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147076-36-6

Laflunimus is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 147076-36-6 Structure

  • Basic information

    1. Product Name: Laflunimus
    2. Synonyms: Laflunimus;LCBOKWGFIPORJD-QBFSEMIESA-N
    3. CAS NO:147076-36-6
    4. Molecular Formula: C15H13F3N2O2
    5. Molecular Weight: 310.274
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 147076-36-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 408.7°Cat760mmHg
    3. Flash Point: 201°C
    4. Appearance: /
    5. Density: 1.441g/cm3
    6. Vapor Pressure: 2.06E-07mmHg at 25°C
    7. Refractive Index: 1.588
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: Laflunimus(CAS DataBase Reference)
    11. NIST Chemistry Reference: Laflunimus(147076-36-6)
    12. EPA Substance Registry System: Laflunimus(147076-36-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 147076-36-6(Hazardous Substances Data)

147076-36-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 147076-36-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,0,7 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 147076-36:
(8*1)+(7*4)+(6*7)+(5*0)+(4*7)+(3*6)+(2*3)+(1*6)=136
136 % 10 = 6
So 147076-36-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H13F3N2O2/c1-8-6-10(4-5-12(8)15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,20,22H,2-3H2,1H3/b14-11-

147076-36-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (Z)-2-cyano-3-cyclopropyl-3-hydroxy-N-[3-methyl-4-(trifluoromethyl)phenyl]prop-2-enamide

1.2 Other means of identification

Product number -
Other names Laflunimus

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:147076-36-6 SDS

147076-36-6Relevant articles and documents

Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl- 3-hydroxy. N-[3'-methyl-4'-(trifluoromethyl)phenyl]propenamide and related compounds

Kuo, Elizabeth A.,Hambleton, Philip T.,Kay, David P.,Evans, Phillip L.,Matharu, Saroop S.,Little, Edward,McDowall, Neil,Jones, C. Beth,Hedgecock, Charles J. R.,Yea, Christopher M.,Chan, A. W. Edith,Hairsine, Peter W.,Ager, Ian R.,Tully, W. Roger,Williamson, Richard A.,Westwood, Robert

, p. 4608 - 4621 (2007/10/03)

The active metabolite (2) of the novel immunosuppressive agent leflunomide (1) has been shown to inhibit the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme catalyzes the fourth step in de novo pyrimidine biosynthesis. A series of analogues of the active metabolite 2 have been synthesized. Their in vivo biological activity determined in rat and mouse delayed type hypersensitivity has been found to correlate well with their in vitro DHODH potency. The most promising compound (3) has shown activity in rat and mouse collagen (II)-induced arthritis models (ED50 = 2 and 31 mg/kg, respectively) and has shown a shorter half-life in man when compared with leflunomide. Clinical studies in rheumatoid arthritis are in progress.

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