On the regiochemistry of the alkylation of terf-butyl N-[6-butyl-1,2-dihydro-2-oxo-3-pyridylmethyl]carbamate: Precursor of a series of potent angiotensin II receptor antagonists

Article abstract of DOI:10.1016/0040-4039(94)02306-V

The key intermediate 5 of a large number of potent AT₁ selective angiotensin II antagonists e.g. the potent cyclopropylmethyl derivative 1 (EMD 69943) was synthesized by regioselective alkylation of carbamate 3 with the well-known 4′(bromomethy