1708-40-3Relevant articles and documents
Stereoselective synthesis of substituted 5-hydroxy-1,3-dioxanes
Forbes, David C.,Ene, Doina G.,Doyle, Michael P.
, p. 879 - 882 (1998)
A series of 5-hydroxy-1,3-dioxanes has been synthesized using a practical three-step strategy beginning with acetal/ketal formation of tris(hydroxymethyl)aminomethane followed by oxidative cleavage of the amino alcohol. After the ketone was revealed, stereoselective reduction with common hydride reagents, LiAlH4 for the trans isomers and L-Selectride for the cis analogues, gave the target compounds in high yield.
Biodegradable poly(ethylene glycol)-poly(?-carprolactone) polymeric micelles with different tailored topological amphiphilies for doxorubicin (DOX) drug delivery
Chen,Zhang,Wu,Peng,Su,Cao,He,Li
, p. 58160 - 58172 (2016)
Three poly(ethylene glycol)-poly(?-carprolactone) (PEG-PCL) copolymers with different topologies but identical molar ratio between PEG to PCL were designed. These copolymers, namely, diblock (L-PEG-PCL), triblock (B-PEG-PCL), and star shaped (S-PEG-PCL) copolymers, were extensively characterized by 1H Nuclear Magnetic Resonance (1H NMR), Fourier Transform Infrared Spectroscopy (FTIR), and Gel Permeation Chromatography (GPC) analyses. The effect of topology on crystallization was investigated by X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC). Results showed that the diblock copolymer possessed the highest crystallinity, followed by triblock and star shaped copolymers. Although the topology did not affect the self-assembly behavior of copolymers, the effects on size, size distribution, drug loading content, and drug release rate of the polymeric micelles were observed. The micelles self-assembled from linear diblock copolymer achieved higher cellular uptake and lower half maximal inhibitory concentration (IC50). These findings are favorable to establish the foundation to further design proper structure of amphiphilic copolymers as nanocarrier systems for efficient anticancer therapy.
Occurrence of a novel cannabimimetic molecule 2-sciadonoylglycerol (2- eicosa-5',11',14'-trienoylglycerol) in the umbrella pine Sciadopitys verticillata seeds
Nakane, Shinji,Tanaka, Tamotsu,Satouchi, Kiyoshi,Kobayashi, Yuriko,Waku, Keizo,Sugiura, Takayuki
, p. 758 - 761 (2000)
The umbrella pine Sciadopitys verticillata seeds were found to contain a substantial amount (16.7 nmol/g) of sciadonic acid (all-cis-5,11,14- eicosatrienoic acid)-containing 2-monoacylglycerol, i.e., 2- sciadonoylglycerol (2-eicosa-5',11',14'-trienoylglycerol). Because the structure of 2-sciadonoylglycerol closely resembles that of 2- arachidonoylglycerol, the endogenous natural ligand for the cannabinoid receptor, we examined whether or not 2-sciadonoylglycerol exhibits cannabimimetic activity using NG108-15 neuroblastoma x glioma hybrid cells which express the cannabinoid CB1 receptor. We found that 2- sciadonoylglycerol induces rapid transient elevation of intracellular free Ca2+ concentration in NG108-15 cells through a cannabinoid CB1 receptor- dependent mechanism similar to the case of 2-arachidonoylglycerol, yet the activity of 2-sciadonoylglycerol was apparently lower than that of 2- arachidonoylglycerol. The activity of 2-sciadonoylglycerol was detectable from 3-10 nM, reaching a maximum at around 10 μM. To our knowledge, this is the first report showing the occurrence of a cannabimimetic monoacylglycerol in higher plants.
Preparation method of glycerol formal
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Paragraph 0051-0058, (2021/07/21)
The invention discloses a preparation method of benzaldehyde glycerol acetal. The method adopts a solid catalyst composed of phosphomolybdic acid anions and polymeric ionic liquid cations to catalyzethe reaction of benzaldehyde and glycerol, and due to the fine adjustment of acid-base sites, the yield of benzaldehyde glycerol acetal prepared through the method reaches 95%, and meanwhile, the six-membered ring acetal has specific selectivity.
Structure–Activity Relationships of WOx-Promoted TiO2–ZrO2 Solid Acid Catalyst for Acetalization and Ketalization of Glycerol towards Biofuel Additives
Baithy, Mallesham,Mukherjee, Deboshree,Rangaswamy, Agolu,Reddy, Benjaram M.
, (2021/07/25)
Abstract: WOx-promoted TiO2–ZrO2 solid acid catalyst was prepared and applied in the catalytic acetalization and ketalization of glycerol with carbonyl compounds to produce biofuel additives. The presence of WOx promoter and TiO2 remarkably improved the catalytic activity of ZrO2. Approximately, 100% glycerol conversion was evidenced with non-bulky aliphatic aldehydes and ketones like, propanol and cyclohexanone. The physical characterization of WOx-promoted TiO2–ZrO2, revealed a higher formation of tetragonal crystalline phase of ZrO2, over monoclinic. The total surface acidity and the ratio of Br?nsted to Lewis acidic site concentrations were determined by NH3-TPD and pyridine-chemisorbed FTIR spectroscopy, respectively. A considerably higher concentration of Lewis acidic sites, ~ 213.29?μmol/gm, was evidenced on the WOx-promoted TiO2–ZrO2 catalyst surface. Catalytic activity study revealed a direct correlation between the surface Lewis acidic site concentration and the activity of catalyst. This significant observation indicated the key role of Lewis acidic sites in this catalytic process. The WOx-promoted TiO2–ZrO2 catalyst was also considerably stable and showed good performance in the acetalization/ketalization of glycerol with other substituted carbonyl compounds. Graphic Abstract: The WOx-promoted TiO2–ZrO2 solid acid catalyst exhibits superior catalytic performance for acetalization and ketalization of glycerol with carbonyl compounds to produce biofuel additives. [Figure not available: see fulltext.].
