Allylic C-H alkylation with a CF3-containing nucleophile
Allylic C-H alkylation of allylarenes with dimethyl 2- trifluoromethylmalonate was successfully developed. The reactions were carried out at room temperature in the presence of a catalytic amount of Pd(OAc) 2/Ph3P and a stoichiometric amount of 2,6- dimethylbenzoquinone. The reactions avoided defluorination successfully, providing a new method to construct a CF3-containing all-carbon quaternary center. The Royal Society of Chemistry 2013.
Li, Lun,Chen, Qing-Yun,Guo, Yong
supporting information
p. 8764 - 8766
(2013/09/24)
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