- Functionalised nanoparticles, their production and use
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Stable complexes are described, formed by mono- and di-functional compounds bound to nanoparticles composed of various types of transition metal oxides and of metals useful in the production processes of different types of new materials (such as for examp
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- Synthesis, characterization, and in vitro transfection activity of charge-reversal amphiphiles for DNA delivery
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A series of charge-reversal lipids were synthesized that possess varying chain lengths and end functionalities. These lipids were designed to bind and then release DNA based on a change in electrostatic interaction with DNA. Specifically, a cleavable ester linkage is located at the ends of the hydrocarbon chains. The DNA release from the amphiphile was tuned by altering the length and position of the ester linkage in the hydrophobic chains of the lipids through the preparation of five new amphiphiles. The amphiphiles and corresponding lipoplexes were characterized by DSC, TEM, and X-ray, as well as evaluated for DNA binding and DNA transfection. For one specific charge-reversal lipid, stable lipoplexes of approximately 550 nm were formed, and with this amphiphile, effective in vitro DNA transfection activities was observed.
- Zhang, Xiao-Xiang,Prata, Carla A. H.,Berlin, Jason A.,McIntosh, Thomas J.,Barthelemy, Philippe,Grinstaff, Mark W.
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experimental part
p. 690 - 699
(2012/02/16)
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- Chain-Substituted Lipids in Monolayer Films. A Study of Molecular Packing
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A series of highly purified fatty acids and phospholipids, each possessing a chain substituent of varying size (methyl, n-butyl, or phenyl) at varying locations (carbon 4, 8, 12, or 16 of an 18-carbon chain) were synthesized.Pressure-area isotherms, obtained with the aid of a film balance, revealed how these molecules, either individually or admixed, pack in monomolecular films.Two examples will illustrate here the type of information secured by the method. (a) The presence of a methyl at carbon 16 of a single phospholipid chain has a negligible effect on the molecular packing within a "liquid" film.A methyl on carbon 16 of both chains, on the other hand, is highly expansive.Even a single methyl at position 8 perturbs the film packing appreciably, thus indicating less available space near the center of the chain. (b) Deviation from ideality in mixed fatty acid films can be explained by interdigitation that reduces steric repulsion among the substituents.It is also possible to observe by means of film balance techniques the extrusion of 8-butylstearic acid when it contaminates a film composed largely of stearic acid.Approximate SHADOW calculations could, in many cases, provide film areas in reasonable agreement with experiment.
- Menger, F. M.,Wood, M. G.,Richardson, S.,Zhou, Q.,Elrington, A. R.,Sherrod, M. J.
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p. 6797 - 6803
(2007/10/02)
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- SYNTHESIS OF 12-HYDROXYCARBOXYLIC ACIDS FROM 11-CYANOUNDECANOIC ACID
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The synthesis of 12-hydroxy carboxylic acids with the general formula CH3(CH2)n.CHOH.(CH2)10COOH, where n = 1, 3, 5, and 7, was realized from 11-cyanoundecanoic acid and organoaluminium compounds.
- Zakharkin, L. I.,Guseva, V. V.,Churilova, I. M.
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p. 1632 - 1634
(2007/10/02)
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