- Method for synthesizing quinoxaline compound under visible light induced iron catalysis condition
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The invention belongs to the technical field of compound synthesis, and particularly relates to a method for synthesizing quinoxaline compounds under visible light induced iron catalysis conditions. The method comprises the following steps: by taking non-activated aliphatic amine and o-phenylenediamine as raw materials, under the action of a photosensitizer, under the illumination of visible light, reacting in a solvent at room temperature and under oxygen conditions to generate the quinoxaline compound. The method has better substrate universality and relatively mild reaction conditions, not only realizes synthesis of the quinoxaline compound for the first time, but also widens the field of organic synthesis.
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Paragraph 0277-0281
(2021/07/10)
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- Hydrogen Auto-transfer Synthesis of Quinoxalines from o-Nitroanilines and Biomass-based Diols Catalyzed by MOF-derived N,P Co-doped Cobalt Catalysts
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A Co-based heterogeneous catalyst supported on N,P co-doped porous carbon (Co@NCP) is prepared via a facile in-situ doping-carbonization method. The Co@NCP composite features a large surface area, high pore volume, high-density and strong basic sites. Furthermore, doping of P atoms can regulate the electronic density of Co. Therefore, Co@NCP exhibits good performance for the synthesis of quinoxalines from o-nitroanilines and biomass-derived diols under alkali-free conditions.
- Sun, Kangkang,Li, Dandan,Lu, Guo-Ping,Cai, Chun
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p. 373 - 381
(2020/12/09)
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- ANDROGEN RECEPTOR ANTAGONISTS
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Compounds that inhibit the androgen receptor, pharmaceutical compositions comprising one or more of the compounds, as well as methods of treating cancer using such compounds are described.
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Paragraph 0366
(2019/08/26)
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- Synthesis of quinoxalines or quinolin-8-amines from N-propargyl aniline derivatives employing tin and indium chlorides
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Pyrazino compounds such as quinoxalines are 1,4-diazines with widespread occurrence in nature. Quinolin-8-amines are isomerically related and valuable scaffolds in organic synthesis. Herein, we present intramolecular main group metal Lewis acid catalyzed formal hydroamination as well as hydroarylation methodology using mono-propargylated aromatic ortho-diamines. The annulations can be conducted utilizing equal aerobic conditions with either stannic chloride or indium(iii) chloride and represent primary examples for main group metal catalyzed 6-exo-dig and 6-endo-dig, respectively, cyclizations in such settings. Both types of reactions can also be utilized in a one-pot manner starting from ortho-nitro N-propargyl anilines using stoichiometric amounts SnCl2·2H2O or In powder. Mechanistic considerations are presented regarding the substituent-depending regioselectivity.
- Aichhorn, Stefan,Himmelsbach, Markus,Sch?fberger, Wolfgang
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p. 9373 - 9380
(2015/09/15)
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- Convenient Synthesis of 4-Methoxy-3-nitro-1,2-benzenediamine and its Conversion into 6-Methoxy-5-nitroquinoxalines
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4-Methoxy-3-nitro-1,2-benzenediamine (6) has been prepared through nitration of 5-methoxy-2,1,3-benzoselenadiazole, followed by reductive removal of the selenium.Cyclocondensation of 6 with α-dicarbonyl compounds afforded the title quinoxalines, some of them novel and not easily obtainable by direct nitration.Methyl- or phenylglyoxal gave mixtures of quinoxalines in proportions strongly influenced by the acidity of the reaction medium.
- Grivas, Spiros,Tian, Wei
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p. 1109 - 1113
(2007/10/02)
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