- Manganese terpyridine artificial metalloenzymes for benzylic oxygenation and olefin epoxidation
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New catalysts for non-directed hydrocarbon functionalization have great potential in organic synthesis. We hypothesized that incorporating a Mn-terpyridine cofactor into a protein scaffold would lead to artificial metalloenzymes (ArMs) in which the selectivity of the Mn cofactor could be controlled by the protein scaffold. We designed and synthesized a maleimide-substituted Mn-terpyridine cofactor and demonstrated that this cofactor could be incorporated into two different scaffold proteins to generate the desired ArMs. The structure and reactivity of one of these ArMs was explored, and the broad oxygenation capability of the Mn-terpyridine catalyst was maintained, providing a robust platform for optimization of ArMs for selective hydrocarbon functionalization.
- Zhang, Chen,Srivastava, Poonam,Ellis-Guardiola, Ken,Lewis, Jared C.
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supporting information
p. 4245 - 4249
(2014/06/09)
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- A New Aerobic Oxidation System Using Pd-Cu Catalysts in the Presence of CO
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Oxidation of benzylic ethers, tosylamides, and 9,10-dihydroanthracene could be performed efficiently under O2 and CO atmosphere in the presence of PdCl2-CuCl2 catalysts to give the corresponding esters (lactones), amides and anthraquinone, respectively.
- Miyamoto, Masanori,Minami, Yumiko,Ukaji, Yutaka,Kinoshita, Hideki,Inomata, Katsuhiko
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p. 1149 - 1152
(2007/10/02)
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