145912-93-2

Basic information

• Product Name: 4-PYRIDIN-3-YLBUTANAL
• Synonyms: 4-PYRIDIN-3-YLBUTANAL;3-Pyridinebutanal(9CI)
• CAS NO: 145912-93-2
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Product Categories: PYRIDINE
• Mol File: 145912-93-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-PYRIDIN-3-YLBUTANAL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDIN-3-YLBUTANAL(145912-93-2)
• EPA Substance Registry System: 4-PYRIDIN-3-YLBUTANAL(145912-93-2)

Safety Data

• Hazardous Substances Data: 145912-93-2(Hazardous Substances Data)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 639089-30-8 3-(3-[1,3]-dioxolan-2-ylpropyl)pyridine 
• 138487-20-4 4-(pyridin-3-yl)-1-but-3-ynol 
• 79-37-8 oxalyl dichloride 
• 60753-14-2 3-(4-hydroxybutyl)-pyridine 
• 67-68-5 dimethyl sulfoxide 
• 109839-74-9 3-(3-bromopropyl)pyridine 
• 2859-67-8 3-(3-pyridyl)propan-1-ol 
• 174523-91-2 4-(3-pyridyl)butyl tert-butyldimethylsilyl ether 
• 639089-51-3 3-((E)-3-[1,3]Dioxolan-2-yl-propenyl)-pyridine 
• 188709-42-4 1-(1'',3''-dithianyl)-3-(3'-pyridyl)-propane 

Downstream Products

• 192715-08-5 2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylamino)-ethyl]-1H-indole-5-carboxylic acid ethyl ester 
• 192643-85-9 2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester 

Relevant articles and documents

Synthesis and antitumor activity of novel pyridinium fullerene derivatives

Purpose: We have previously reported that some cationic fullerene derivatives exhibited anticancer activity, and they are expected to be a potential lead compound for an anti-drug resistant cancer agent. However, they are bis-adducts and a mixture of multiple regioisomers, which cannot be readily separated due to the variability of substituent positions on the fullerene cage. To overcome this issue, we evaluated the antiproliferative activities of a set of mono-adduct derivatives and examined their structure-activity relationship. In addition, the in vivo antitumor activity of selected derivatives was also examined. Methods: Nineteen pyridinium fullerene derivatives were newly designed and synthesized in this study. Their antiproliferative activities were evaluated using several cancer cell lines including drug-resistant cells. Furthermore, in vivo antitumor activity of several derivatives was investigated in mouse xenograft model of human lung cancer. Results: The derivatives inhibited the proliferation of cancer cell lines, including cisplatin-resistant cells and doxorubicin-resistant cells. It was also shown that compound 10 (10 μM), 13 (10 μM) and cis-14 (10 μM) induced the intracellular oxidative stress. In addition, compound 13 (20 mg/kg) and cis-14 (15 mg/kg) significantly exhibited antitumor activity in mouse xenograft model of human lung cancer. Conclusion: We synthesized a novel set of mono-adduct fullerene derivatives functionalized with pyridinium groups and found that most of them show potent antiproliferative activities against cancer cell lines and some of them show significant antitumor activities in vivo. We propose that these fullerene derivatives serve as the lead compounds for a novel type of antitumor agents.

Identification of 4-(1H-Imidazol-4(5)-ylmethyl)pyridine (Immethridine) as a Novel, Potent, and Highly Selective Histamine H3 Receptor Agonist

In this study, the piperidine ring of immepip and its analogues was replaced by a rigid heterocyclic pyridine ring. Many compounds in the series exhibit high affinity and agonist activity at the human histamine H3 receptor. Particularly, the 4-

Synthesis and Structure-Activity Relationships of Conformationally Constrained Histamine H3 Receptor Agonists

Immepip, a conformationally constrained analogue of the histamine congener imbutamine, shows high affinity and functional activity on the human H 3 receptor. Using histamine and its homologues as prototypes, other rigid analogues containing eit

2-Aryl-2,2-difluoroacetamide FKBP12 Ligands: Synthesis and X-ray Structural Studies

2-Aryl-2,2-difluoroacetamido-proline and pipecolate esters are high affinity FKBP12 ligands whose rotamase inhibitory activity is comparable to that seen for the corresponding ketoamides. X-ray structural studies suggest that the fluorine atoms participat

Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists

A series of heterocyclic 2-(3,5-dimethylphenyl)tryptamine derivatives was prepared and evaluated on a rat gonadotropin releasing hormone receptor assay. The carbon tether length and heterocyclic ring attached to the amino group of 2-(3,5-dimethylphenyl)tr

Potent nonpeptide GnRH receptor antagonists derived from substituted indole-5-carboxamides and -acetamides bearing a pyridine side-chain terminus

A pyridine side-chain terminus has been incorporated into the indole-5-carboxamide and indole-5-acetamide series of GnRH antagonists. Potent activity was observed in binding and functional assays. Certain branched or cyclic tertiary amides were identified

Synthesis of the Cyclostellettamines A-F and Related Bis(3-alkylpyridinium) Macrocycles

A general method was developed for the synthesis of a variety of symmetric and asymmetric macrocyclic bispyridines. 3-Hydroxyalkylpyridines 18-20 were prepared, converted to the corresponding iodides and protected on the pyridine nitrogen with a p-methoxy

ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE

There are disclosed compounds of formula (I) STR1 and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.

Enantioselective synthesis of haminol-1, an alarm pheromone of a Mediterranean mollusc

The first enantioselective synthesis of (-)-(R)-haminol-1 is described in this paper. The chiral part of the molecule was prepared by reduction of an optically active β-ketosulfoxide. The all-trans trienic part was stereoselectively synthesized via reductive elimination of a 1,6-dibenzoate-2,4-diene with sodium amalgam.