Design, Synthesis and Anticancer Evaluation of New 7-O-Alkylation Genistein Derivatives
Genistein is a phytoestrogen compound which possesses multiple biological activities such as anti-cancer, while its application is limited by poor pharmacokinetic properties. Structural modification is an effective approach to get genistein derivatives wi
Synthesis, Characterization, and Antioxidant Activities of Genistein, Biochanin A, and Their Analogues
A series of naturally occurring genistein (3) and biochanin A (4) compounds and their analogues were synthesized from phloroglucinol. The structures of all the synthesized compounds were established by the combined use of 1HNMR, 13CNMR, IR spectral data, and mass spectrometry; their antioxidant activities were investigated. Most of the synthesized compounds show moderate-to-high activity; only two compounds exhibit no significant activity.
Hamza Sherif, Salah,Gebreyohannes, BerihuTekluu
(2018/04/30)
Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo
We report the preparation and antiparasitic activity in vitro and in vivo of a series of isoflavone derivatives related to genistein. These analogues retain the 5,7-dihydroxyisoflavone core of genistein: direct genistein analogues (2-H isoflavones), 2-car
Stachulski, Andrew V.,Berry, Neil G.,Low, Lilian A.C.,Moores, Shelley L.,Row, Eleanor,Warhurst, David C.,Adagu, Ipemida S.,Rossignol, Jean-Fran?ois
p. 1450 - 1454
(2007/10/03)
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