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2-Hydroxy-7-fluoroquinoline, a fluorine-substituted quinoline derivative, is a heterocyclic compound with the molecular formula C9H6FNO. Characterized by a hydroxyl group and a fluorine atom attached to a quinoline ring, this compound exhibits unique chemical and biological properties. It is recognized for its potential in medicinal chemistry, serving as a key building block for the synthesis of pharmaceuticals and agrochemicals. Additionally, 2-Hydroxy-7-fluoroquinoline is valued for its chemical reactivity and its potential as a ligand in coordination chemistry and catalysis.

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  • 148136-14-5 Structure
  • Basic information

    1. Product Name: 2-HYDROXY-7-FLUOROQUINOLINE
    2. Synonyms: 2-HYDROXY-7-FLUOROQUINOLINE;7-fluoroquinolin-2(1H)-one;7-fluoro-1,2-dihydroquinolin-2-one;EOS-60813
    3. CAS NO:148136-14-5
    4. Molecular Formula: C9H6FNO
    5. Molecular Weight: 163.15
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 148136-14-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-HYDROXY-7-FLUOROQUINOLINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-HYDROXY-7-FLUOROQUINOLINE(148136-14-5)
    11. EPA Substance Registry System: 2-HYDROXY-7-FLUOROQUINOLINE(148136-14-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 148136-14-5(Hazardous Substances Data)

148136-14-5 Usage

Uses

Used in Medicinal Chemistry:
2-Hydroxy-7-fluoroquinoline is used as a building block for the synthesis of pharmaceuticals and agrochemicals, leveraging its unique chemical and biological properties to create novel and effective compounds.
Used in Coordination Chemistry:
2-Hydroxy-7-fluoroquinoline is utilized as a ligand in coordination chemistry, where its chemical reactivity and structural features contribute to the formation of metal complexes with potential applications in various fields.
Used in Catalysis:
As a ligand in catalysis, 2-Hydroxy-7-fluoroquinoline plays a role in enhancing the efficiency and selectivity of catalytic processes, making it a valuable component in the development of new catalytic systems.

Check Digit Verification of cas no

The CAS Registry Mumber 148136-14-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,1,3 and 6 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 148136-14:
(8*1)+(7*4)+(6*8)+(5*1)+(4*3)+(3*6)+(2*1)+(1*4)=125
125 % 10 = 5
So 148136-14-5 is a valid CAS Registry Number.

148136-14-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-fluoro-1H-quinolin-2-one

1.2 Other means of identification

Product number -
Other names 7-FLUOROHYDROXYQUINOLINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148136-14-5 SDS

148136-14-5Downstream Products

148136-14-5Relevant articles and documents

Palladium-catalyzed synthesis of quinolin-2(1: H)-ones: the unexpected reactivity of azodicarboxylate

Peng, Jin-Bao,Chen, Bo,Qi, Xinxin,Ying, Jun,Wu, Xiao-Feng

, p. 1632 - 1635 (2018)

Quinolin-2(1H)-one is a useful structure unit present in a wide range of natural products and pharmaceuticals. A Pd(ii)-catalyzed synthesis of quinolin-2(1H)-ones from quinoline N-oxides was developed with azodicarboxylates which act as both the activating agent and oxidant. The reaction proceeded under mild conditions and no protection against air and moisture was needed.

Solvent-Dependent Cyclization of 2-Alkynylanilines and ClCF2COONa for the Divergent Assembly of N-(Quinolin-2-yl)amides and Quinolin-2(1 H)-ones

Wang, Ya,Zhou, Yao,Ma, Xingxing,Song, Qiuling

, p. 5599 - 5604 (2021/08/01)

Herein, we present an expedient Cu-catalyzed [5 + 1] cyclization of 2-alkynylanilines and ClCF2COONa to divergent construction of N-(quinolin-2-yl)amides and quinolin-2(1H)-ones by regulating the reaction solvents. Notably, nitrile acts as a solvent and performs the Ritter reactions. ClCF2COONa is used as a C1 synthon in this transformation, which also represents the first example for utilization of ClCF2COONa as an efficient desiliconization reagent. The current protocol involves in situ generation of isocyanide, copper-activated alkyne, Ritter reaction and protonation.

Oxidative Aromatization of 3,4-Dihydroquinolin-2(1 H)-ones to Quinolin-2(1 H)-ones Using Transition-Metal-Activated Persulfate Salts

Chen, Weiming,Sun, Changliang,Zhang, Yan,Hu, Tianwen,Zhu, Fuqiang,Jiang, Xiangrui,Abame, Melkamu Alemu,Yang, Feipu,Suo, Jin,Shi, Jing,Shen, Jingshan,Aisa, Haji A.

, p. 8702 - 8709 (2019/07/03)

Inorganic persulfate salts were identified as efficient reagents for the oxidative aromatization of 3,4-dihydroquinolin-2(1H)-ones through the activation of readily available transition metals, such as iron and copper. The feasible protocol conforming to the requirement of green chemistry was utilized in the preparation of the key intermediate (7-(4-chlorobutoxy)quinolin-2(1H)-one 2) of brexpiprazole in 80% isolated yield on a 100 g scale, and different quinolin-2(1H)-one derivatives with various functional groups were demonstrated in 52-89% yields.

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

Igoe, Niall,Bayle, Elliott D.,Tallant, Cynthia,Fedorov, Oleg,Meier, Julia C.,Savitsky, Pavel,Rogers, Catherine,Morias, Yannick,Scholze, Sarah,Boyd, Helen,Cunoosamy, Danen,Andrews, David M.,Cheasty, Anne,Brennan, Paul E.,Müller, Susanne,Knapp, Stefan,Fish, Paul V.

, p. 6998 - 7011 (2017/09/07)

The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Here, we describe NI-57 (16) as new pan-BRPF chemical probe of the bromodomain (BRD) of the BRPFs. Inhibitor 16 preferentially bound the BRD of BRPF1 and BRPF2 over BRPF3, whereas binding to BRD9 was weaker. Compound 16 has excellent selectivity over nonclass IV BRD proteins. Target engagement of BRPF1B and BRPF2 with 16 was demonstrated in nanoBRET and FRAP assays. The binding of 16 to BRPF1B was rationalized through an X-ray cocrystal structure determination, which showed a flipped binding orientation when compared to previous structures. We report studies that show 16 has functional activity in cellular assays by modulation of the phenotype at low micromolar concentrations in both cancer and inflammatory models. Pharmacokinetic data for 16 was generated in mouse with single dose administration showing favorable oral bioavailability.

Tetrahydroquinoline analogues as muscarinic agonists

-

Page/Page column 34, (2017/01/05)

The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.

AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS

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Paragraph 00115, (2014/01/08)

Azetidine and piperidine compounds of formula (I) as defined in the specification, compositions containing them, and processes for preparing such compounds and intermediates thereof. Provided herein also are methods of treating cognitive disorders or dise

NITROGEN HETEROCYCLIC COMPOUNDS USEFUL AS PDE10 INHIBITORS

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Page/Page column 183, (2011/12/02)

Unsaturated nitrogen heterocyclic compounds of formula (I): (I), as defined in the specification, compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, Huntington's Disease, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like.

TRICYCLIC COMPOUNDS AS ANTIBACTERIALS

-

, (2008/12/08)

Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.

DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES

-

, (2008/06/13)

Bicyclic nitrogen containing compounds and their use as antibacterials.

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