14815-19-1

Basic information

• Product Name: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%
• Synonyms: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%;2,2,2-trifluoro-N-(pyridin-3-yl)acetamide
• CAS NO: 14815-19-1
• Molecular Formula: C7H5F3N2O
• Molecular Weight: 190.1226096
• Mol File: 14815-19-1.mol

Chemical Properties

• Melting Point: 122-126℃
• Appearance: /
• CAS DataBase Reference: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%(14815-19-1)
• EPA Substance Registry System: 2,2,2-Trifluoro-N-(3-pyridyl)acetaMide, 96%(14815-19-1)

Safety Data

• Hazardous Substances Data: 14815-19-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,2,2-Trifluoro-N-(3-pyridyl)acetamide, 96% is used as a building block for the synthesis of various organic molecules, leveraging its strong electron-withdrawing properties to facilitate the formation of desired products in chemical reactions.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,2,2-Trifluoro-N-(3-pyridyl)acetamide, 96% is used as a reagent in the preparation of pharmaceutical compounds. Its stability and high reactivity make it a valuable component in the development of new drugs and medicinal agents.

Upstream product

• 462-08-8 pyridin-3-ylamine 
• 407-25-0 trifluoroacetic anhydride 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 668270-12-0 Linagliptin 
• 1673546-62-7 1-[(4-methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-2,2,2-trifluoroacetylaminopiperidin-1-yl)xanthine 
• 77262-40-9 m-<(Trifluoroethyl)amino>pyridine 

Relevant articles and documents

Synthesis of Three pyridines

The synthesis of o-, m, and p-pyridine by diborane/tetrahydrofuran reduction of the corresponding trifluoroacetamide is described.The yields were 52 percent, 83 percent, and 76 percent, respectively.The synthesis, in 53 percent yield, of 2,2,2-trifluoro-N-(4-pyridyl)acetamide is also described.

Adamantylaminopyrimidines and -pyridines are potent inducers of tumor necrosis factor-α

A series of (1-adamantyl)aminopyrimidine and -pyridine derivatives was prepared by adamantyl cation attack on amino heterocycles. The adamantylated compounds, particularly 2-(1-adamantyl)amino-6-methylpyridine, were found to be potent TNF-α inducers in mu

ARYL SULFONAMIDES AS SMALL MOLECULE STAT3 INHIBITORS

The present disclosure provides pharmaceutical compositions comprising aryl sulfonamide Stat3 small molecule inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use for treating cancer.

Compound I and (R)- 3 - amino piperidine hydrochloride II, its preparation method and its application in the synthesis of advantage geleg sandbank

The invention discloses a preparation method of 3-aminopiperidine and its derivative with optical activity and an application of the compound and its derivative in synthesis of a dipeptidyl peptidase-IV inhibitor Linagliptin. According to the preparation

Trifluoroacetylation of amines with trifluoroacetic acid in the presence of trichloroacetonitrile and triphenylphosphine

We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization.

A one-pot procedure for trifluoroacetylation of arylamines using trifluoroacetic acid as a trifluoroacetylating reagent

A convenient procedure for the preparation of aryl trifluoroacetamides from aryl amines is described that employs 2-4 M equiv of trifluoroacetic acid in refluxing xylene as a trifluoroacetylating agent. Addition of an amount of pyridine that is equimolar to the amount of trifluoroacetic acid present in the reaction mixture facilitates the trifluoroacetylation of rather basic arylamines.