14591-91-4

Basic information

• Product Name: platinum(2+) bromide ammoniate (1:2:2)
• CAS NO: 14591-91-4
• Molecular Formula: Br₂H₆N₂Pt
• Molecular Weight: 388.953
• Mol File: 14591-91-4.mol
• Article Data: 5

Chemical Properties

• Vapor Pressure: 5990mmHg at 25°C
• CAS DataBase Reference: platinum(2+) bromide ammoniate (1:2:2)(CAS DataBase Reference)
• NIST Chemistry Reference: platinum(2+) bromide ammoniate (1:2:2)(14591-91-4)
• EPA Substance Registry System: platinum(2+) bromide ammoniate (1:2:2)(14591-91-4)

Safety Data

• Hazardous Substances Data: 14591-91-4(Hazardous Substances Data)

Upstream product

• 26035-31-4 transplatin 
• 7558-02-3 potassium bromide 
• 41575-87-5 trans-dinitrato-diammine-platinum(II) 
• 10035-10-6 hydrogen bromide 
• 12234-22-9 {PtBr4}*{PtBr2} 
• 21169-98-2 {Pt(HC2O4)2} 
• 41575-87-5 cis-diaminedinitroplatinum(II) 
• 15663-27-1 cisplatin 
• 63700-88-9 cisplatin 
• 16893-25-7 {Pt(2)Br2} 
• 41349-15-9 cis-diammineoxalatoplatinum(II) 
• 90670-30-7 cis-diamminebis(dimethyl sulfide)platinum(II) perchlorate 

Downstream Products

• 20115-65-5 {Pt}(2+) = trans-diaqua-diammine-platinum(II) (2+) = trans-Diaquo-diammin-platin(II) (2+) 
• 7440-06-4 platinum 
• 13455-12-4 platinum(II) bromde 
• 7664-41-7 ammonia 
• 110790-63-1 tetraphenylphosphonium amminetribromoplatinate(II) 

Relevant articles and documents

Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles

The dibromido analogue of cisplatin, cis-PtBr2(NH3)2 (cisPtBr2 hereafter), has been prepared and characterised. Its solution behaviour in standard phosphate buffer, at pH 7.4, was investigated spectrophotometrically and found to reproduce quite closely that of cisplatin; indeed, progressive sequential release of the two halide ligands typically occurs as in the case of cisplatin, with a roughly similar kinetics. Afterward, patterns of reactivity toward model proteins and standard ctDNA were explored and the nature of the resulting interactions elucidated. The antiproliferative properties were then evaluated in four representative cancer cell lines, namely A549 (human lung cancer), HCT116 (human colon cancer), IGROV-1 (human ovarian cancer) and FLG 29.1 (human acute myeloid leukaemia). Cytotoxic properties in line with those of cisplatin were highlighted. From these studies an overall chemical and biological profile emerges for cisPtBr2 closely matching that of cisplatin; the few slight, but meaningful differences that were underscored might be advantageously exploited for clinical application.

Cationic binuclear platinum(II) complexes with bromide bridges

Binuclear platinum(II) complexes with bromide bridges were prepared by a reaction between platinum(II) diammine compounds.

Reactivity of cis-diamminebis (dimethyl sulfide) platinum (II) perchlorate

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