148136-14-5

Basic information

• Product Name: 2-HYDROXY-7-FLUOROQUINOLINE
• Synonyms: 2-HYDROXY-7-FLUOROQUINOLINE;7-fluoroquinolin-2(1H)-one;7-fluoro-1,2-dihydroquinolin-2-one;EOS-60813
• CAS NO: 148136-14-5
• Molecular Formula: C9H6FNO
• Molecular Weight: 163.15
• Mol File: 148136-14-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-HYDROXY-7-FLUOROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-7-FLUOROQUINOLINE(148136-14-5)
• EPA Substance Registry System: 2-HYDROXY-7-FLUOROQUINOLINE(148136-14-5)

Safety Data

• Hazardous Substances Data: 148136-14-5(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
2-Hydroxy-7-fluoroquinoline is used as a building block for the synthesis of pharmaceuticals and agrochemicals, leveraging its unique chemical and biological properties to create novel and effective compounds.
Used in Coordination Chemistry:
2-Hydroxy-7-fluoroquinoline is utilized as a ligand in coordination chemistry, where its chemical reactivity and structural features contribute to the formation of metal complexes with potential applications in various fields.
Used in Catalysis:
As a ligand in catalysis, 2-Hydroxy-7-fluoroquinoline plays a role in enhancing the efficiency and selectivity of catalytic processes, making it a valuable component in the development of new catalytic systems.

Upstream product

• 4590-52-7 7-fluoro-3,4-dihydro-1H-quinolin-2-one 
• 497-19-8 sodium carbonate 
• 917341-52-7 (2E)-N-(3-fluorophenyl)-3-phenylprop-2-enamide 
• 944407-13-0 (2E)-N-(3-fluoro-2-methylphenyl)-3-phenyl-2-propenamide 
• 2795-42-8 7-fluoroquinoline 1-oxide 
• 367-29-3 3-fluoro-6-methylaniline 
• 1895-39-2 sodium chlorodifluoroacetate 
• 443-86-7 3-fluoro-2-methylaniline 
• 372-19-0 meta-fluoroaniline 
• 231297-58-8 methyl (2E)-3-(2′-amino-4′-fluorophenyl)prop-2-enoate 
• 1003944-25-9 N-(3-fluorophenyl)-3,3-bis(methyloxy)propanamide 

Relevant articles and documents

Palladium-catalyzed synthesis of quinolin-2(1: H)-ones: the unexpected reactivity of azodicarboxylate

Quinolin-2(1H)-one is a useful structure unit present in a wide range of natural products and pharmaceuticals. A Pd(ii)-catalyzed synthesis of quinolin-2(1H)-ones from quinoline N-oxides was developed with azodicarboxylates which act as both the activating agent and oxidant. The reaction proceeded under mild conditions and no protection against air and moisture was needed.

Solvent-Dependent Cyclization of 2-Alkynylanilines and ClCF2COONa for the Divergent Assembly of N-(Quinolin-2-yl)amides and Quinolin-2(1 H)-ones

Herein, we present an expedient Cu-catalyzed [5 + 1] cyclization of 2-alkynylanilines and ClCF2COONa to divergent construction of N-(quinolin-2-yl)amides and quinolin-2(1H)-ones by regulating the reaction solvents. Notably, nitrile acts as a solvent and performs the Ritter reactions. ClCF2COONa is used as a C1 synthon in this transformation, which also represents the first example for utilization of ClCF2COONa as an efficient desiliconization reagent. The current protocol involves in situ generation of isocyanide, copper-activated alkyne, Ritter reaction and protonation.

Oxidative Aromatization of 3,4-Dihydroquinolin-2(1 H)-ones to Quinolin-2(1 H)-ones Using Transition-Metal-Activated Persulfate Salts

Inorganic persulfate salts were identified as efficient reagents for the oxidative aromatization of 3,4-dihydroquinolin-2(1H)-ones through the activation of readily available transition metals, such as iron and copper. The feasible protocol conforming to the requirement of green chemistry was utilized in the preparation of the key intermediate (7-(4-chlorobutoxy)quinolin-2(1H)-one 2) of brexpiprazole in 80% isolated yield on a 100 g scale, and different quinolin-2(1H)-one derivatives with various functional groups were demonstrated in 52-89% yields.

Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins

The bromodomain and plant homeodomain finger-containing (BRPF) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin. Here, we describe NI-57 (16) as new pan-BRPF chemical probe of the bromodomain (BRD) of the BRPFs. Inhibitor 16 preferentially bound the BRD of BRPF1 and BRPF2 over BRPF3, whereas binding to BRD9 was weaker. Compound 16 has excellent selectivity over nonclass IV BRD proteins. Target engagement of BRPF1B and BRPF2 with 16 was demonstrated in nanoBRET and FRAP assays. The binding of 16 to BRPF1B was rationalized through an X-ray cocrystal structure determination, which showed a flipped binding orientation when compared to previous structures. We report studies that show 16 has functional activity in cellular assays by modulation of the phenotype at low micromolar concentrations in both cancer and inflammatory models. Pharmacokinetic data for 16 was generated in mouse with single dose administration showing favorable oral bioavailability.

Tetrahydroquinoline analogues as muscarinic agonists

The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.

AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS

Azetidine and piperidine compounds of formula (I) as defined in the specification, compositions containing them, and processes for preparing such compounds and intermediates thereof. Provided herein also are methods of treating cognitive disorders or dise

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