- Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles
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The dibromido analogue of cisplatin, cis-PtBr2(NH3)2 (cisPtBr2 hereafter), has been prepared and characterised. Its solution behaviour in standard phosphate buffer, at pH 7.4, was investigated spectrophotometrically and found to reproduce quite closely that of cisplatin; indeed, progressive sequential release of the two halide ligands typically occurs as in the case of cisplatin, with a roughly similar kinetics. Afterward, patterns of reactivity toward model proteins and standard ctDNA were explored and the nature of the resulting interactions elucidated. The antiproliferative properties were then evaluated in four representative cancer cell lines, namely A549 (human lung cancer), HCT116 (human colon cancer), IGROV-1 (human ovarian cancer) and FLG 29.1 (human acute myeloid leukaemia). Cytotoxic properties in line with those of cisplatin were highlighted. From these studies an overall chemical and biological profile emerges for cisPtBr2 closely matching that of cisplatin; the few slight, but meaningful differences that were underscored might be advantageously exploited for clinical application.
- Marzo, Tiziano,Bartoli, Gianluca,Gabbiani, Chiara,Pescitelli, Gennaro,Severi, Mirko,Pillozzi, Serena,Michelucci, Elena,Fiorini, Benedetta,Arcangeli, Annarosa,Quiroga, Adóracion G.,Messori, Luigi
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p. 535 - 542
(2016/06/13)
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- Reaction of platinum (II) and palladium (II) nitrite complexes with potassium bromide
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The reaction of nitrite-bridged binuclear platinum and palladium complexes and KBr in aqueous solution is studied. It is shown that the Pt-O-N bridging bond dissociates during the reaction to yield two mononuclear complexes. Rate constants of the reaction
- Gel'fman,Starkina,Salishcheva
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p. 1557 - 1560
(2008/10/09)
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- Cationic binuclear platinum(II) complexes with bromide bridges
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Binuclear platinum(II) complexes with bromide bridges were prepared by a reaction between platinum(II) diammine compounds.
- Salishcheva,Moldagulova,Gel'fman
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- Kinetics of the Displacement of Cyclobutane-1,1-dicarboxylate from Diammine(cycxlobutane-1,1-dicarboxylato)platinum(II) in Aqueous Solution
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The displacement of 1,1-cyclobutanedicarboxylate (cbdca2-) from has been studied in aqueous solution.In the presence of acid the process resembles the successive displacement of two monodentate carboxylates.The first (ring-opening) stage follows the rate law kobs = (k0 + k1K0+>)(1 + K0+>)-1, k0 = 8 x 1E-5 s-1, K0 = 0.6 dm3mol-1, k1 = 8.0 x 1E-4 s-1 at 25 deg C, while the second follows the simple relationship kobs = k+>, k = 1.61 x 1E-4 dm3mol-1s-1 at 25 deg C.In the absence of acid and other nucleophiles the complex is inert and in the presence of chloride the displacement of ligand follows a first-order dependence on ->, kobs = kCl = ->.At 80 deg C, kCl = 1.32 x 1E-4 dm3mol-1s-1.The chelate differs from the bis-monodentate carboxylate species in the great importance of the reverse, ring-closing process, which can be prevented in the presence of acid.
- Canovese, Luciano,Cattalini, Lucio,Chessa, Gavino,Tobe, Martin L.
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p. 2135 - 2140
(2007/10/02)
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