On the regiochemistry of the alkylation of terf-butyl N-[6-butyl-1,2-dihydro-2-oxo-3-pyridylmethyl]carbamate: Precursor of a series of potent angiotensin II receptor antagonists
The key intermediate 5 of a large number of potent AT1 selective angiotensin II antagonists e.g. the potent cyclopropylmethyl derivative 1 (EMD 69943) was synthesized by regioselective alkylation of carbamate 3 with the well-known 4′(bromomethy
Koppe, Thomas,Mederski, Werner W. K. R.,Osswald, Mathias,Schwarz, Michael
New 1,2-dihydro-2-oxopyridines of formula I STR1 in which R is the radical STR2 and R1 to R6 and X are as defined herein, and their salts, have antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
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(2008/06/13)
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