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Boronic acid, (4-bromo-1-naphthalenyl)(9CI), is a chemical compound that belongs to the class of boronic acids and is a derivative of naphthalene, a polycyclic aromatic hydrocarbon. It possesses unique reactivity and structural features due to the bromo-substituent on the naphthalene ring, making it a potentially valuable building block for the synthesis of organic compounds and materials with specific functions and properties.

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  • 145965-14-6 Structure
  • Basic information

    1. Product Name: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI)
    2. Synonyms: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI);(4-Bromonaphthalen-1-yl)boronic acid;4-Bromo-1-naphthaleneboronic acid;4-Bromonaphthalene-1-boronic acid;4-broMo-1-naphthalenylboronic acid;1-BroMonaphthalene-4-boronic acid;B-(4-bromo-1-naphthalenyl)boronic acid;4-Bromo-1-naphthaleneboronic Acid (contains varying amounts of Anhydride)
    3. CAS NO:145965-14-6
    4. Molecular Formula: C10H8BBrO2
    5. Molecular Weight: 250.88432
    6. EINECS: N/A
    7. Product Categories: BORONICACID
    8. Mol File: 145965-14-6.mol
  • Chemical Properties

    1. Melting Point: 230-260 °C
    2. Boiling Point: 421.7±47.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: White to pale brown/Solid
    5. Density: 1.62±0.1 g/cm3 (20 ºC 760 Torr)
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    8. Solubility: soluble in Methanol
    9. PKA: 8.16±0.30(Predicted)
    10. CAS DataBase Reference: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI)(145965-14-6)
    12. EPA Substance Registry System: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI)(145965-14-6)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 36/37/38
    3. Safety Statements: 26
    4. WGK Germany: 3
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 145965-14-6(Hazardous Substances Data)

145965-14-6 Usage

Uses

Used in Organic Synthesis:
Boronic acid, (4-bromo-1-naphthalenyl)(9CI) is used as a reagent in Suzuki-Miyaura cross-coupling reactions, which are important processes in the formation of carbon-carbon bonds. Its unique reactivity and structural features contribute to the synthesis of organic compounds with specific functions and properties.
Used in Materials Science:
In the field of materials science, Boronic acid, (4-bromo-1-naphthalenyl)(9CI) may have specific applications due to its unique reactivity and structural features. It can be utilized in the development of materials with tailored properties for various applications, such as in electronics, pharmaceuticals, or other advanced technologies.
Used in Pharmaceutical Industry:
Boronic acid, (4-bromo-1-naphthalenyl)(9CI) can be employed as a building block in the synthesis of pharmaceutical compounds, potentially leading to the development of new drugs with improved therapeutic properties. Its unique structural features may enable the creation of molecules with enhanced binding affinity, selectivity, or other desirable characteristics.
Used in Chemical Research:
In the realm of chemical research, Boronic acid, (4-bromo-1-naphthalenyl)(9CI) serves as a valuable compound for studying the reactivity and properties of boronic acids and their derivatives. It can be used to explore new reaction mechanisms, develop novel synthetic methods, and gain insights into the fundamental chemistry of these important reagents.

Check Digit Verification of cas no

The CAS Registry Mumber 145965-14-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,9,6 and 5 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 145965-14:
(8*1)+(7*4)+(6*5)+(5*9)+(4*6)+(3*5)+(2*1)+(1*4)=156
156 % 10 = 6
So 145965-14-6 is a valid CAS Registry Number.

145965-14-6 Well-known Company Product Price

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  • (Code)Product description
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  • TCI America

  • (B4463)  4-Bromo-1-naphthaleneboronic Acid (contains varying amounts of Anhydride)  

  • 145965-14-6

  • 1g

  • 630.00CNY

  • Detail
  • Alfa Aesar

  • (H55625)  4-Bromonaphthalene-1-boronic acid, 97%   

  • 145965-14-6

  • 250mg

  • 217.0CNY

  • Detail
  • Alfa Aesar

  • (H55625)  4-Bromonaphthalene-1-boronic acid, 97%   

  • 145965-14-6

  • 1g

  • 608.0CNY

  • Detail
  • Alfa Aesar

  • (H55625)  4-Bromonaphthalene-1-boronic acid, 97%   

  • 145965-14-6

  • 5g

  • 2129.0CNY

  • Detail

145965-14-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-Bromonaphthalen-1-yl)boronic acid

1.2 Other means of identification

Product number -
Other names 4-BROMONAPHTHALENE-1-BORONIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:145965-14-6 SDS

145965-14-6Relevant articles and documents

Discovery of a flexible triazolylbutanoic acid as a highly potent uric acid transporter 1 (URAT1) inhibitor

Tian, He,Liu, Wei,Zhou, Zhixing,Shang, Qian,Liu, Yuqiang,Xie, Yafei,Liu, Changying,Xu, Weiren,Tang, Lida,Wang, Jianwu,Zhao, Guilong

, (2016)

In order to systematically explore and understand the structure-activity relationship (SAR) of a lesinurad-based hit (1c) derived from the replacement of the S atom in lesinurad with CH2, 18 compounds (1a-1r) were designed, synthesized and subjected to in vitro URAT1 inhibitory assay. The SAR exploration led to the discovery of a highly potent flexible URAT1 inhibitor, 1q, which was 31-fold more potent than parent lesinurad (IC50 = 0.23 μM against human URAT1 for 1q vs. 7.18 μM for lesinurad). The present study discovered a flexible molecular scaffold, as represented by 1q, which might serve as a promising prototype scaffold for further development of potent URAT1 inhibitors, and also demonstrated that the S atom in lesinurad was not indispensable for its URAT1 inhibitory activity.

DIAMINE COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME

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Paragraph 0465-0467, (2020/01/12)

Provided are a diamine compound and an organic light-emitting device including the same. The organic light-emitting device includes: a first electrode; a second electrode; and an organic layer between the first electrode and the second electrode and comprising an emission layer, the organic layer including a diamine compound represented by one selected from Formulae 1-1 to 1-8.

Organic light-emitting device including diamine compound and diamine compound

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Paragraph 0553-0557, (2020/01/08)

The present invention provide a diamine compound and an organic light-emitting device including the same. The organic light-emitting device includes: a first electrode; a second electrode; and an organic layer between the first electrode and the second electrode and comprising an emission layer, the organic layer including a diamine compound represented by one selected from Formulae 1-1 to 1-8.

Thiophene derivatives used as inhibitor of URAT1

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Paragraph 0133; 0135; 0136; 0137, (2019/04/26)

The invention relates to thiophene derivatives used as an inhibitor of urate transporter 1 (URAT1), in particular relates to the thiophene derivatives represented by a general formula (I) shown in thedescription, a pharmaceutically-acceptable salt of the thiophene derivatives, and preparation methods of the thiophene derivatives and the pharmaceutically-acceptable salt, and particularly relates to an application of the thiophene derivatives and the pharmaceutically-acceptable salt used as a therapeutic agent for a disease associated with an abnormal uric acid level.

Composite taken as URAT 1 inhibitor

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, (2018/05/16)

The invention provides a series of composite with a formula (I), wherein n is selected from 1, 2 or 3, X is selected from O or S, Q is selected from C or N, and R is selected from H, halogen or -C1-6.The composite can be used as the URAT 1 inhibitor and can be used for treating hyperuricemia and gout.

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