SPACER-9 CEP

Base Information

• Chemical Name: SPACER-9 CEP
• CAS No.: 146668-73-7
• Molecular Formula: C₃₆H₄₉N₂O₇P
• Molecular Weight: 652.768
• Mol file: 146668-73-7.mol

Synonyms:

Chemical Property of SPACER-9 CEP

Chemical Property:

• Boiling Point: 672.1±55.0 °C(Predicted)
• PKA: 3.53±0.70(Predicted)
• PSA: 105.23000
• LogP: 7.33808

Purity/Quality:

>95% by HPLC ^*data from raw suppliers

2-[2-[2-DMT]ethoxy]ethoxy]ethyl CE phosphoramidite ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SPACER-9 CEP

There total 4 articles about SPACER-9 CEP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ diisopropyl-phosphoramidous acid 2-(2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethoxy)-ethyl ester 2-cyano-ethyl ester (146668-73-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; for 0.0833333h;

With dmap; In dichloromethane; toluene; for 0.133333h;

Reference yield:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 2-(2-{[(dimethoxytrityl)oxy]ethoxy}ethoxy)ethanol (146669-11-6) → diisopropyl-phosphoramidous acid 2-(2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethoxy)-ethyl ester 2-cyano-ethyl ester (146668-73-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 2h;

DOI:10.1016/S0960-894X(01)00760-0

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → diisopropyl-phosphoramidous acid 2-(2-{2-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethoxy}-ethoxy)-ethyl ester 2-cyano-ethyl ester (146668-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 4 h / 0 - 20 °C

2: DIPEA / 2 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/S0960-894X(01)00760-0

upstream raw materials:

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

2-(2-{[(dimethoxytrityl)oxy]ethoxy}ethoxy)ethanol

4,4'-dimethoxytrityl chloride

2,2'-[1,2-ethanediylbis(oxy)]bisethanol