REACTION OF KETENE DITHIOACETALS WITH THIOAMIDES. A SYNTHESIS OF PYRIMIDINE DERIVATIVES
Reaction of ketene dithioacetals with thioamides gave 5-cyano-2-methyl(or phenyl)-6-methylthio-4-thioxopyrimidines.
Lorente, Antonio,Garcia, M. Luisa,Fernandez, Misericordia,Soto, Jose L.
p. 1573 - 1582
(2007/10/02)
One-pot Stereoselective Synthesis and Structural Study of 1-Methylthio-2-azabuta-1,3-diene-4-carbonitriles
The methylation of the carbanion resulting from addition of thioamides to methoxymethylene compounds 1 or ketene dithioacetals 2 affords two series of 1-methylthio-2-azabuta-1,3-diene-4-carbonitriles 5 or 6.The IR, MS and 1H and 13C NMR spectral propertie