146651-24-3 Usage
Explanation
The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 8 carbon (C), 9 hydrogen (H), 1 iodine (I), and 2 oxygen (O) atoms.
Explanation
This is an alternative name for the compound, which provides a more detailed description of its structure. The "cis" prefix indicates the arrangement of the chemical groups on the same side of the dioxane ring.
Explanation
The compound's structure consists of a 1,3-dioxane ring (a six-membered ring with two oxygen atoms), an iodine atom attached to the 5-position, and a phenyl group (a six-membered ring with alternating single and double carbon-carbon bonds) attached to the 2-position in a cis configuration.
Explanation
Organic compounds are primarily made up of carbon and hydrogen atoms, and this compound is no exception.
Explanation
Due to its unique structure and reactivity, this compound is used as a starting material or intermediate in the synthesis of various pharmaceutical and agrochemical products.
Explanation
The compound's unique structure and reactivity make it a promising candidate for use in the development of new drugs and pharmaceuticals.
Explanation
The cis configuration refers to the arrangement of the chemical groups on the same side of the dioxane ring, which can influence the compound's properties and reactivity.
Explanation
The 9CI (Chemical Abstracts Service Registry Number) is a unique identifier assigned to a specific chemical compound, which helps in its identification and classification.
Chemical Structure
1,3-Dioxane ring with an attached iodine atom and a phenyl group in the cis configuration
Type of Compound
Organic compound
Application
Building block in the synthesis of pharmaceutical and agrochemical compounds
Potential Applications
Medicinal chemistry and drug development
Configuration
cis
Registry Number
9CI
Check Digit Verification of cas no
The CAS Registry Mumber 146651-24-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,6,5 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146651-24:
(8*1)+(7*4)+(6*6)+(5*6)+(4*5)+(3*1)+(2*2)+(1*4)=133
133 % 10 = 3
So 146651-24-3 is a valid CAS Registry Number.
146651-24-3Relevant articles and documents
Copper-Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon–Iodine Bonds
Cai, Aijie,Liu, Wei,Wang, Chao,Yan, Wenhao
supporting information, p. 27070 - 27077 (2021/11/18)
The engagement of unactivated alkyl halides in copper-catalyzed cross-coupling reactions has been historically challenging, due to their low reduction potential and the slow oxidative addition of copper(I) catalysts. In this work, we report a novel strategy that leverages the halogen abstraction ability of aryl radicals, thereby engaging a diverse range of alkyl iodides in copper-catalyzed Negishi-type cross-coupling reactions at room temperature. Specifically, aryl radicals generated via copper catalysis efficiently initiate the cleavage of the carbon–iodide bonds of alkyl iodides. The alkyl radicals thus generated enter the copper catalytic cycles to couple with a difluoromethyl zinc reagent, thus furnishing the alkyl difluoromethane products. This unprecedented Negishi-type difluoromethylation approach has been applied to the late-stage modification of densely functionalized pharmaceutical agents and natural products.
