- SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION
-
Compounds of the formula wherein R1, R1', R2, R2' R4, R5, R6 and R7 are as described herein; as well as pharmaceutically acceptable prodrugs or salts of acidic compounds of formula I with bases and or basic compounds of formula I with acids are antiprolif
- -
-
-
- Substituted pyrroles
-
Compounds of the formula STR1 wherein R 1 and R 1'' are independently alkyl, aryl, alkenyl or alkynyl;R 2 and R 2'' are independently hydrogen or alkyl;R 4, R 5, R 6 and R 7 each independently are STR2 CH 2 OR 10, CHO, CH 2 NR 11 R 12, hydrogen, halogen,
- -
-
-
- Convenient preparation of N-substituted indoles by modified Leimgruber-Batcho indole synthesis
-
A modified reductive alkylation of pre-indole 3, prepared from readily available Leimgruber-Batcho indole synthesis derived intermediates, followed by acidic methanolysis generates 6-carbomethoxy-N-substituted indoles. The three step preparation of pre-indole 3 from substituted 2-nitrotoluene 1 in 66% yield and conversion to a variety of N-substituted indoles is presented.
- Coe, Jotham W.,Vetelino, Michael G.,Bradlee, Michael J.
-
p. 6045 - 6048
(2007/10/03)
-
- Palladium-Catalyzed Synthesis of Indoles from 2-Nitrostyrenes
-
In the presence of palladium salts, oxidation of 2-nitrostyrenes 1 with nitrous acid alkyl esters 2 resulted in the formation of 2-nitrophenylacetaldehyde dialkyl acetals 3.Reductive cyclization of the acetals 3 with iron powder in acetic acid afforded indoles 5 in good yield.
- Izumi, Taeko,Soutome, Michihiko,Miura, Takashi
-
p. 1625 - 1629
(2007/10/02)
-