The invention relates to a method of synthesis of phosphoramidites by immobilization of a phosphitylation agent on a resin activated to create a charged resin, then putting in contact with the charged resin with a suitable substrate. Phosphoramidites are synthesized in a few minutes from the application of the starting materials. Thus, the process makes it possible to create specific phosphoramidites on demand when they are needed in other applications. The substrates to be applied are mainly nucleosides, thus making it possible to create nucleoside phosphoramidites for the subsequent synthesis of oligonucleotides.
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Page/Page column 36-38; 48
(2022/01/24)
Binding of aminoglycoside antibiotics with modified A-site 16S rRNA construct containing non-nucleotide linkers
The design and synthesis of synthetically modified cyclic A-site 16S rRNA construct is reported. The binding characteristics of several members of the aminoglycoside antibiotics with this novel class of synthetically modified A-site 16S rRNA constructs we
Tok, Jeffrey B.-H.,Wong, Wilson,Baboolal, Nyla
p. 365 - 370
(2007/10/03)
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