147124-38-7

Basic information

• Product Name: Methyl 2-(4-fluoro-2-nitrophenyl)acetate
• Synonyms: Methyl 2-(4-fluoro-2-nitrophenyl)acetate;Ethyl 2-(4-fluoro-2-nitrophenyl)acetate;(4-Fluoro-2-nitro-phenyl)-acetic acid methyl ester
• CAS NO: 147124-38-7
• Molecular Formula: C₉H₈FNO₄
• Molecular Weight: 213.1625232
• Mol File: 147124-38-7.mol

Chemical Properties

• Boiling Point: 288.7°C at 760 mmHg
• Flash Point: 128.4°C
• Appearance: /
• Density: 1.346g/cm³
• Vapor Pressure: 0.0023mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: Methyl 2-(4-fluoro-2-nitrophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(4-fluoro-2-nitrophenyl)acetate(147124-38-7)
• EPA Substance Registry System: Methyl 2-(4-fluoro-2-nitrophenyl)acetate(147124-38-7)

Safety Data

• Hazardous Substances Data: 147124-38-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H8FNO4/c1-15-9(12)4-6-2-3-7(10)5-8(6)11(13)14/h2-3,5H,4H2,1H3

Upstream product

• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 147124-35-4 dimethyl 2-(4-fluoro-2-nitrophenyl)malonate 

Downstream Products

• 908140-01-2 methyl 2-(4-fluoro-2-nitrophenyl)-2-methylpropanoate 
• 56341-39-0 6-fluoro-2-oxindole 

Relevant articles and documents

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

Phenylaminopropanol derivatives and methods of their use

The present invention is directed to phenylaminopropanol derivatives of formulae I, II, and III: [image] or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.

A general oxindole synthesis

A general synthesis of indol-2(3H)-ones (oxindoles), was developed based on the addition of dimethyl malonate to commercially available halonitrobenzenes. The advantage of this route over many other oxindole syntheses was the regiochemical control of the substitution pattern on the aromatic ring.