56341-39-0

Usage

Uses

Used in Organic Synthesis:
6-Fluoro-2-oxindole is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and properties make it a valuable building block for the creation of new molecules with potential applications in different industries.
Used in Drug Discovery:
6-Fluoro-2-oxindole is employed as a starting material or a structural component in the development of new pharmaceuticals. Its enhanced metabolic stability and cell membrane permeability contribute to the discovery of more effective and safer drugs.
Used in Medicinal Chemistry:
6-Fluoro-2-oxindole is used as a research tool in medicinal chemistry to study the structure-activity relationships of potential drug candidates. Its presence in a molecule can provide insights into the compound's interaction with biological targets, leading to the design of more potent and selective therapeutic agents.
Used in Research Applications:
6-Fluoro-2-oxindole is utilized in various research settings to explore its potential applications and properties. Its unique characteristics make it an interesting subject for studies in chemistry, biology, and materials science, among others.

InChI:InChI=1/C8H6FNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-2,4H,3H2,(H,10,11)

Upstream product

• 147124-38-7 methyl (4-fluoro-2-nitrophenyl)acetate 
• 39616-95-0 2-(4-fluoro-2-nitrophenyl)acetic acid 
• 147124-35-4 dimethyl 2-(4-fluoro-2-nitrophenyl)malonate 
• 350-81-2 2-chloro-N-(3-fluorophenyl)acetamide 
• 1209007-72-6 ethyl 2-(4-fluoro-2-nitrophenyl)acetate 
• 399-51-9 6-fluoro-1H-indole 
• 324-03-8 6-fluoroisatin 
• 372-19-0 meta-fluoroaniline 
• 364-74-9 1,4-difluoro-2-nitrobenzene 

Downstream Products

• 70931-61-2 (4-fluoro-2-iodophenyl)acetic acid 
• 80733-63-7 (2-Amino-4-fluoro-phenyl)-acetic acid 
• 114727-45-6 3-(3,4-dichlorobenzylidene)-6-fluoro-oxindole hemihydrate 
• 865079-96-5 (E)-3-benzylidene-6-fluoro-1,3-dihydro-indol-2-one 
• 114727-50-3 {3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-fluoro-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester 
• 1148119-13-4 (E)-6-fluoro-3-(3-hydroxy-4-methoxybenzylidene)indolin-2-one 
• 1148119-16-7 (E)-6-fluoro-3-(3-trifluoromethyl-benzylidene)-1,3-dihydro-indol-2-one 
• 1148119-09-8 (E)-6-fluoro-3-(3-methoxybenzylidene)indolin-2-one 
• 1355679-77-4 4-(dimethylamino)pyridinium 6-fluoro-1,3-bis(phenoxycarbonyl)-1H-indol-2-olate 
• 1355680-02-2 4-(dimethylamino)pyridinium 6-fluoro-3-(phenoxycarbonyl)-1-(piperidin-1-ylcarbonyl)-1H-indol-2-olate 
• 1355679-72-9 phenyl 6-fluoro-2-[(phenoxycarbonyl)oxy]-1H-indole-1-carboxylate 
• 1359105-38-6 (2E,5Z)ethyl 2-(5-benzylidene-2-(2-oxo-6-fluoroindolin-3-ylidene)-4-oxothiazolidin-3-yl)acetate 
• 1378834-16-2 6′-fluoro-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-2′-one 
• 1421506-62-8 (E)-3-(6-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-N-isopropyl-benzene-sulfonamide 

Relevant academic research and scientific papers

A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids

A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and SN1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability.

Synthesis of 2-Oxindoles from Substituted Indoles by Hypervalent-Iodine Oxidation

A practical conversion of indoles into the corresponding 2-oxindoles is achieved efficiently using a hypervalent iodine reagent. This oxidation is amenable to different substituted indoles, and allows the synthesis of a wide range of synthetically valuable substituted 2-oxindoles in up to 90 % yield. Furthermore, Ropinirole, a drug used to alleviate the symptoms of Parkinson's disease, was synthesized in three steps in an overall yield of 44 % using this method.

SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV)

Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, C1-3 alkylene, C2-3 alkenylene or C2-3 alkynylene; R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12- membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, C1-6 haloalkyl, nitro, -CN, -N(R2)2, -OR2, -SR2, -S(=0)R2, or -S(=0)2R2; each R2 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

A Benzisoelenazolone modified pyrrole methyl ester substituted indole ketone compound and use thereof

The invention discloses a benzisoselenazolone-modified pyrrolyl formate-substituted indolone compound and a use thereof. The invention depends on and claims the priority of a Chinese patent application 201110105248.0 submitted on April 26, 2011. Through reference, all contents of the Chinese patent application 201110105248.0 are incorporated into the invention. The benzisoselenazolone-modified pyrrolyl formate-substituted indolone compound is shown in the general formula I. The 2-indolone compound provided by the invention has excellent antitumor activity and can be widely used for preparation of antitumor drugs.

OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

SPIRO-SUBSTITUTED OXINDOLE DERIVATIVES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)- 1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previously we reported

Phenylaminopropanol derivatives and methods of their use

The present invention is directed to phenylaminopropanol derivatives of formulae I, II, and III: [image] or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.

Concise syntheses of the cruciferous phytoalexins brassilexin, sinalexin, wasalexins, and analogues: Expanding the scope of the Vilsmeier formylation

(Chemical Equation Presented) Efficient syntheses of the phytoalexins brassilexin, sinalexin, and analogues are demonstrated through the application of the Vilsmeier formylation to indoline-2-thiones followed by a new aqueous ammonia workup procedure. Similarly, a very concise two-pot synthesis of the phytoalexins wasalexins using sequential formylation-amination of indolin-2-ones is described. Remarkably, this novel aqueous ammonia workup allows the sequential one-pot formylation-amination, expanding substantially the scope of the Vilsmeier formylation of both indoline-2-thiones and indolin-2-ones. The examination of the formylation-amination reaction and optimization of conditions, as well as the syntheses and antifungal activities of several brassilexin analogues, are reported.