaghosh, Ayyappanpillai
-
supporting information
p. 1830 - 1840
(2014/07/08)
-
- Biomimetic synthesis of active isorhapontigenin dimers
-
Synthetic isorhapontigenin was treated with several kinds of inorganic reagents and peroxidase so as to prepare active stilbene dimers. Among them, silver acetate in methanol gave two new isorhapontigenin dimers 4 and 5, together with four known natural stilbene dimers 2, 3, 6, and 7. Their structures and relative configurations were determined on the basis of spectral analysis, and their possible formation mechanisms were discussed, respectively. Compounds 2, 6, and 7 were artificially synthesized for the first time. All the products were evaluated for anti-inflammatory activities.
- Wang, Xian-Fen,Zhang, Yuan,Lin, Ming-Bao,Hou, Qi,Yao, Chun-Suo,Shi, Jian-Gong
-
p. 511 - 521
(2014/06/09)
-
- AROMATIC RING COMPOUND
-
Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
- -
-
Paragraph 0357; 0358
(2015/01/18)
-
- Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV
-
Using hydroxy-/dihydroxybenzoic acids as leads, a series of methyl, ethyl and iso-propyl esters of 4-hydroxy-benzoic acid, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5-dihydroxybenzoic acids and of coumaric acid, were obtained and investigated for the inhibition of six mammalian carbonic anhydrase (CA, EC 4.2.1.1) isoforms, that is, the cytosolic CA I, II and VII, and the transmembrane CA IX, XII and XIV, many of which are established drug targets. Other compounds incorporating phenol/catechol moieties were obtained from dopamine by reaction with fluorescein isothiocyanate or with 2,4,6-trisubstituted pyrylium salts. Some aminophenols were also derivatized in a similar manner, by using pyrylium salts. Many of these compounds showed increased inhibitory action compared to the lead compounds from which they were obtained, with efficacy in the submicromolar range against most investigated CA isoforms. As phenols are a class of less investigated CA inhibitors (CAIs) compared to the sulfonamides, and their mechanism of inhibition is less well understood, compounds of the type designed here may be helpful in gaining more insights into these phenomena.
- Carta, Fabrizio,Vullo, Daniela,Maresca, Alfonso,Scozzafava, Andrea,Supuran, Claudiu T.
-
supporting information
p. 1564 - 1569
(2013/04/10)
-
- Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase
-
Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases. The Royal Society of Chemistry 2013.
- Avlonitis, Nicolaos,Debunne, Manuelle,Aslam, Tashfeen,McDonald, Neil,Haslett, Chris,Dhaliwal, Kevin,Bradley, Mark
-
supporting information
p. 4414 - 4418
(2013/08/23)
-
- Unexpected O-alkylation and ester migration in phenolic 2,3-diaryl-2,3-dihydrobenzo[b]furans
-
O-alkylation of 2-(4-methoxyphenyl)-5-hydroxy-3-[1,3-phenylene-bis(4- nitrobenzoate)]-2,3-dihydrobenzo[b]furan results in the unexpected hydrolysis of the nitrobenzoate esters, transfer of a 4-nitrobenzoic acid group to the 5-hydroxyl group and double alkylation of the newly formed 3,5-diphenol moiety. A range of alkyl halides can be used and give access to O-alkyl analogues of -viniferin.
- Tran, Henry,Dickson, Benjamin D.,Barker, David
-
p. 2093 - 2096
(2013/04/23)
-
- Synthesis of C- and O-prenylated tetrahydroxystilbenes and O-prenylated cinnamates and their action towards cancer cells
-
Synthesis of the naturally occurred C- and O-prenylated tetrahydroxystilbenes and O-prenylated cinnamates was carried out by decarbonylative Heck reaction and selenium dioxide catalysed oxidation, respectively. In the decarbonylative Heck synthetic route, fusion of benzoyl chloride and styrene derivatives was catalysed by an N-heterocyclic carbene system generated in situ by palladium acetate and 1,3-bis(2,6-diisopropylphenyl) imidazolinium chloride to form a E-tetrahydroxystilbene derivative. Formation of allyl ether was subsequently carried out by reaction of the deprotected OH in the A phenyl ring of the stilbene with 3,3-dimethylallyl bromide and a base (sodium hydride) to form O-prenylated tetrahydroxystilbene derivatives. [1,5]-Rearrangement of the isoprenyl unit from O- to C-position in the A ring was carried out at elevated temperature in the presence of magnesium silicate (Florisil) to form the corresponding C-prenylated tetrahydroxystilbene. Formation of O-prenylated cinnamate was first carried out by base catalysed allyl ether formation between 3,3-dimethylallyl bromide and hydroxycinnamic acid methyl ester. The methyl group of the isoprenyl unit was subsequently oxidized using selenium dioxide to form a terminal hydroxyl group. The prenylated tetrahydroxystilbenes and cinnamate synthesized in this study were novel derivatives of piceatannol and methyl 4-(3′-methylbut-2′-enyloxy) cinnamate isolated from propolis in Kangaroo Island, South Australia. The synthetic compounds were tested against K562 cancer cells and potent growth inhibitory activity was observed for E-1-[5-hydroxy-3-methoxy-2-(3-methyl-2- butenyl)phenyl]-2-[4-hydroxy-3-methoxyphenyl]ethene, IC50 = 0.10 μM.
- Koolaji, Nooshin,Abu-Mellal, Abdallah,Tran, Van H.,Duke, Rujee K.,Duke, Colin C.
-
supporting information
p. 415 - 422
(2013/07/27)
-
- Synthesis, structural characterization, and thermoresponsivity of hybrid supramolecular dendrimers bearing a polyoxometalate core
-
A series of cationic dendrons bearing triethylene glycol monomethyl ether terminal groups of different generations have been synthesized and used to encapsulate an inorganic polyanionic cluster [K12.5Na 1.5(NaP5W30O110)] through electrostatic interactions. The resulting dendritic cation-encapsulated polyoxometalate (POM) complexes, cluster-dendrimers, are soluble in water and exhibit lower critical solution temperatures (LCST). The thermoresponsivities of these complexes in aqueous solutions were studied by turbidimetry and variable-temperature 1H NMR spectroscopy. The observed cloud points show a remarkable dependence on the generation of the dendrons. Complexes composed of first-generation dendrons exhibit no obvious thermoresponsive properties, but for complexes bearing second-generation dendrons, the LCST decreases as the number of dendritic cations around the POM cluster increases. Complexes composed of third-generation cations underwent reversible aggregation and disaggregation upon heating and cooling, respectively. This thermally induced self-aggregation was characterized by DLS and TEM. In addition, the effects of salt and solvent on the LCST were investigated. This research demonstrates a new type of thermoresponsive dendritic organic-inorganic hybrid complex and provides a general route to the endowment of POMs with temperature-sensitive properties through electrostatic interactions.
- Chen, Hailong,Yang, Yang,Wang, Yizhan,Wu, Lixin
-
supporting information
p. 11051 - 11061
(2013/09/02)
-
- A new synthesis of 4′-resveratrol esters and evaluation of the potential for anti-depressant activity
-
The 4′-ester analog of the disease preventative resveratrol 1 (RV), 4′-acetyl-RV 2 along with 4′-pivaloate 13 and benzoate 14 RV were synthesized. The previously developed palladium catalyzed decarbonylative Heck coupling was used to assemble the stilbene core together with 3,5-dibenzyl protected phenol intermediates that allowed for efficient coupling and deprotection using boron trifluoride etherate. Studies with Long-Evans rats were performed to establish safety, toxicity, and behavioral parameters. In addition, the Porsalt forced-swim test was used to demonstrate anti-depressant activity.
- Acerson, Mark J.,Fabick, Kimberly M.,Wong, Yong,Blake, Crystal,Lephart, Edwin D.,Andrus, Merritt B.
-
p. 2941 - 2944
(2013/06/27)
-
- Modular synthesis of amphiphilic Janus glycodendrimers and their self-assembly into glycodendrimersomes and other complex architectures with bioactivity to biomedically relevant lectins
-
The modular synthesis of 7 libraries containing 51 self-assembling amphiphilic Janus dendrimers with the monosaccharides d-mannose and d-galactose and the disaccharide d-lactose in their hydrophilic part is reported. These unprecedented sugar-containing dendrimers are named amphiphilic Janus glycodendrimers. Their self-assembly by simple injection of THF or ethanol solution into water or buffer and by hydration was analyzed by a combination of methods including dynamic light scattering, confocal microscopy, cryogenic transmission electron microscopy, Fourier transform analysis, and micropipet-aspiration experiments to assess mechanical properties. These libraries revealed a diversity of hard and soft assemblies, including unilamellar spherical, polygonal, and tubular vesicles denoted glycodendrimersomes, aggregates of Janus glycodendrimers and rodlike micelles named glycodendrimer aggregates and glycodendrimermicelles, cubosomes denoted glycodendrimercubosomes, and solid lamellae. These assemblies are stable over time in water and in buffer, exhibit narrow molecular-weight distribution, and display dimensions that are programmable by the concentration of the solution from which they are injected. This study elaborated the molecular principles leading to single-type soft glycodendrimersomes assembled from amphiphilic Janus glycodendrimers. The multivalency of glycodendrimersomes with different sizes and their ligand bioactivity were demonstrated by selective agglutination with a diversity of sugar-binding protein receptors such as the plant lectins concanavalin A and the highly toxic mistletoe Viscum album L. agglutinin, the bacterial lectin PA-IL from Pseudomonas aeruginosa, and, of special biomedical relevance, human adhesion/growth-regulatory galectin-3 and galectin-4. These results demonstrated the candidacy of glycodendrimersomes as new mimics of biological membranes with programmable glycan ligand presentations, as supramolecular lectin blockers, vaccines, and targeted delivery devices.
- Percec, Virgil,Leowanawat, Pawaret,Sun, Hao-Jan,Kulikov, Oleg,Nusbaum, Christopher D.,Tran, Tam M.,Bertin, Annabelle,Wilson, Daniela A.,Peterca, Mihai,Zhang, Shaodong,Kamat, Neha P.,Vargo, Kevin,Moock, Diana,Johnston, Eric D.,Hammer, Daniel A.,Pochan, Darrin J.,Chen, Yingchao,Chabre, Yoann M.,Shiao, Tze C.,Bergeron-Brlek, Milan,Andre, Sabine,Roy, Rene,Gabius, Hans-J.,Heiney, Paul A.
-
supporting information
p. 9055 - 9077
(2013/07/26)
-
- Two approaches to the aromatic core of the aminonaphthoquinone antibiotics
-
Two complementary approaches are presented for the synthesis of the quinone chromophores of the naphthoquinone ansamycins and related natural products. The first involves the use of an improved protocol for the manganese(III) acetate mediated cyclization of 5-aryl-1,3-dicarbonyl compounds to β-naphthols, leading to the simple, scalable preparation of building blocks suitable for the synthesis of naturally occurring aminonaphthoquinones. The second approach involves the Diels-Alder reaction of a series of new, ester-containing Danishefsky-type dienes with N-protected aminobenzoquinones to allow more expeditious access to similar intermediates.
- Nawrat, Christopher C.,Palmer, Leoni I.,Blake, Alexander J.,Moody, Christopher J.
-
p. 5587 - 5603
(2013/07/26)
-
- Synthetic studies towards stachybotrin C
-
The preparation of racemic des-hydroxy stachybotrin C is described. Different approaches have been studied. Observations made in the course of the synthesis show the efficiency of the intermolecular cyclization between the diethyl acetal 19 and phenol 12 leading to the benzopyran moiety 17. Georg Thieme Verlag KG · Stuttgart · New York.
- Tumma, Naresh,Jacolot, Maiwenn,Jean, Mickael,Chandrasekhar, Srivari,Van De Weghe, Pierre
-
supporting information
p. 2919 - 2922
(2013/02/22)
-
- Synthesis and antifungal properties of papulacandin derivatives
-
Derivatives of an antifungal agent that targets the β-(1,3)-D-glucan synthase, papulacandin D, were synthesized and tested for activity. The papulacandin D structure contains a challenging benzannulated spiroketal unit, which is introduced in a palladiumcatalyzed cross-coupling reaction of a glycal silanolate and an aryl iodide followed by an oxidative spiroketalization. Four different variants were made, differing in the nature of the acyl side chain with respect to the length, and in the number and stereochemistry of the double bonds. Moderate biological activity was observed for the derivatives with a side chain based on palmitic acid and linoleic acid.
- Van Der Kaaden, Marjolein,Breukink, Eefjan,Pieters, Roland J.
-
supporting information; experimental part
p. 732 - 737
(2012/07/14)
-
- PRENYLATED HYDROXYSTILBENES
-
Prenylated stilbene compounds and the use of such compounds in the treatment of diseases and medical disorders, for example cancer, skin ageing, inflammation, bacterial or fungal infection and immunosuppression.
- -
-
Page/Page column 33-34
(2012/11/14)
-
- Bright green luminescent molecular terbium plastic materials derived from 3,5-bis(perfluorobenzyloxy)benzoate
-
Luminescent lanthanide complexes (Eu3+ (1) or Tb3+ (2)) involving a highly fluorinated aromatic carboxylate, namely, 3,5-bis(perfluorobenzyloxy)benzoic acid which acts as an antenna chromophore and sensitizes the visible emitting lanthanides, have been synthesized and characterized and their photophysical properties investigated. The results demonstrated that the replacement of high-energy C-H vibrations with fluorinated phenyl groups in the 3,5-bis(benzyloxy)benzoate effectively improves the luminescence intensity and lifetimes of lanthanide complexes. It is interesting to note that the designed fluorinated carboxylate is well suited for the sensitization of Tb3+ emission (Φsen = 52%), thanks to a favorable position of the triplet state of the ligand as investigated in the Gd3+ complex. On the other hand, the corresponding Eu3+ complex shows weak luminescence efficiency (Φsen = 24%) due to poor match of the triplet state of the ligand with the emissive excited states of the metal ion. In the present work, efforts have also been made to isolate luminescent molecular terbium plastic materials by combining the unique optical properties of lanthanides with the mechanical characteristics, thermal stability, flexibility and film-forming tendency of polymers (PMMA). The photoluminescence quantum yields of polymer-lanthanide hybrid materials are significantly enhanced (53-65%) as compared to that of the Tb 3+-3,5-bis(perfluorobenzyloxy)benzoate complex. The Royal Society of Chemistry 2012.
- Sivakumar, Sarika,Reddy
-
experimental part
p. 10852 - 10859
(2012/08/07)
-
- Synthesis, electrochemistry and anticancer activity of novel ferrocenyl phenols prepared via azide-alkyne 1,3-cycloaddition reaction
-
A series of monophenols and diphenols containing the ferrocene-C triazolyl and ferrocene-Ntriazolyl bond were prepared in a cycloaddition reaction of ethynylferrocene with aryl and benzyl azides and in a reaction of azidoferrocene with phenylacetylenes, respectively. The anticancer activity of the prepared compounds against hormone-dependent (MCF-7) and hormone-independent (HCC38) breast cancer cell lines was studied. The investigated compounds exhibited moderate anticancer activity against hormone-independent (IC50 ~ 15-48 μM) cancer cell line and low activity against hormone-dependent cancer cell line (IC50 ~ 84-98 μM).
- Plazuk, Damian,Rychlik, B?azej,B?auz, Andrzej,Domaga?a, S?awomir
-
scheme or table
p. 102 - 112
(2012/09/07)
-
- Functionalization of pristine graphene with conjugated polymers through diradical addition and propagation
-
Hanging on: Pristine graphene was grafted with conjugated polymers through addition and propagation of diradicals generated from Bergman cyclization of enediyne-containing dendrimers. The surface functionalization was confirmed with TGA, FTIR and Raman spectroscopy, and AFM analysis. The sp2 network of graphene is only slightly destroyed, as revealed by conductivity measurements. Copyright
- Ma, Xiaowei,Li, Fei,Wang, Youfu,Hu, Aiguo
-
p. 2547 - 2550,4
(2020/09/02)
-
- Lanthanide-based coordination polymers assembled from derivatives of 3,5-dihydroxy benzoates: Syntheses, crystal structures, and photophysical properties
-
Two new aromatic carboxylic acids, namely, 3,5-bis(benzyloxy)- benzoic acid (HL1) and 3,5-bis(pyridine-2-ylmethoxy)benzoic acid (HL2), have been prepared by replacing the hydroxyl hydrogens of 3,5-dihydroxy benzoic acid with benzyl and pyridyl moieties, respectively. The anions derived fromHL1 and HL2 have been used for the support of a series of lanthanide coordination compounds [Eu 3+ = 1-2; Tb3+ = 3-4; Gd3+ = 5-6]. The new lanthanide complexes have been characterized on the basis of a variety of spectroscopic techniques in conjunction with an assessment of their photophysical properties. Lanthanide complexes 2, 4, and 6, which were synthesized from 3,5-bis(pyridine- 2-ylmethoxy)benzoic acid, were structurally authenticated by single-crystal X-ray diffraction. All three complexes were found to exist as infinite one-dimensional (1-D) coordination polymers with the general formula {[Ln(L2)3- (H2O)2] xH2O}n Scrutiny of the packing diagrams for 2, 4, and 6 revealed the existence of interesting two-dimensional molecular arrays held together by intermolecular hydrogen-bonding interactions. Furthermore, the coordinated benzoate ligands serve as efficient light harvesting chromophores. In the cases of 1-4, the lowest energy maxima fall in the range 280-340 nm [molar absorption coefficient (ε) = (0.39-1.01) × 104 M-1 cm-1]. Moreover, the Tb3+ complexes 3 and 4 exhibit bright green luminescence efficiencies in the solid state (φoverall = 60% for 3; 27% for 4) and possess longer excited state lifetimes than the other complexes (t = 1.16 ms for 3; 1.38 ms for 4). In contrast to the foregoing, the Eu3+ complexes 1 and 2 feature poor luminescence efficiencies.
- Sivakumar, Sarika,Reddy,Cowley, Alan H.,Butorac, Rachel R.
-
experimental part
p. 4882 - 4891
(2011/08/03)
-
- Total synthesis of (+)-papulacandin D
-
A total synthesis of (+)-papulacandin D has been achieved in 31 steps, in a 9.2% overall yield from commercially available materials. The synthetic strategy divided the molecule into two nearly equal sized subunits, the spirocyclic C-arylglycopyranoside and the polyunsaturated fatty acid side-chain. The C-arylglycopyranoside was prepared in 11 steps in a 30% overall yield from triacetoxyglucal. The fatty acid side-chain was also prepared in 11 steps in a 30% overall yield from geraniol. The key strategic transformations in the synthesis are: (1) a palladium-catalyzed, organosilanolate-based cross-coupling reaction of a dimethylglucal-silanol with an electron-rich and sterically hindered aromatic iodide and (2) a Lewis-base catalyzed, enantioselective allylation reaction of a dienal and allyltrichlorosilane. A critical element in the successful execution of the synthesis was the development of a suitable protecting group strategy that satisfied a number of stringent criteria.
- Denmark, Scott E.,Kobayashi, Tetsuya,Regens, Christopher S.
-
supporting information; experimental part
p. 4745 - 4759
(2010/08/06)
-
- PERYLENE TETRACARBOXIMIDE DERIVATIVES FOR PHOTOVOLTAIC DEVICES
-
The compounds of the present invention are represented by the following formula (I): wherein M is represented by the following formula: with R1, R2, R3, R4, R5, R6, R7, R8, R10, R11, X1, X2, X3, L, a, b, c, d, e, x, y, and z defined herein.
- -
-
Page/Page column 13
(2010/04/03)
-
- Synthesis of bifunctional hydroxamic acids as novel ligands for the hydrophilic stabilization of iron oxide nanoparticles
-
A general method for synthesizing bifunctional hydroxamic acids containing carboxylic acid or amino functionalities is reported. Various products from simple alkyl to complex dendrimer-like structures are described. Such molecules have recently been used in ligand-exchange reactions for the hydrophilic stabilization of originally oleic acid protected iron oxide nanoparticles. Georg Thieme Verlag Stuttgart · New York.
- Hofmann, Andreas,Graf, Christina,Kung, Shih-Hao,Kim, Myeongseob,Peng, Xiaogang,El-Aama, Randa,Ruehl, Eckart
-
experimental part
p. 1150 - 1158
(2010/06/13)
-
- A fluorinated dendritic TsDPEN-Ru(ii) catalyst for asymmetric transfer hydrogenation of prochiral ketones in aqueous media
-
The fluorinated dendritic chiral mono-N-tosylated 1,2- diphenylethlenediamine, FTsDPEN, has been synthesized and applied in the ruthenium(ii) complex-catalyzed asymmetric transfer hydrogenation of prochiral ketones in aqueous media.
- Wang, Weiwei,Wang, Quanrui
-
supporting information; experimental part
p. 4616 - 4618
(2010/10/21)
-
- Bismuth(III) triflate: A safe and easily handled precursor for triflic acid: Application to the esterification reaction
-
A series of carboxylic acids were converted into their corresponding methyl esters using bismuth(III) triflate as a catalyst in methanol. Good to excellent yields were obtained for different aliphatic or aromatic starting materials. In the reaction, bismuth triflate acts as a precursor that, upon hydrolysis, liberates sufficient triflic acid to catalyze the esterification.
- Kwie, Franciane Ho A.,Baudoin-Dehoux, Cecile,Blonski, Casimir,Lherbet, Christian
-
experimental part
p. 1082 - 1087
(2010/05/01)
-
- Modified approach for preparing (E)-Stilbenes related to resveratrol, and evaluation of their potential immunobiological effects
-
Resveratrol and closely related stilbenoids belong to the most intensively studied biologically active compounds. This interest evoked several attempts to prepare such compounds in a convenient synthetic way. Our approach allowed obtaining largely methoxystilbenes, formed as E-isomers only (using Wittig-Horner synthesis as the key step), which were further demethylated by boron tribromide. The hydroxymethoxystilbenes (e.g. pterostilbene) were prepared using isopropyl protection, later selectively deprotected by boron trichloride. The method is suitable for preparing such compounds in a large amount. Effects of the obtained stilbene derivatives on immunobiological responses triggered by lipopolysacharide and interferon-a were tested under in vitro conditions. Namely production of nitric oxide (NO) was investigated, and relation between the molecular structure and immunobiological activity was assessed.
- Smidrkal, Jan,Harmatha, Juraj,BudiSinsky, Milo,Vokae, Karel,ZIDEKc, Zdenik,Kmoniekova, Eva,Merkl, Roman,Filip, Vladimir
-
scheme or table
p. 175 - 186
(2010/07/10)
-
- Self-assembly and structural evolvement of polyoxometalate-anchored dendron complexes
-
A cationic dendritic molecule that has alkyl chains has been synthesized and employed to encapsulate anionic polyoxometalates through electrostatic interactions. The prepared surfactant-encapsulated polyoxometalate (SEP) complexes were used as building blocks to fabricate self-assemblies in solution and the solid state. Monodispersion, lamellar, and columnar assemblies of SEP complexes have been characterized in detail. With increasing the number of peripheral cationic dendrons on inorganic clusters, the SEPs undergo changes from globular assemblies to monodispersions in solution and from lamellar assemblies to hexagonal columnar structures in the solid state, depending on the amounts of cationic dendrons in the complexes. The structural evolvement was simulated through consideration of the size and shape of the cationic dendron and polyanionic clusters, and the experimental results are in good agreement with the interpretation of the simulations. The present research demonstrates a new kind of dendritic complex and provides a route for controlling their assembling states by simply alternating the number of cationic dendrons in the complexes.
- Yang, Yang,Wang, Yizhan,Li, Haolong,Li, Wen,Wu, Lixin
-
experimental part
p. 8062 - 8071
(2010/09/07)
-