148430-28-8Relevant articles and documents
BENZOPYRAN DERIVATIVES
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, (2008/06/13)
Compounds of the Formula: STR1 wherein: R 1 and R 2 are independently hydrogen or lower alkyl, or when taken together with the carbon to which they are attached are cycloalkyl of 3 to 8 carbon atoms; R 3 is fluoro lower alkyl; cyano; or nitro; R 4 is STR2 R 5 and R 6 are independently hydrogen or lower alkyl; and R 7 is--NR 8 R 9 ; wherein:R 8 is hydrogen; lower alkyl; lower alkoxy; hydroxy; or hydroxy lower alkyl; andR 9 is hydrogen; lower alkyl; hydroxy lower alkyl;--SO 2 R 10 ;--CO. sub.2 R 10 ;--C(O)NR 11 R 12 ;--C(S)NR 11 R 12 ; or--C(O)R 12 ; whereinR 10 is lower alkyl;R 11 is hydrogen or lower alkyl; andR. sup.12 is hydrogen, lower alkyl, or fluoro lower alkyl; with the proviso that R 8 and R 9 cannot both be hydrogen; and the pharmaceutically acceptable salts thereof. The compounds and salts exhibit useful pharmacological properties, including potassium channel activating properties and 5-lipoxygenase inhibiting properties, and in particular are useful as smooth muscle relaxants and bronchodilators.
