91-20-3

Basic information

• Product Name: Naphthalene
• Synonyms: 'LGC' (2402);'LGC' (2603);1-NAPHTHALENE;TAR CAMPHOR;NAPTHALENE;NAPTHALIN;NAPHTHENE;NAPHTHALENE
• CAS NO: 91-20-3
• Molecular Formula: C₁₀H₈
• Molecular Weight: 128.17052
• EINECS: 202-049-5
• Product Categories: Intermediates of Dyes and Pigments;Naphthalene;Organoborons;Highly Purified Reagents;Other Categories;Zone Refined Products;Analytical Chemistry;Standard Solution of Volatile Organic Compounds for Water & Soil Analysis;Standard Solutions (VOC);Chemistry;Naphthalenes;Analytical Standards;AromaticsVolatiles/ Semivolatiles;Volatiles/ Semivolatiles;Arenes;Building Blocks;Organic Building Blocks;Alpha Sort;Chemical Class;FumigantsVolatiles/ Semivolatiles;Hydrocarbons;Insecticides;N;NA - NIAnalytical Standards;NaphthalenesChemical Class;Neats;N-OAlphabetic;Pesticides;PAH
• Mol File: 91-20-3.mol
• Article Data: 991

Chemical Properties

• Melting Point: 80-82 °C(lit.)
• Boiling Point: 218 °C(lit.)
• Flash Point: 174 °F
• Appearance: White to almost white/Faint beige to brown to salmon red powder
• Density: 0.99
• Vapor Density: 4.4 (vs air)
• Vapor Pressure: 0.03 mm Hg ( 25 °C)
• Refractive Index: 1.5821
• Storage Temp.: APPROX 4°C
• Solubility: methanol: soluble50mg/mL, clear, colorless
• Explosive Limit: 0.9-5.9%(V)
• Water Solubility: 30 mg/L (25 ºC)
• Merck: 14,6370
• BRN: 1421310
• CAS DataBase Reference: Naphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: Naphthalene(91-20-3)
• EPA Substance Registry System: Naphthalene(91-20-3)

Safety Data

• Hazard Codes: Xn,N,F,T
• Statements: 22-40-50/53-67-65-38-11-39/23/24/25-23/24/25-52/53-20
• Safety Statements: 36/37-46-60-61-62-45-16-7-33-25-9
• RIDADR: UN 1334 4.1/PG 3
• WGK Germany: 3
• RTECS: QJ0525000
• TSCA: Yes
• HazardClass: 4.1
• PackingGroup: III
• Hazardous Substances Data: 91-20-3(Hazardous Substances Data)

Usage

description

Naphthalene is a white solid chemical that vaporizes easily. It has a strong smell. You can sometimes smell naphthalene in the air or in water. Called white tar and tar camphor, naphthalene is used in mothballs and moth flakes. Petroleum and coal contain naphthalene. Naphthalene, the simplest of the fused or condensed ring hydrocarbon compounds composed of two benzene rings sharing two adjacent carbon atoms. Naphthalene is the most abundant single constituent of coal tar, a volatile product from the destructive distillation of coal, and is also formed in modern processes for the high-temperature cracking (breaking up of large molecules) of petroleum. 1-Methylnaphthalene and 2-methylnaphthalene are naphthalene-related compounds. 1-Methylnaphthalene is a clear liquid and 2-methylnaphthalene is a solid; both can be smelled in air and in water at very low concentrations. 1-Methylnaphthalene and 2-methylnaphthalene are used to make other chemicals such as dyes and resins. 2-Methylnaphthalene is also used to make vitamin K.

Chemical Properties

Different sources of media describe the Chemical Properties of 91-20-3 differently. You can refer to the following data:
1. Naphthalene is a crystalline, white, flammable, polycyclic aromatic hydrocarbon consisting of two fused benzene rings. It has a pungent odor and sublimes readily above its melting point; it has been traditionally used in moth balls and is responsible for the moth balls characteristic odor. Naphthalene is a natural component of fossil fuels and is the single most abundant component of coal tar, accounting for approximately 11% of dry coal tar.
2. Naphthalene is a colorless to brown crystalline solid with a characteristic “moth ball” odor. It evaporates easily and has a strong odor of tar or mothballs. Solubility in water is low (31.7 mg/l at 25 °C), and it is soluble in benzene, alcohol, ether, and acetone (ATSDR, 2005). Shipped as a molten solid.

Uses

Different sources of media describe the Uses of 91-20-3 differently. You can refer to the following data:
1. In industry, naphthalene is used to manufacture a plastic called polyvinyl chloride (PVC). In public restrooms, naphthalene can be found in toilet deodorant blocks. At home, naphthalene can be found in moth repellents. Naphthalene balls are extensively used as household preservative of woolen clothes and as a deodorant tablet for the toilets, urinals, bathrooms etc. These are manufactured from naphthalene flakes by a tabletmaking machine having its ball shape die. Naphthalene is an important hydrocarbon raw material and is primarily used to manufacture phthalic anhydride and polyvinyl chloride (PVC) plastics, but is also used in moth repellents and toilet deodorant blocks. Naphthalene was used in liquid-phase exfoliation of graphite in organic solvents for the production of graphene sheets. It was used in preparation of carbon-coated Si 70 Sn 30 nanoparticles. It was used as fluorescent probe to study the aggregation behavior of sodium cholate. It was used to investigate influence of added short chain linear and branched alcohols on the binding of 1:1 complex of naphthalene and β-cyclodextrin.
2. In addition to oxidation and reduction reactions, naphthalene readily undergoes substitutionreactions such as nitration, halogenation, sulfonation, and acylation to produce a varietyof other substances, which are used in the manufacture of dyes, insecticides, organic solvents,and synthetic resins. The principal use of naphthalene is for the production of phthalic anhydride,C8H4O3. Naphthalene is catalytically oxidized to phthalic anhydride: 2C10H8 + 9O2 → 2C4H8O3 +4CO2 + 4H2O using metal oxide catalysts. Phthalic anhydride is used to produce plastics,phthalate plasticizers, insecticides, pharmaceuticals, and resins. Sulfonation of naphthalene withsulfuric acid produces naphthalenesulfonic acids, which are used to produce naphthalene sulfonates.Naphthalene sulfonates are used in various formulations as concrete additives, gypsumboard additives, dye intermediates, tanning agents, and polymeric dispersants. Naphthalene isused to produce carbamate insecticides such as carbaryl, which is a wide-spectrum, generalpurposeinsecticide.
3. Naphthalene occurs naturally in fossil fuels such as coal and petroleum. It is commonly produced from the distillation and fractionation of coal tar. Naphthalene is used as an intermediate in the production of phthalate plasticizers, other plastics and resins, and other products such as dyes, wood preservatives, explosives, lubricants, pharmaceuticals, deodorizers, and insect repellants. Moth balls and other moth repellants, and some solid block deodorizers used for toilets and diaper pails, are made of crystalline naphthalene (ATSDR, 2005).

Health Hazard

Different sources of media describe the Health Hazard of 91-20-3 differently. You can refer to the following data:
1. Most of the data available on the toxic effects of naphthalene have been derived from animal studies conducted either in vivo or with in vitro preparations. Rats and mice breathing naphthalene vapors daily for a lifetime had irritated noses and nose tumors and irritated lungs. Some female mice had lung tumors. Some animals got cloudy eyes after ingesting it. It is not clear if naphthalene causes reproductive problems in animals. Although there is no direct data showing that naphthalene can cause cancer in people, naphthalene exposure can lead to cancer in animals. Exposure to large amounts of naphthalene may damage or destroy red blood cells, a condition called hemolytic anemia. Symptoms of hemolytic anemia are feeling very tired or restless, lack of appetite, and pale skin. Exposure to large amounts of naphthalene may also cause upset stomach, diarrhea, blood in the urine,and yellow-colored skin. Very young children and unborn children are at higher risk if they are exposed to naphthalene, especially if they ingest the chemical. Some infants have become ill when they were close to clothing or blankets stored in naphthalene mothballs.
2. Inhalation of naphthalene vapor may causeirritation of the eyes, skin, and respiratorytract, and injury to the cornea. Other symptoms are headache, nausea, confusion, andexcitability. The routes of exposure of thiscompound into the body are inhalation, ingestion, and absorption through the skin; andthe organs that may be affected are the eyes,liver, kidney, blood, skin, and central nervoussystem.The most severe toxic effects from naphthalene, however, may come from oral intakeof large doses of this compound. In animals, as well as in humans, ingestion of largeamounts may cause acute hemolytic anemiaand hemoglobinuria attributed to its metabolites, 1- and 2-naphthol and naphthoquinones.Infants are more sensitive than adults becauseof their lower capacity for methemoglobinreduction. Other symptoms from ingestion ofnaphthalene are gastrointestinal pain and kidney damage. The LD50 values reported inthe literature show variation among differentspecies. In mice, an oral LD50 value may beon the order of 600 mg/kg. Symptoms of respiratory depression and ataxia were noted.Chronic exposure to naphthalene vapormay affect the eyes, causing opacities of thelens and optical neuritis. The acute effectsfrom inhalation of its vapors at high concentrations are nausea and vomiting.Inhalation studies have shown positivetumorigenic response in mice. Studies conducted under National Toxicology Program(NTP) show clear evidence of carcinogenicityin rats resulting from inhalation of naphthalene vapors (NTP 2000). Increased incidencesof respiratory epithelial adenoma and olfactory epithelial neuroblastoma in the nose wereobserved in both the sexes of rats. On thebasis of these findings IARC has reevaluatednaphthalene and reclassified it under Group2B carcinogen, as possibly carcinogenic tohumans (IARC 2002)..

Toxicity

Naphthalene is a white solid substance with a strong smell. Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. This can cause organ damage. In humans, naphthalene is broken down to alpha-naphthol, which is linked to the development of hemolytic anemia. Kidney and liver damage may also occur. Alpha-naphthol and other metabolites are excreted in urine. In animals, naphthalene breaks down into other compounds including alpha-naphthol, which may affect the lungs and eyes. Naphthalene was found in the milk of exposed cows, but the residues disappeared quickly after the cows were no longer exposed. Nearly all the naphthalene was broken down into other compounds and excreted in their urine.

Description

Naphthalene occurs as transparent prismatic plates also available as white scales, powder balls, or cakes with a characteristic mothball or strong coal tar and aromatic odour. It is sparingly soluble in water but soluble in methanol/ethanol and very soluble in ether. Naphthalene is a commercially important aromatic hydrocarbon. Naphthalene occurs as a white solid or powder. Naphthalene occurs in coal tar in large quantities and is easily isolated from this source in pure condition. It volatilises and sublimes at room temperature above the melting point. The primary use for naphthalene is in the production of phthalic anhydride, also of carbamate insecticides, surface active agents and resins, as a dye intermediate, as a synthetic tanning agent, as a moth repellent, and in miscellaneous organic chemicals. Naphthalene is used in the production of phthalic anhydride; it is also used in mothballs. Naphthalene is also used in the manufacture of phthalic and anthranilic acids to make indigo, indanthrene, and triphenyl methane dyes, for synthetic resins, lubricant, celluloid, lampblack, smokeless powder, and hydronaphthalenes. Naphthalene is also used in dusting powders, lavatory deodorant discs, wood preservatives, fungicide, and as an insecticide. It has been used as an intestinal antiseptic and vermicide and in the treatment of pediculosis and scabies.

History

In 1819, naphthalene was obtained as white crystals during the pyrolysis of coal tar by John Kidd (1775–1851), a British physician and chemist, and Alexander Garden (1757–1829), an American living in Britain. Kidd described the properties of the white crystals he obtained from coal tar and proposed the named naphthaline for the substance; naphthaline was derived from naphtha, a general term for a volatile, fl ammable, hydrocarbon liquid. Michael Faraday (1791–1867) determined the correct empirical formula for naphthalene in 1825, and Richard August Carl Emil Erlenmeyer (1825–1909) proposed the fused benzene ring structure in 1866.

Production Methods

Naphthalene is produced from coal tar or petroleum. It is made from petroleum by dealkylationof methylnaphthalenes in the presence of hydrogen at high temperature and pressure.Petroleum was a major source of naphthalene until the 1980s, but now most naphthaleneis produced from coal tar. The pyrolysis of bituminous coal produces coke and coke ovengases. Naphthalene is condensed by cooling the coke gas and then separated from the gas.

Definition

Different sources of media describe the Definition of 91-20-3 differently. You can refer to the following data:
1. naphthalene: A white volatilesolid, C10H8; r.d. 1.025;m.p. 80.55°C; b.p. 218°C. Naphthaleneis an aromatic hydrocarbon withan odour of mothballs and is obtainedfrom crude oil. It is a raw materialfor making certain syntheticresins.
2. ChEBI: An aromatic hydrocarbon comprising two fused benzene rings. It occurs in the essential oils of numerous plant species e.g. magnolia.

Synthesis Reference(s)

Journal of the American Chemical Society, 96, p. 3686, 1974 DOI: 10.1021/ja00818a072The Journal of Organic Chemistry, 54, p. 4474, 1989 DOI: 10.1021/jo00279a046Tetrahedron Letters, 27, p. 5541, 1986 DOI: 10.1016/S0040-4039(00)85262-4

General Description

Heterogeneous ozonolysis of naphthalene adsorbed on XAD-4 resin has been studied using annular denuder technique.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Vigorous reactions, sometimes amounting to explosions, can result from the contact between aromatic hydrocarbons, such as Naphthalene, and strong oxidizing agents. They can react exothermically with bases and with diazo compounds. Substitution at the benzene nucleus occurs by halogenation (acid catalyst), nitration, sulfonation, and the Friedel-Crafts reaction. Naphthalene, camphor, glycerol, or turpentine will react violently with chromic anhydride [Haz. Chem. Data 1967. p 68]. Friedel-Crafts acylation of Naphthalene using benzoyl chloride, catalyzed by AlCl3, must be conducted above the melting point of the mixture, or the reaction may be violent [Clar, E. et al., Tetrahedron, 1974, 30, 3296].

Hazard

Toxic by inhalation. Upper respiratory tract irritant, cataracts and hemolytic anemia. Possible carcinogen.

Fire Hazard

Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.

Flammability and Explosibility

Flammable

Safety Profile

Human poison by ingestion. Experimental poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An eye and skin irritant. Can cause nausea, headache, daphoresis, hematuria, fever, anemia, liver damage, vomiting, convulsions, and coma. Poisoning may occur by ingestion of large doses, inhalation, or skin absorption. Questionable carcinogen with experimental tumorigenic data. Flammable when exposed to heat or flame; reacts with oxidizing materials. Explosive reaction with dinitrogen pentaoxide. Reacts violently with CrOs, aluminum chloride + benzoyl chloride. Fires in the benzene scrubbers of coke oven gas plants have been attributed to oxidation of naphthalene. Explosive in the form of vapor or dust when exposed to heat or flame. To fight fire, use water, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

Naphthalene is used as a chemical intermediate or feedstock for synthesis of phthalic, anthranilic, hydroxyl (naphthols), amino (naphthylamines), and sulfonic compounds; which are used in the manufacture of various dyes and in the preparation of phthalic anhydride, 1-naphthyl-N-methyl carbonate; and β-naphthol. Naphthalene is also used in the manufacture of hydronaphthalenes, synthetic resins; lampblack, smokeless powder; and celluloid. Naphthalene has been used as a moth repellent. Approximately 100 million people worldwide have G6PD deficiency which would make them more susceptible to hemolytic anemia on exposure to naphthalene. At present, more than 80 variants of this enzyme deficiency have been identified. The incidence of this deficiency is 0.1% in American and European Caucasians, but can range as high as 20% in American blacks and greater than 50% in certain Jewish groups. Newborn infants have a similar sensitivity to the hemolytic effects of naphthalene, even without G6PD deficiency.

Carcinogenicity

Naphthalene is reasonably anticipated to be a human carcinogenbased on sufficient evidence from studies in experimental animals.

Shipping

UN1334 Naphthalene, crude or Naphthalene, refined, Hazard Class: 4.1; Labels: 4.1-Flammable solid. UN2304 (molten) Hazard Class: 4.1; Labels: 4.1-Flammable solid.

Purification Methods

Crystallise naphthalene once or more times from the following solvents: EtOH, MeOH, CCl4, *C6H6, glacial acetic acid, acetone or diethyl ether, followed by drying at 60o in an Abderhalden drying apparatus. It has also been purified by vacuum sublimation and by fractional crystallisation from its melt. Other purification procedures include refluxing in EtOH over Raney Ni and chromatography of a CCl4 solution on alumina with *benzene as eluting solvent. Baly and Tuck [J Chem Soc 1902 1908] purified naphthalene for spectroscopy by heating with conc H2SO4 and MnO2, followed by steam distillation (repeating the process), and formation of the picrate which, after recrystallisation (m 150o) is decomposed with base and the naphthalene is steam distilled. It is then crystallised from dilute EtOH. It can be dried over P2O5 under vacuum (take care not to make it sublime). Also purify it by sublimation and subsequent crystallisation from cyclohexane. Alternatively, it has been washed at 85o with 10% NaOH to remove phenols, with 50% NaOH to remove nitriles, with 10% H2SO4 to remove organic bases, and with 0.8g AlCl3 to remove thianaphthalenes and various alkyl derivatives. Then it is treated with 20% H2SO4, 15% Na2CO3 and finally distilled. [Gorman et al. J Am Chem Soc 107 4404 1985.] Zone refining purified naphthalene from anthracene, 2,4-dinitrophenylhydrazine, methyl violet, benzoic acid, methyl red, chrysene, pentacene and indoline. [Beilstein 5 IV 1640.]

Toxicity evaluation

Systemic absorption of naphthalene vapor may result in cataracts. The biochemical basis for naphthalene cataract has been investigated. Naphthalene is metabolized in the liver to 1,2-dihydro-1,2-dihydroxynaphthalene. Lenticular catechol reductase biotransforms 1,2-dihydro-1,2-dihydroxynaphthalene to 1,2-dihydroxynaphthalene, which, in turn, is auto-oxidized in air at neutral pH to 1,2-naphthoquinone and hydrogen peroxide. Ascorbic acid reverses the latter reaction and forms dehydroascorbic acid, which diffuses out of the lens very slowly. Dehydroascorbic acid has been shown to accumulate in the lens of rabbits that were fed naphthalene and lens incubated in vitro with 1,2-dihydro- 1,2-dihydroxynaphthalene. The sequence of reactions involves the reduction of ascorbic acid by 1,2-naphthoquinone in the aqueous humor to dehydroascorbic acid, which rapidly penetrates the lens and is reduced by glutathione. Oxidized glutathione and 1,2-naphthoquinone may compete for enzyme glutathione reductase, which normally maintains high reticular levels of reduced glutathione. A reduction in the concentration of these coupled with the removal of oxygen from the aqueous humor due to the autooxidation of 1,2-dihydroxynaphthalene may make the lens sensitive to naphthalene toxicity.

Incompatibilities

Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Violent reactions with chromium(III) oxide, dinitrogen pentoxide; chromic anhydride.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

InChI:InChI=1/C10H8/c1-2-6-10-8-4-3-7-9(10)5-1/h1-8H

Synthetic route

tetralin (119-64-2) → naphthalene (91-20-3)

Conditions	Yield
With triisobutylaluminum; Co acetylacetonate In neat (no solvent) at 150 - 200℃; Product distribution; other solvent, catalyst and reagent; turnover time and inhibition of reaction and catalyst;	100%
With 2,3-dicyano-5,6-dichloro-p-benzoquinone In benzene for 1.33333h; Reflux;	62%
With phenyl isocyanate; palladium on activated charcoal at 220℃; for 6h;	57%

5-(2-Naphthyloxy)-1-phenyl-1H-tetrazole (17743-32-7) → naphthalene (91-20-3)

Conditions	Yield
With ethanol; water; tetrabutylammonium hypophosphite; benzene; palladium on activated charcoal for 3h; Product distribution; hydrogenation in a biphasic solvent system, other H-donor, other time, different amounts of substrate or catalyst, addition of 18-crown-6-ether;	100%

3,5-dimethyl-1-phenyl-1H-pyrazole (1131-16-4) → naphthalene (91-20-3)

Conditions	Yield
at 920℃; under 0.7 Torr; for 1.66667E-05h; Mechanism; flash vacuum thermolysis;	100%

1-Methoxy-1.2-dihydronaphthalin (75896-23-0) → naphthalene (91-20-3)

Conditions	Yield
With silica gel	100%

2,3,6,7-tetrakis(trimethylsilyl)naphthalene (62131-91-3) → naphthalene (91-20-3)

Conditions	Yield
With trifluoroacetic acid In tetrachloromethane for 12h; Ambient temperature;	100%

3-benzotellurepine (135447-30-2) → naphthalene (91-20-3)

Conditions	Yield
for 72h; Product distribution; Ambient temperature; other tellurepines;	100%
In (2)H8-toluene at 40.3℃; Kinetics; Further Variations:; Temperatures;	100%

1-methoxy-1,4-dihydronaphthalene (75896-22-9) → naphthalene (91-20-3)

Conditions	Yield
With silica gel	100%

1-Chloronaphthalene (90-13-1) → naphthalene (91-20-3)

Conditions	Yield
With water; sodium iodide; nickel dichloride; zinc; sonication In N,N,N,N,N,N-hexamethylphosphoric triamide at 60℃; for 8h; Product distribution;	100%
With water; sodium iodide; nickel dichloride; zinc; sonication In N,N,N,N,N,N-hexamethylphosphoric triamide at 60℃; for 8h;	100%
With ammonium formate In water at 20℃; for 6h;	99%

triethylsilane (617-86-7) + (2RS,3RS,4RS,5RS,6RS,7RS)-3,6-dimesityl-3,6-bis<2,4,6-trisphenyl>-3,6-disilatetracyclo<6.4.02,4.05,7>dodeca-1(8),9,11-triene → naphthalene (91-20-3) + 2-<2,4,6-trisphenyl>-1,1,1-triethyl-2-mesityldisilane

Conditions	Yield
In (2)H8-toluene at 120℃; for 30h;	A n/a B 100%

Benzo[d]thiepine (264-14-2) → naphthalene (91-20-3)

Conditions	Yield
In (2)H8-toluene at 23℃; Kinetics; Further Variations:; Temperatures;	100%

7-Selena-benzocycloheptene → naphthalene (91-20-3)

Conditions	Yield
In (2)H8-toluene at 22.8℃; Kinetics; Further Variations:; Temperatures;	100%

7-Phenyl-7H-7-arsa-benzocycloheptene → naphthalene (91-20-3)

Conditions	Yield
In (2)H8-toluene at 22.3℃; Kinetics; Further Variations:; Temperatures;	100%

oxirane (75-21-8) + (naphthalene)Yb(THF)3 → naphthalene (91-20-3) + Butane-1,4-diol (110-63-4) + ytterbium hydroxide

Conditions	Yield
With hydrogen cation In tetrahydrofuran shaken for 10 min at room temp.; centrifuged, decanted, soln. contains naphthalene, pptn. hydrolysed in THF: butanediol detd. by GLC in the organic layer and a pptn. (Yb(OH)3);	A 83% B 100% C 75%

1,2,3,4-tetrahydronaphthalene-1,4-diacetate (79909-37-8) → naphthalene (91-20-3)

Conditions	Yield
at 80 - 180℃; under 40 Torr;	99.8%

1-Bromonaphthalene (90-11-9) → naphthalene (91-20-3)

Conditions	Yield
With lithium aluminium tetrahydride In 1,2-dimethoxyethane at 35℃; for 6h; ultrasonic acceleration of reduction;	99%
With 2,2'-azobis(isobutyronitrile); tert-butyl(2,6-dimethoxy-1-methylcyclohexa-2,5-dien-1-yl)dimethylsilane In hexane for 18h; Heating;	99%
With 2,2'-azobis(isobutyronitrile); tert-butyl(2,6-dimethoxy-1-methylcyclohexa-2,5-dien-1-yl)dimethylsilane In hexane for 18h; Heating;	99%

1-Fluoronaphthalene (321-38-0) → naphthalene (91-20-3)

Conditions	Yield
With palladium 10% on activated carbon In isopropyl alcohol at 100℃; for 12h; Inert atmosphere;	99%
With C32H46N2Ru; sodium carbonate; isopropyl alcohol at 70℃; for 96h; Inert atmosphere; Schlenk technique; Glovebox;	96%
With s-butylmagnesium chloride; bis(cyclopentadienyl)titanium dichloride In tetrahydrofuran at 50℃; for 12h; Product distribution / selectivity;	88%

1-Iodonaphthalene (90-14-2) → naphthalene (91-20-3)

Conditions	Yield
With lithium aluminium tetrahydride In 1,2-dimethoxyethane at 35℃; for 6h; ultrasonic acceleration of reduction;	99%
With formaldehyd; palladium diacetate; caesium carbonate In dimethyl sulfoxide at 80℃; for 12h; Kinetics; Reagent/catalyst;	99%
With tri-n-butyl-tin hydride In acetonitrile at 20℃; for 24h; Irradiation; Inert atmosphere;	97%

1-Methoxynaphthalene (2216-69-5) → naphthalene (91-20-3)

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel(0); (dimethoxy)methylsilane; tricyclohexylphosphine In toluene at 80℃; for 12h; Inert atmosphere;	99%
With bis(1,5-cyclooctadiene)nickel(0); 1,1,3,3-Tetramethyldisiloxane; tricyclohexylphosphine In toluene at 110℃; for 14h; Inert atmosphere;	77%
Multi-step reaction with 2 steps 1: NaBH4,m-dicyanobenzene / acetonitrile; H2O / 7 h / Irradiation 2: 100 percent / silica gel View Scheme

tri(naphthalen-1-yl)bismuth (33397-22-7) → naphthalene (91-20-3) + 1-benzoylnaphthalene (642-29-5) + bismuth(III) chloride (7787-60-2)

Conditions	Yield
With aluminium trichloride; benzoic acid In chloroform 5 h reflux, molar ratio Bi(1-C10H7)3:AlCl3:C6H5COOH = 1:1:1;	A 34% B 9.3% C 99%
With iron(III) chloride; benzoic acid In chloroform 5 h reflux, molar ratio Bi(1-C10H7)3:FeCl3:C6H5COOH = 1:1:1;	A 44% B 10.2% C 96%

2-Methoxynaphthalene (93-04-9) → naphthalene (91-20-3)

Conditions	Yield
With triethylsilane; bis(1,5-cyclooctadiene)nickel (0); tricyclohexylphosphine In toluene at 110℃; for 14h; Reagent/catalyst; Concentration; Solvent;	99%
With isopropylmagnesium bromide; nickel diacetate; 1,3-dicyclohexyl-1H-imidazol-3-ium chloride In tetrahydrofuran at 100℃; for 18h; Inert atmosphere; Sealed tube;	70%
With bis(1,5-cyclooctadiene)nickel (0); sodium formate; 1,3-dicyclohexyl-1H-imidazol-3-ium chloride; sodium t-butanolate In toluene at 140℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique;	63%

tri(naphthalen-1-yl)bismuth (33397-22-7) → naphthalene (91-20-3) + bismuth(III) chloride (7787-60-2)

Conditions	Yield
With benzoic acid In chloroform molar ratio Bi(1-C10H7)3:C6H5COOH = 1:1;	A 49.1% B 98.4%
With AlCl3 or FeCl3 In chloroform reflux;	A 36-46 B >97

1-naphthyl triflate (99747-74-7) → naphthalene (91-20-3)

Conditions	Yield
With formic acid; triethylamine; palladium diacetate; triphenylphosphine In N,N-dimethyl-formamide at 65℃; for 12h;	98%
With triethylammonium formate; palladium diacetate; 1,3-bis-(diphenylphosphino)propane In N,N-dimethyl-formamide at 18℃; for 0.8h; Product distribution; other catalysts, variation of temperature;	92%
With lithium; nickel dichloride In tetrahydrofuran for 4h; Reduction; Heating;	21%
Multi-step reaction with 3 steps 1.1: iron(II) acetate; N,N,N,N,-tetramethylethylenediamine; sodium t-butanolate; bis(pinacol)diborane / di-isopropyl ether / 120 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C 2.2: 20 °C 3.1: C66H60BFeO2P4; N,N,N,N,-tetramethylethylenediamine; sodium t-butanolate / di-isopropyl ether; hexane; tetrahydrofuran / 15 h / 120 °C / Schlenk technique; Glovebox View Scheme

trans-4-deuterio-1,4-dihydro-1-methoxynaphthalene (101916-87-4) → naphthalene (91-20-3) + 1-deuteronaphthalene (875-62-7)

Conditions	Yield
With lithium diisopropyl amide In hexane for 0.5h; Product distribution; other solvents, bases;	A 2% B 98%

acetophenone (98-86-2) + 1-Chloronaphthalene (90-13-1) → naphthalene (91-20-3) + 2-(naphthalen-1-yl)-1-phenylethan-1-one (16216-08-3)

Conditions	Yield
With sodium amalgam; potassium tert-butylate; ammonia for 2h;	A n/a B 98%

(naphthalene)Yb2(THF)3(NaCl)3 → ytterbium(III) oxide + naphthalene (91-20-3) + sodium chloride (7647-14-5)

Conditions	Yield
With air In tetrahydrofuran stirred for 18 h under dry air; centrifuged, washed with benzene and water (Yb2O3), naphthalene detd. by GLC in the organic layer, aq. soln. contains NaCl;	A 98% B 98% C 96%

(naphthalene)Yb2(THF)3(NaCl)3 → ytterbium(III) oxide + naphthalene (91-20-3)

Conditions	Yield
With oxygen In tetrahydrofuran 18 h at room temp.;	A 96% B 98%

(1S,4S,5S,8S)-tetrabromo-1,2,3,4,5,6,7,8-octahydronaphthalene → naphthalene (91-20-3)

Conditions	Yield
at 150℃; for 120h; Aromatisation;	97%

1-naphthalenecarboxylic acid (86-55-5) → naphthalene (91-20-3)

Conditions	Yield
With triethylsilane; palladium diacetate; 2,2-dimethylpropanoic anhydride; 1,4-di(diphenylphosphino)-butane In toluene at 160℃; for 15h; chemoselective reaction;	97%
With water; palladium on activated charcoal at 250℃; under 30002.4 - 37503 Torr; for 14h;	74%
With methanol at 40℃; for 48h; Schlenk technique; Irradiation; Inert atmosphere;	70%

β-naphthaldehyde (66-99-9) → naphthalene (91-20-3)

Conditions	Yield
With palladium nanoparticles supported on fibrous silica In cyclohexane at 130℃; for 20h; Molecular sieve;	97%
With palladium diacetate In cyclohexane at 140℃; for 24h; Molecular sieve; air;	82%
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; triphenylphosphine In 1,4-dioxane at 110℃; for 48h; Inert atmosphere;	95 %Chromat.

2-naphthyl pivalate (1503-86-2) → naphthalene (91-20-3)

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); sodium formate; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 140℃; for 24h; Temperature; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique;	97%
With bis(1,5-cyclooctadiene)nickel(0); 1,1,3,3-Tetramethyldisiloxane; tricyclohexylphosphine In toluene at 110℃; for 10h; Inert atmosphere;	81 %Chromat.
With bis(1,5-cyclooctadiene)nickel(0); (dimethoxy)methylsilane; tricyclohexylphosphine In toluene at 80℃; for 12h; Inert atmosphere;	99 %Chromat.
Multi-step reaction with 2 steps 1: toluene / 90 °C / Inert atmosphere; Schlenk technique 2: sodium formate / toluene / 24 h / 120 °C / Inert atmosphere; Schlenk technique View Scheme

naphthalene (91-20-3) → phthalic anhydride (85-44-9)

Conditions	Yield
With oxygen	100%
With oxygen	100%
With oxygen	100%

naphthalene (91-20-3) → phthalic anhydride (85-44-9) + [1,4]naphthoquinone (130-15-4)

Conditions	Yield
With oxygen at 340 - 360℃; Product distribution / selectivity;	A 100% B 0.05%
With oxygen at 340 - 360℃;	A 100% B 0.1%
With oxygen at 340 - 360℃;	A 100% B 0.02%

naphthalene (91-20-3) → tetralin (119-64-2)

Conditions	Yield
With sodium; tert-butyl alcohol In tetrahydrofuran for 15h; Heating;	100%
With Raney nickel; isopropyl alcohol at 82℃; for 1h; Temperature; Inert atmosphere;	99%
With cobalt(II) chloride hexahydrate; lithium In tetrahydrofuran at 25℃; for 3h; Birch reaction; Inert atmosphere;	98%

naphthalene (91-20-3) → decalin (91-17-8)

Conditions	Yield
With Ti8O8(14+)*6C8H4O4(2-)*4O(2-)*3.3Li(1+)*0.7Co(2+)*0.7C4H8O*0.7H(1-); hydrogen In neat (no solvent) at 120℃; under 37503.8 Torr; for 18h;	100%
With hydrogen In cyclohexane at 100℃; under 33603.4 Torr; for 1h; Catalytic behavior; Temperature; Autoclave;	99%
With nickel(II) oxide; hydrogen; palladium In hexane at 150℃; under 37503.8 Torr; for 36h;	93%

naphthalene (91-20-3) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-1-(naphthalen-2-yl)propan-1-one (22422-70-4)

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 20℃; Cooling with ice;	100%
With carbon disulfide; aluminium trichloride
With aluminium trichloride In nitrobenzene 1.) 5 h, room temp., 2.) 30 min, 40-45 deg C;
Stage #1: naphthalene; 2-chloropropionyl chloride With aluminum (III) chloride In nitrobenzene at 0℃; Stage #2: With hydrogenchloride In nitrobenzene

naphthalene (91-20-3) + tetranitromethane (509-14-8) → 1-Nitro-4-trinitromethyl-1,4-dihydro-naphthalene (146850-06-8)

Conditions	Yield
In dichloromethane at 23℃; for 24h;	100%

naphthalene (91-20-3) + ethyl 2-chloro-2-methylthio-acetate (145628-18-8, 56078-31-0) → ethyl α-methylthio-1-naphthaleneacetate (75286-85-0)

Conditions	Yield
tin(IV) chloride In dichloromethane for 0.666667h; Ambient temperature;	100%
tin(IV) chloride In dichloromethane for 0.666667h; Ambient temperature; Yield given;

naphthalene (91-20-3) → (1R,2S)-1,2-dihydronaphthalene-1,2-diol (51268-88-3)

Conditions	Yield
With toluene dioxygenase; oxygen Enzymatic reaction; regioselective reaction;	100%
With toluene dioxygenase from Pseudomonas putida F1 variant A223V In ethanol at 30℃; for 0.5h; Enzymatic reaction; enantioselective reaction;	62.7%
Pseudomonas putida UV4;

naphthalene (91-20-3) + 1,3-Dimethyl-6-chlorouracil (6972-27-6) → 6-methoxy-1,3-dimethyluracil (4097-20-5)

Conditions	Yield
In methanol at 20℃; for 1h; UV-irradiation;	100%

naphthalene (91-20-3) + (Cp*Ru)2(μ-NHPh)(μ-hydride)(μ-η2:η2-C7H8) → [(Cp*Ru)2(μ-NHPh)(μ-H)(μ-η2:η2-naphthalene)]

Conditions	Yield
In tetrahydrofuran at 20℃; for 1h; Schlenk technique; Inert atmosphere;	100%

diazoacetic acid ethyl ester (623-73-4) + naphthalene (91-20-3) → exo-ethyl 2,3-benzo-2,4-norcaradiene-7-carboxylate

Conditions	Yield
With Ag3(μ2-(3,5-(CF3)2PyrPy))3 In dichloromethane at 20℃; Buchner Ring Enlargement;	100%

diazoacetic acid ethyl ester (623-73-4) + naphthalene (91-20-3) → ethyl 1a,7b-dihydro-1H-cyclopropa[a]naphthalene-1-carboxylate (13612-37-8)

Conditions	Yield
With chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate In 1,2-dichloro-ethane at 60℃; for 24h; Inert atmosphere;	99%
With copper(II) sulfate at 150℃; for 4h;	20%
at 140 - 145℃;
With rhodium (II) octanoate dimer In 1,2-dichloro-ethane at 25℃; for 0.333333h;	55 %Spectr.

naphthalene (91-20-3) → 1-Nitronaphthalene (86-57-7)

Conditions	Yield
With bismuth(III) nitrate; Montmorillonite KSF for 0.166667h; Nitration;	99%
With benzyltriphenylphosphonium nitrate; Methanesulfonic anhydride at 20℃; for 0.333333h;	99%
With In(OSO2CF3)3; nitric acid at 20 - 60℃; for 24h;	98%

naphthalene (91-20-3) + acetyl chloride (75-36-5) → 1'-naphthacetophenone (941-98-0) + methyl 2-naphthyl ketone (93-08-3)

Conditions	Yield
aluminium trichloride In 1,2-dichloro-ethane at 0℃; Rate constant; Kinetics; Mechanism; other temperature; other concentrations;	A 99% B 1%
aluminium trichloride In 1,2-dichloro-ethane at 0℃; Thermodynamic data; ΔH<*>(activation); Σ<*>(activation);	A 99% B 1%
With aluminium trichloride; 1-ethyl-3-methyl-1H-imidazol-3-ium chloride at 0℃; for 1h;	A 89% B 2%

Upstream product

• 75-21-8 oxirane 
• 119-64-2 tetralin 
• 75-44-5 phosgene 
• 60-29-7 diethyl ether 
• 580-13-2 2-bromonaphthalene 
• 941-98-0 1'-naphthacetophenone 
• 1125-78-6 5,6,7,8-Tetrahydro-2-naphthol 
• 642-29-5 1-benzoylnaphthalene 
• 90-15-3 α-naphthol 
• 527-84-4 2-methylisopropylbenzene 
• 447-53-0 1,2-Dihydronaphthalene 
• 4551-51-3 cis-hydrindane 
• 16939-57-4 (E)-buta-1,3-dienylbenzene 
• 4780-79-4 1-naphthalene methanol 

Downstream Products

• 85-47-2 1-naphthalenesulfonic acid 
• 42372-45-2 1-(2-naphthyl)-1-phenyl ethane 
• 4653-13-8 4-(1-naphthyl)-4-oxobutanoic acid 
• 1590-22-3 4-(2-naphthyl)-4-oxobutyric acid 
• 93-08-3 methyl 2-naphthyl ketone 
• 941-98-0 1'-naphthacetophenone 
• 132104-09-7 6-[1]naphthyl-6-oxo-hexanoic acid 
• 132104-10-0 6-(naphthalen-2-yl)-6-oxohexanoic acid 
• 4832-38-6 naphthalene; compound with 1,3-dinitro-benzene 
• 624724-80-7 N-(naphthalen-1-yl)-1-phenylmethanesulfonamide 
• 38119-03-8 2-[2]naphthoyl-benzoic acid 
• 5018-87-1 2-(naphthalene-1-carbonyl)-benzoic acid 
• 860539-07-7 1-(naphthalen-1-yl)-2,2-diphenylethan-1-one 
• 1787-27-5 naphthalene-1,3,5-trinitrobenzene complex 

Relevant articles and documents

The role of matrix material and CCl4 (electron acceptor) on the ionization mechanisms of matrix-isolated naphthalene

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From Esters to Ketones via a Photoredox-Assisted Reductive Acyl Cross-Coupling Strategy

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Cross-Coupling Reactions of Aryl Halides with Primary and Secondary Aliphatic Alcohols Catalyzed by an O,N,N-Coordinated Nickel Complex

A synthesis of alkyl aryl ethers was achieved via the cross-coupling of aryl halides with primary and secondary aliphatic alcohols catalyzed by a bench-stable nickel complex supported by a monoanionic O,N,N-tridentate ligand. This nickel-catalyzed reaction proceeds smoothly in the absence of a phosphine ligand, affording alkyl aryl ethers in moderate to good yields. (Figure presented.).