146335-23-1

Basic information

• Product Name: 5-CYANO-1,3-DIHYDROXYMETHYLBENZENE
• Synonyms: 5-CYANO-1,3-DIHYDROXYMETHYLBENZENE;3,5-bis(hydroxymethyl)Benzonitrile
• CAS NO: 146335-23-1
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17326
• Mol File: 146335-23-1.mol

Chemical Properties

• Boiling Point: 372.9±32.0 °C(Predicted)
• Appearance: /
• Density: 1.27±0.1 g/cm3(Predicted)
• PKA: 13.91±0.10(Predicted)
• CAS DataBase Reference: 5-CYANO-1,3-DIHYDROXYMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANO-1,3-DIHYDROXYMETHYLBENZENE(146335-23-1)
• EPA Substance Registry System: 5-CYANO-1,3-DIHYDROXYMETHYLBENZENE(146335-23-1)

Safety Data

• Hazardous Substances Data: 146335-23-1(Hazardous Substances Data)

Upstream product

• 773837-37-9 sodium cyanide 
• 71176-54-0 (3-amino-5-hydroxymethylphenyl)methanol 
• 99-27-4 dimethyl 5-aminoisophthalate 
• 10560-13-1 diethyl 5-nitro-isophthalate 
• 42122-73-6 diethyl 5-aminoisophthalate 
• 99-31-0 5-aminoisophthalic acid 
• 618-88-2 5-nitrobenzene-1,3-dicarboxylic acid 

Downstream Products

• 146335-24-2 (3-Aminomethyl-5-methyl-phenyl)-methanol 
• 77113-64-5 (Z)-3-(3,5-Bis-hydroxymethyl-phenyl)-2-methoxymethyl-acrylonitrile 
• 77113-54-3 [3-(2,4-Diamino-pyrimidin-5-ylmethyl)-5-hydroxymethyl-phenyl]-methanol 
• 188257-52-5 N-(dipivaloylfluoresceinyl)-N'-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzyl thiourea 
• 188257-55-8 N-biotinyl-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine 
• 171082-07-8 N-fluorenylmethyloxycarbonyl-3-(4,4'-dimethoxytrityloxymethyl)-5-(hydroxymethyl)benzylamine 
• 188257-47-8 (3-(aminomethyl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)phenyl)methanol 
• 171082-06-7 3-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(hydroxymethyl)benzonitrile 

Relevant articles and documents

THERAPEUTIC METHODS

The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.

METHODS FOR TREATING HEPATITIS B INFECTIONS

Certain embodiments of the invention provide a method for identifying a patient that has a higher likelihood of responding to an HBV antigen inhibitor, such a method comprising detecting a hepatitis B virus (HBV) infected patient's genotype at one or more of the IL28B/A associated SNPs described herein, wherein the relevant genotype(s) described herein are indicative of a patient that has a higher likelihood of responding to an HBV antigen inhibitor as compared to an HBV infected patient having different genotypes at these locations.

TARGETED COMPOSITIONS

The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS

The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Synthesis of achiral linker reagents for direct labelling of oligonucleotides on solid supports

Full experimental procedures for the synthesis of a series of new functional linker reagents (14-16) and solid supports (11-13) are reported. The achiral linker reagents and supports can be used for high yield incorporation of free amino groups, fluorescein or biotin into DNA oligomers.