- Synthesis method for 3-aminomethyl tetrahydrofuran
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The invention provides a synthetic method for 3-aminomethyl tetrahydrofuran. A target product, namely the 3-aminomethyl tetrahydrofuran is prepared by taking 2,5-dihydrofuran as an initial raw material. In the whole synthesis process, the synthesis method has the advantages of green and environmentally-friendly used raw materials, mild and conveniently-controllable reaction conditions, safe production, low risk, simple process, high yield, and more applicability to industrial production.
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Paragraph 0054; 0057; 0061; 0064; 0066; 0069; 0071; 0074
(2020/07/14)
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- Preparation method of 3-aminomethyltetrahydrofuran serving as dinotefuran intermediate
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The invention relates to a preparation method of 3-aminomethyltetrahydrofuran serving as a dinotefuran intermediate. Specifically, the preparation method comprises the steps: firstly, carrying out a condensation reaction on cyanoacetate serving as a raw material and 1,2-dihaloethane to obtain 2-haloethyl-2-cyanoacetate serving as an intermediate; next, further carrying out reduction to obtain 2-haloethyl-2-cyanoethanol serving as an intermediate; then, cyclizing 2-haloethyl-2-cyanoethanol serving as the intermediate to obtain 3-cyanotetrahydrofuran serving as an intermediate; and finally, catalytically hydrogenating 3-cyanotetrahydrofuran to obtain 3-aminomethyltetrahydrofuran serving as the dinotefuran intermediate. The preparation method disclosed by the invention is available in raw material, simple in operation and relatively low in production cost so as to be suitable for industrialized mass production.
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Paragraph 0044; 0046; 0049
(2018/07/07)
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- Preparation method of 3-aminomethyl tetrahydrofuran
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The invention relates to a preparation method of 3-aminomethyl tetrahydrofuran. Specifically the invention relates to a method of preparing 3-aminomethyl tetrahydrofuran through reducing 3-cyanotetrahydrofuran. A novel synthesis technology is adopted; gamma-butyrolactone and a halogen simple substance X2 are taken as the raw materials to prepare 3-X-gamma-butyrolactone; then 3-X-gamma-butyrolactone is reduced by a reducing agent to obtain 2-X-1,4-butylene glycol; 2-X-1,4-butylene glycol is dehydrated by a dehydrating agent to obtain 3-X tetrahydrofuran; 3-X tetrahydrofuran is converted into 3-cyanotetrahydrofuran in the presence of a cyaniding catalyst, and finally 3-cyanotetrahydrofuran is converted into 3-aminomethyl tetrahydrofuran in the presence of a hydrogenation catalyst. The synthesis technology has the advantages of easily available raw materials, simple operation, mild reaction conditions, high yield and product purity, little environmental pollution, and low production cost, is suitable for industrial massive production, and has a wide application prospect.
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Paragraph 0022; 0032-0034
(2017/07/12)
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- Synthesis method of tetrahydrofuran-3-methylamine
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The invention discloses a synthesis method of tetrahydrofuran-3-methylamine. The problems that the synthesis of the tetrahydrofuran-3-methylamine has the disadvantages of fussy route process, higher cost and harsh reaction condition in the prior art are solved. The synthesis method comprises the following steps of (1), in an organic solvent I, making acrylonitrile and epoxy ethane react to generate 3-cyano-tetrahydrofuran in a condition that a catalyst A exists; (2), purifying the 3-cyano-tetrahydrofuran, and then reducing the purified 3-cyano-tetrahydrofuran to obtain tetrahydrofuran-3-methylamine in conditions of an organic solvent II and a catalyst B. By using the synthesis method, the process flow and the production period are greatly shortened; raw materials are easily obtained; the synthesis method is green and environment-friendly, is low in cost, is simple to operate, is high in yield, and has obvious socioeconomic benefit and commercial application value.
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Paragraph 0014; 0029
(2017/09/01)
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- Preparation method for 3-aminomethyltetrahydrofuran
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The invention discloses a preparation method for 3-aminomethyltetrahydrofuran. The preparation method comprises the following steps: with acrylonitrile as a starting material, carrying out an addition reaction with 2-halogenated ethyl alcohol so as to obtain an intermediate 2-haloethyl-2-nitrile ethyl ether; then subjecting the intermediate 2-haloethyl-2-nitrile ethyl ether to cyclic condensation so as to obtain an intermediate 3-nitrile tetrahydrofuran; and finally subjecting the intermediate 3-nitrile tetrahydrofuran to catalytic hydrogenation so as to obtain 3-aminomethyltetrahydrofuran. The preparation method provided by the invention has the advantages of cheap and easily-available starting material, short synthetic route, simple process operation, low production cost, little pollution to the human body and the environment, good yield and applicability to large-scale industrial production.
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Paragraph 0013; 0022; 0023
(2017/02/24)
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- HIV Integrase Inhibitors
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The invention encompasses a series pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pha
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Page/Page column 10
(2009/01/20)
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- METHOD FOR PRODUCING 3-AMINOMETHYLTETRAHYDROFURAN DERIVATIVE
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An object of the present invention is to provide a process for producing a 3-cyanotetrahydrofuran derivative in a high yield from inexpensive industrial materials. According to the present invention, a 3-aminomethyltetrahydrofuran derivative is produced by preparing a 3-cyanotetrahydrofuran derivative in a high yield from an inexpensive and industrially easily available malic acid derivative, and reducing the cyano group of the 3-cyanotetrahydrofuran derivative.
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- METHOD FOR PRODUCING 3-AMINOMETHYLTETRAHYDROFURAN DERIVATIVE
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Disclosed is a method for highly efficiently producing a 3-aminomethyltetrahydrofuran derivative from a low-cost industrial raw material. Specifically, a 3-cyanotetrahydrofuran derivative is produced at high yield from a low-cost, industrially easily-available malic acid derivative, and then a 3-aminomethyltetrahydrofuran derivative is produced by reducing the cyano group of the 3-cyanotetrahydrofuran derivative.
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Page/Page column 30
(2008/06/13)
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- Method for producing organic compounds by substituting halogen atoms
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The invention pertains to a method in which a halogen atom of an organic compound is replaced with a group derived from a nucleophilic agent, at high yield and high efficiency, by the following method which includes a step of reacting the nucleophilic agent with an organic material having a halogen atom bonded to a carbon atom having four σ bonds, more specifically: a method for producing an organic compound having Q, the method including a step of reacting a compound represented by general formula (2) with an organic starting material having at least one halogen atom bonded to a carbon atom having four σ bonds so as to replace the halogen atom in the organic starting material with Q:MQa (wherein M represents an alkali metal atom, an alkali earth metal atom, or a rare earth metal atom; Q represents a moiety of an inorganic acid or an active hydrogen compound derived by eliminating a proton, wherein Q is a halogen atom different from the halogen atom in the organic starting material having the halogen atom bonded to the carbon atom having the four σ bonds; and a represents an integer of 1 to 3) in the presence of a compound represented by general formula (1) (wherein Z- represents an anion derived by eliminating a proton from an inorganic acid or an active hydrogen compound; R2 is the same or different; R2 each independently represent a C1-C10 hydrocarbon group or two R2 on the same nitrogen atom may be bonded with each other to form a ring with the nitrogen atom).
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