14770-85-5

Basic information

• Product Name: 2-ThiophenaMine, 5-phenyl-
• Synonyms: 2-ThiophenaMine, 5-phenyl-;5-Phenyl-thiophen-2-ylamine
• CAS NO: 14770-85-5
• Molecular Formula: C₁₀H₉NS
• Molecular Weight: 175.25016
• Mol File: 14770-85-5.mol

Chemical Properties

• Boiling Point: 341.6±30.0 °C(Predicted)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 2.17±0.10(Predicted)
• CAS DataBase Reference: 2-ThiophenaMine, 5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ThiophenaMine, 5-phenyl-(14770-85-5)
• EPA Substance Registry System: 2-ThiophenaMine, 5-phenyl-(14770-85-5)

Safety Data

• Hazardous Substances Data: 14770-85-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Thiophenamine, 5-phenylis used as a key intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties and potential therapeutic effects.
Used in Agrochemical Industry:
2-Thiophenamine, 5-phenylis used as a component in the development of agrochemicals, contributing to the creation of effective products for agricultural applications.
Used in Medicinal Chemistry Research:
2-Thiophenamine, 5-phenylis utilized as a research compound for exploring its anti-inflammatory and antimicrobial properties, with the aim of discovering new treatments and therapies.
Used in Organic Synthesis:
2-Thiophenamine, 5-phenylserves as a building block in the synthesis of a variety of organic compounds, expanding the scope of chemical reactions and products in the organic chemistry field.

Upstream product

• 122-78-1 phenylacetaldehyde 
• 98-80-6 phenylboronic acid 
• 18150-93-1 2-phenyl-5-nitrothiophene 
• 4815-34-3 ethyl 2-amino-5-phenylthiophene-3-carboxylate 
• 883745-73-1 N-(diphenylmethylidene)-5-phenyl-2-thiophenamide 

Downstream Products

• 111298-29-4 1-(5-phenyl-[2]thienylazo)-[2]naphthylamine; hydrochloride 
• 51672-19-6 N,N'-Bis(4,5-dihydro-6-phenyl-3-pyridazinyl)hydrazin 

Relevant articles and documents

Catalyst-Free Site Selective Hydroxyalkylation of 5-Phenylthiophen-2-amine with α-Trifluoromethyl Ketones through Electrophilic Aromatic Substitution

An original and effective approach for achieving trifluoromethyl hydroxyalkylation of 5-phenylthiophen-2-amine using α-trifluoromethyl ketones is described. In the last few years, reaction of Friedel-Crafts had been widely used to realize hydroxyalkylation on heterocycles such as indoles or thiophenes by means of Lewis acid as catalyst. Additionally, amine functions are rarely free when carbonyl reagents are used because of their tendency to form imines. This is the first time that a site-selective electrophilic aromatic substitution on C3 atom of an unprotected 5-phenylthiophen-2amine moiety is reported. The liberty to allow reaction in neutral conditions between free amine is valuable in a synthesis pathway. The reaction proceeds smoothly using an atom-economical metaland catalyst-free methodology in good to excellent yields. A mechanism similar to an electrophilic aromatic substitution has been proposed.

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