146140-95-6

Basic information

• Product Name: 2-(TERT-BUTYLCARBONYLAMINO)PHENYLBORONIC ACID
• Synonyms: 2-(PIVALOYLAMINO)PHENYLBORONIC ACID;2-(TERT-BUTYLCARBONYLAMINO)PHENYLBORONIC ACID;2-[(2,2-DIMETHYLPROPANOYL)AMINO]PHENYLBORONIC ACID;2-(2,2-DIMETHYL-PROPIONYLAMINO)PHENYLBORONIC ACID;AKOS BRN-0489;2-(Pivaloylamino)benzeneboronic acid;2-(2,2,2-Trimethylacetamido)benzeneboronic acid, 95%;2-(2,2-DIMETHYL-1-OXOPROPYL)AMINO PHENYL BORONIC ACID
• CAS NO: 146140-95-6
• Molecular Formula: C₁₁H₁₆BNO₃
• Molecular Weight: 221.06
• Product Categories: Heterocyclic Compounds;Aromatics;Boron Derivatives;Intermediates
• Mol File: 146140-95-6.mol

Chemical Properties

• Melting Point: 268-271℃
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.13g/cm³
• Refractive Index: 1.532
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Methanol
• PKA: 8.52±0.53(Predicted)
• CAS DataBase Reference: 2-(TERT-BUTYLCARBONYLAMINO)PHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TERT-BUTYLCARBONYLAMINO)PHENYLBORONIC ACID(146140-95-6)
• EPA Substance Registry System: 2-(TERT-BUTYLCARBONYLAMINO)PHENYLBORONIC ACID(146140-95-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 146140-95-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(TERT-BUTYLCARBONYLAMINO)PHENYLBORONIC ACID is used as a synthetic intermediate for the production of Norharmane, a compound with potential applications in the treatment of various medical conditions. Its role in the synthesis process is essential for creating effective pharmaceuticals.
Used in Chemical Research:
As a key component in the synthesis of DNA intercalating agents, 2-(TERT-BUTYLCARBONYLAMINO)PHENYLBORONIC ACID is used as a research tool in the field of chemistry. These agents have the ability to bind between the base pairs of DNA, which can be useful in studying the structure and function of DNA, as well as in the development of new drugs targeting DNA-related processes.
Used in Material Science:
The compound's chemical properties make it a valuable asset in material science, where it can be used to develop new materials with specific properties. Its role as a synthetic intermediate allows for the creation of novel materials with potential applications in various industries, such as electronics, aerospace, and automotive.

InChI:InChI=1/C11H16BNO3/c1-11(2,3)10(14)13-9-7-5-4-6-8(9)12(15)16/h4-7,15-16H,1-3H3,(H,13,14)

Upstream product

• 62-53-3 aniline 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 52732-22-6 isopropoxyboronic acid 
• 65854-92-4 N-(2-bromophenyl)-2,2-dimethylpropanamide 
• 121-43-7 Trimethyl borate 
• 6625-74-7 N-pivaloylaniline 

Downstream Products

• 172795-87-8 2,2-dimethyl-N-(2-(8-methoxy-7-quinolyl)phenyl)propanamide 
• 197524-27-9 2,2-Dimethyl-N-(2-quinolin-3-yl-phenyl)-propionamide 
• 250593-13-6 N-pyvaloyl-2-(2'-anilino)-3-bromoquinoline 
• 340699-67-4 2,2-dimethyl-N-(2-(2-methyl-3-pyridyl)phenyl)propanamide 
• 334709-45-4 2,2-dimethyl-N-(2-(4-chloro-3-fluoroquinol-2-yl)phenyl)propanamide 
• 518050-98-1 N-[2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)phenyl]pivalamide 
• 1312448-06-8 N,N'-bistosyl-2,2''-diamino-[1,1';3',1'']terphenyl 
• 1312447-89-4 5,7-ditosyl-5,7-dihydroindolo[2,3-b]carbazole 
• 172795-91-4 2,2-dimethyl-N-(2-(8-methoxy-5-phenyl-7-quinolyl)phenyl)propanamide 
• 170959-66-7 2,2-dimethyl-N-(2-(7,8-dimethoxy-5-quinolinyl)phenyl)propanamide 
• 170959-64-5 2,2-dimethyl-N-(2-(7-bromo-8-methoxy-5-quinolinyl)phenyl)propanamide 
• 170959-68-9 2,2-dimethyl-N-(2-(8-methoxy-5-quinolyl)phenyl)propanamide 
• 153035-11-1 2,2-Dimethyl-N-(2-(3-fluoro-4-methyl-2-pyridyl)phenyl)propanamide 
• 179676-88-1 2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide 

Relevant articles and documents

Pd-catalyzed sequential C-C and C-N bond formations for the synthesis of N-heterocycles: Exploiting protecting group-directed C-H activation under modified reaction conditions

Easy & efficient: A Pd-catalyzed domino olefination/conjugate addition reaction of N-Ts-2-arylanilines with activated olefins has been achieved at ambient temperature under the newly defined reaction conditions. This process highlighted the directing effect of the N-protecting group in C-H activation, displayed broad substrate scope with wide functional group compatibility; thus rendering a straightforward entry to a wide variety of N-heterocycles such as dihydrophenanthridines.

Pd-catalyzed intramolecular oxidative C-H amination: Synthesis of carbazoles

A Pd-catalyzed oxidative C-H amination of N-Ts-2-arylanilines under ambient temperature using Oxone as an inexpensive, safe, and easy-to-handle oxidant has been developed. This process represents a green and practical method for the facile construction of carbazoles with a broad substrate scope and wide functional group tolerance.

SOLID FORMS OF 1-ETHYL-3-(5-(5-FLUOROPYRIDIN-3-YL)-7-(PYRIMIDIN-2-YL)-1H-BENZO[D]IMIDAZOL-2-YL)UREA

Solid forms of crystalline1-ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)- 1H-benzo[d]imidazol-2-yl)urea, compositions containing solid forms of crystalline 1- ethyl-3-(5-(5-fluoropyridin-3-yl)-7-(pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)urea and m

PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS

The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of bacterial gyrase and Topoisomerase IV (Topo IV).

Synthesis of new flat polyheterocyclic systems potential DNA intercalating agents diazines part 47

Using a regioselective metallation in connection with Stille cross-coupling reaction, we report here an original synthetic route to obtain in few steps various flat tetra- or pentaheterocyclic compounds which could be potential intercalating DNA agents.