- Reductive amination and resolution of isochroman-4-one
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The invention discloses a method for preparation of isochroman-4-amine from isochroman-4-one through reductive amination and further dynamic resolution of isochroman-4-amine for preparation of R-isochroman-4-amine. The method provided by the invention has the advantages of simple operation, usage of easily available raw materials, good product yield, high optical purity of the products, etc.
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Paragraph 0005
(2017/08/27)
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- 2-AMINO- AND 2-THIO-SUBSTITUTED 1,3-DIAMINOPROPANES
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Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer’s disease and other diseases characterized by deposition of A beta peptide in a mammal.
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Page/Page column 157
(2008/06/13)
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- METHODS OF TREATMENT OF AMYLOIDOSIS USING BI-CYCLIC ASPARTYL PROTEASE INHIBITORS
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The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
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Page/Page column 260-261
(2010/02/14)
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