146667-95-0

Upstream product

• 67-56-1 methanol 
• 104447-80-5 (E)-1-(dimethylamino)-2-[4-(methoxycarbonyl)-2-nitrophenyl]ethene 
• 133831-27-3 methyl 4-(2-(dimethylamino)vinyl)-3-nitrobenzoate 
• 96-98-0 4-methyl-3-nitrobenzoic acid 
• 624-91-9 methyl nitrite 
• 126759-36-2 methyl 4-ethenyl-3-nitrobenzoate 

Downstream Products

• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 1204-32-6 methyl 1-methylindole-6-carboxylate 
• 182345-23-9 3-(1-Benzyl-piperidin-4-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester 
• 1071216-81-3 3-(1-Benzyl-pyrrolidin-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester 
• 182345-25-1 3-(1-Aza-bicyclo[2.2.2]oct-3-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester 
• 182345-22-8 3-(1-Butyl-piperidin-4-ylamino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester 
• 182345-24-0 4-(2,2-Dimethoxy-ethyl)-3-(1-ethyl-piperidin-3-ylamino)-benzoic acid methyl ester 
• 182345-21-7 4-(2,2-Dimethoxy-ethyl)-3-(1-methyl-piperidin-4-ylamino)-benzoic acid methyl ester 
• 1027993-17-4 3-(Cyclohexylmethyl-amino)-4-(2,2-dimethoxy-ethyl)-benzoic acid methyl ester 
• 1025901-98-7 4-(2,2-Dimethoxy-ethyl)-3-(1-ethyl-propylamino)-benzoic acid methyl ester 
• 167478-76-4 2-amino-4-carbomethoxy-phenylacetaldehyde dimethylacetal 

Relevant academic research and scientific papers

SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION

Compounds of the formula wherein R1, R1', R2, R2' R4, R5, R6 and R7 are as described herein; as well as pharmaceutically acceptable prodrugs or salts of acidic compounds of formula I with bases and or basic compounds of formula I with acids are antiprolif

Substituted pyrroles

Compounds of the formula STR1 wherein R 1 and R 1'' are independently alkyl, aryl, alkenyl or alkynyl;R 2 and R 2'' are independently hydrogen or alkyl;R 4, R 5, R 6 and R 7 each independently are STR2 CH 2 OR 10, CHO, CH 2 NR 11 R 12, hydrogen, halogen,

Convenient preparation of N-substituted indoles by modified Leimgruber-Batcho indole synthesis

A modified reductive alkylation of pre-indole 3, prepared from readily available Leimgruber-Batcho indole synthesis derived intermediates, followed by acidic methanolysis generates 6-carbomethoxy-N-substituted indoles. The three step preparation of pre-indole 3 from substituted 2-nitrotoluene 1 in 66% yield and conversion to a variety of N-substituted indoles is presented.

Palladium-Catalyzed Synthesis of Indoles from 2-Nitrostyrenes

In the presence of palladium salts, oxidation of 2-nitrostyrenes 1 with nitrous acid alkyl esters 2 resulted in the formation of 2-nitrophenylacetaldehyde dialkyl acetals 3.Reductive cyclization of the acetals 3 with iron powder in acetic acid afforded indoles 5 in good yield.