147359-76-0

Basic information

• Product Name: Flibanserin Hydrochloride
• Synonyms: Flibanserin Hydrochloride;Flibanserin HCl
• CAS NO: 147359-76-0
• Molecular Formula: C₂₀H₂₁F₃N₄O*ClH
• Molecular Weight: 426.8630896
• EINECS: 1592732-453-0
• Mol File: 147359-76-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Flibanserin Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Flibanserin Hydrochloride(147359-76-0)
• EPA Substance Registry System: Flibanserin Hydrochloride(147359-76-0)

Safety Data

• Hazardous Substances Data: 147359-76-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Flibanserin Hydrochloride is used as a therapeutic agent for the treatment of hypoactive sexual desire disorder (HSDD) in women. It works by modulating the levels of serotonin in the brain, which is believed to influence sexual desire and arousal. The compound's dual action as a 5-HT1A agonist and 5-HT2A antagonist helps to increase sexual desire and satisfaction in women suffering from HSDD.
In addition to its primary application, Flibanserin Hydrochloride may also have potential uses in other areas of medicine, such as the treatment of sexual dysfunction in men or other conditions related to serotonin regulation. However, further research and clinical trials would be necessary to establish its efficacy and safety in these contexts.

Upstream product

• 167933-07-5 flibanserin 
• 95-54-5 1,2-diamino-benzene 
• 22219-23-4 2-ethoxy-1H-benzo[d]imidazole 
• 52099-72-6 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one 
• 136702-12-0 1-(2-chloro-ethyl)-3-isopropenyl-1,3-dihydro-benzoimidazol-2-one 
• 1971858-36-2 1-(prop-1-en-2-yl)-3-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one 
• 57061-71-9 1-chloro-2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethane 
• 76835-14-8 1-[3-(trifluoromethyl)phenyl]piperazine hydrochloride 

Downstream Products

• 167933-07-5 flibanserin 

Relevant articles and documents

A Facile Route of Synthesis for Making Flibanserin

A novel and efficient route of synthesis for making flibanserin via 2-ethoxy-1H-benzo[d]imidazole (12) was described with excellent yield. This protocol provided a more facile approach to flibanserin.

Preparation method of flibaserin hydrochloride

The invention relates to the technical field of synthesis of medical intermediates, particularly to a preparation method of flibaserin hydrochloride. According to the preparation method, o-phenylenediamine and 3-trifluoromethylphenylpyrazine are used as raw materials; o-phenylenediamine reacts with ethyl acetoacetate to obtain a compound 10-1-G; the 3-trifluoromethylphenylpyrazine compound I is subjected to a two-step substitution reaction to obtain a compound 10-1-B; and the compound 10-1-B and the compound 10-1-G are subjected to a substitution reaction to obtain a final product compound flibaserin hydrochloride. The invention aims to reduce the cost, optimize the process and facilitate industrial production. The method is simple and convenient to operate, reasonable in reaction process,low in production cost, good in product quality, free of environmental pollution and suitable for industrial production, wherein the content of the product is higher than 99.5%.

A preparation method of flibanserin (by machine translation)

The invention discloses a method for preparing of flibanserin, includes the steps of: (1) compound I with dichloroethane reaction to obtain compound II, its without purification, directly with compound III reaction, to obtain the compound IV; (2) compound

NOVEL POLYMORPHS OF FLIBANSERIN HYDROCHLORIDE

The present invention provides novel crystalline anhydrous form II, hemihydrate form III, anhydrous form IV, anhydrous form V, anhydrous form VI, hemihydrate form VII, hemihydrate form VIII, hemihydrate form IX and amorphous form of flibanserin hydrochloride, processes for its preparation and to pharmaceutical compositions containing them.