- COMBINATION THERAPIES FOR TREATMENT OF MYELODYSPLASTIC SYNDROME
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The present invention relates to methods for treatment of myelodysplastic syndrome (MDS) by administration of a hypomethylating agent (HMA), such as azacitidine or decitabine, or a prodrug of either of the foregoing, or a pharmaceutically acceptable salt of any of the foregoing, and alvocidib, or a prodrug thereof, or a pharmaceutically acceptable salt of the foregoing.
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Paragraph 00626-00627; 00631
(2021/06/11)
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- CDK9 INHIBITORS AND POLYMORPHS THEREOF FOR USE AS AGENTS FOR TREATMENT OF CANCER
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A crystalline form and/or polymorph of a compound having the following structure (I), including tautomeric and zwitterionic forms thereof, are provided: Methods associated with preparation and use of the polymorphs, and pharmaceutical compositions comprising the same are also provided. Also provided are methods for preparing a compound having formula (I), or a salt, tautomer or zwitterionic form thereof.
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Paragraph 00346; 00369; 00370
(2020/07/05)
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- METHODS FOR TREATING CASTRATION-RESISTANT AND CASTRATION- SENSITIVE PROSTATE CANCER
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Methods of treating castration-resistant and castrati on- sensitive prostate cancer using a compound having the following structure (I): or a pharmaceutically acceptable salt or zwitterionic form thereof, are provided.
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Page/Page column 86-87
(2020/07/05)
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