- Dibekacin derivatives and arbekacin derivatives active against resistant bacteria
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As new dibekacin derivatives and new arbekacin derivatives are now provided 2"-amino-2"-deoxydibekacin, 2"-amino-5,2"-dideoxydibekacin, 2"-amino-2"-deoxyarbekacin, 2"-amino-5,2"-dideoxyarbekacin, 2"-amino-5,2"-dideoxy-5-epi-fluoroarbekacin and 2"-amino-5,2"-dideoxy-5-epi-aminoarbekacin which all exhibit high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria, including resistant bacteria such as methicillin-resistant Staphylococcus aureus and which are of low toxicity to mammals and are useful as antibacterial agent for treatment of bacterial infections.
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- Synthesis of 2'-amino-2'-deoxyarbekacin and its analogs having potent activity against methicillin-resistant Staphylococcus aureus
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Based on our studies on the enzymatic modifications of arbekacin by methicillin-resistant Staphylococcus aureus (MRSA), replacement of the 2'-hydroxyl group by an amino group in arbekacin was designed to synthesize derivatives that would be active against
- Kondo,Ikeda,Ikeda,Takeuchi,Usui,Ishii,Kudo,Gomi,Shibahara
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p. 821 - 832
(2007/10/02)
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