148-72-1 Usage
Uses
Used in Ophthalmology:
Pilocarpine nitrate is used as an antiglaucoma agent for reducing intraocular pressure. It functions as a miotic, causing the pupil to constrict, which helps improve the outflow of aqueous humor and lower the pressure within the eye. This application is particularly important for patients with glaucoma, a condition characterized by increased intraocular pressure that can lead to optic nerve damage and vision loss.
Used in Respiratory Medicine:
Pilocarpine nitrate is used as an anticholinergic drug to treat bronchoconstriction, a condition where the airways narrow, making it difficult to breathe. By stimulating the muscarinic receptors in the airways, it helps to relax the smooth muscles and improve airflow, providing relief for patients with respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).
Used in Neurology:
Pilocarpine nitrate has been utilized in the study of neurological conditions and receptor functions. It has been used to induce electrographic and behavioral seizures in animal models, such as Proechimys rats and Wistar rats, to investigate the different patterns of neuronal activation and neurodegeneration. Additionally, it has been employed to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo, providing valuable insights into the underlying mechanisms of various neurological disorders.
Chemical Properties:
Pilocarpine nitrate is a white or almost white, crystalline powder or colorless crystals that are sensitive to light. It is incompatible with alkalies, iodides, silver nitrate, and reagents that precipitate alkaloids.
Brand Name:
One of the brand names for Pilocarpine nitrate is Pilagan, manufactured by Allergan.
Biochem/physiol Actions
Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.
Check Digit Verification of cas no
The CAS Registry Mumber 148-72-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 148-72:
(5*1)+(4*4)+(3*8)+(2*7)+(1*2)=61
61 % 10 = 1
So 148-72-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)
148-72-1Relevant articles and documents
A practical and scaleable total synthesis of the jaborandi alkaloid (+)-pilocarpine
Davies, Stephen G.,Roberts, Paul M.,Stephenson, Peter T.,Storr, Helen R.,Thomson, James E.
experimental part, p. 8283 - 8296 (2009/12/28)
The total synthesis of (+)-pilocarpine (as its nitrate salt) has been achieved in nine steps and 30% overall yield starting from racemic 2-(2′,2′-dimethoxyethyl)propane-1,3-diol, which was desymmetrised via an enzymatic protocol. A high yielding synthesis of a key α-ethylidene lactone precursor has been developed, which involves the palladium-catalysed decarboxylation/carbonylation of a 1,3-dioxan-2-one for formation of the γ-butyrolactone ring. Subsequent hydrogenation of the α-ethylidene lactone introduces the C(3)-stereochemistry to give a 72:28 mixture of (+)-pilocarpine and (+)-isopilocarpine, which are readily separable via recrystallisation of the (+)-pilocarpine nitrate salt.
